Abstract:
:Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were farnesylated in vitro by mammalian farnesyl:protein transferase, and epitope-tagged PTP(CAAX2) was prenylated in epithelial cells. Overexpression of PTP(CAAXI) and PTP(CAAX2) in epithelial cells caused a transformed phenotype in culture and tumor growth in nude mice. Thus, PTP(CAAXI) and PTP(CAAX2) represent a novel class of isoprenylated, oncogenic protein tyrosine phosphatases.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Cates CA,Michael RL,Stayrook KR,Harvey KA,Burke YD,Randall SK,Crowell PL,Crowell DNdoi
10.1016/s0304-3835(96)04459-xsubject
Has Abstractpub_date
1996-12-20 00:00:00pages
49-55issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(96)04459-Xjournal_volume
110pub_type
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