Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases.

Abstract:

:Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were farnesylated in vitro by mammalian farnesyl:protein transferase, and epitope-tagged PTP(CAAX2) was prenylated in epithelial cells. Overexpression of PTP(CAAXI) and PTP(CAAX2) in epithelial cells caused a transformed phenotype in culture and tumor growth in nude mice. Thus, PTP(CAAXI) and PTP(CAAX2) represent a novel class of isoprenylated, oncogenic protein tyrosine phosphatases.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Cates CA,Michael RL,Stayrook KR,Harvey KA,Burke YD,Randall SK,Crowell PL,Crowell DN

doi

10.1016/s0304-3835(96)04459-x

subject

Has Abstract

pub_date

1996-12-20 00:00:00

pages

49-55

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(96)04459-X

journal_volume

110

pub_type

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