Absence of hSNF5/INI1 mutation in human lung cancer.

abstract：:The synthetic compound 1,2-dimethylhydrazine is employed in carcinogenesis studies because of its reliable and specific ability to produce colon tumors in rodents. Male Fischer rats were treated at 7 weeks of age with a single oral dose of 1,2-dimethylhydrazine (35 mg/kg) and examined at autopsy 1.5 years later when t...

journal_title：Cancer letters

authors： Southern JT,Schiller CM

更新日期：1981-10-01 00:00:00

abstract：:Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of trans...

journal_title：Cancer letters

authors： Shanmugam MK,Dai X,Kumar AP,Tan BK,Sethi G,Bishayee A

更新日期：2014-05-01 00:00:00

abstract：:Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells; they mediate the activation of caspase-1, leading to cellular pyroptosis. So far, a variety of studies on inflammasomes have emerged, and the best-studied is the NLRP3 inflammasome that is involved in many inflammatory ...

journal_title：Cancer letters

authors： Jiang D,Chen S,Sun R,Zhang X,Wang D

更新日期：2018-04-10 00:00:00

abstract：:Chemically-induced mutagenesis and carcinogenesis is modulated by various plant products, some of which are present in the human diet. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent carcinogen in tobacco and tobacco smoke, is activated by microsomal enzymes. In this study, we investigated the effects o...

journal_title：Cancer letters

authors： Miller CH,Zhang Z,Hamilton SM,Teel RW

更新日期：1993-11-30 00:00:00

abstract：:Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin α5β1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Here we show that inhibition of α5 integrin subun...

journal_title：Cancer letters

authors： Janouskova H,Ray AM,Noulet F,Lelong-Rebel I,Choulier L,Schaffner F,Lehmann M,Martin S,Teisinger J,Dontenwill M

更新日期：2013-08-19 00:00:00

abstract：:N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...

journal_title：Cancer letters

authors： Runge RG,Pour P

更新日期：1980-10-01 00:00:00

abstract：:Vitamin C has been suggested and disputed as an anti-cancer agent. Previous in vitro studies using either primary cell cultures from cancer patients or tumor cell lines have suggested that tumor cells with different lineages may have different sensitivities to ascorbic acid. In this study we report characterization of...

journal_title：Cancer letters

authors： Kao TL,Meyer WJ 3rd,Post JF

更新日期：1993-06-15 00:00:00

abstract：:Liposome encapsulation of anticancer agents results in reduced side effects of the entrapped drug and improved therapeutic efficacy. The external surface of the lipidic envelope can be coupled with antibodies directed against tumor-associated antigens. The resulting immunoliposomes allow to increase the therapeutic in...

journal_title：Cancer letters

authors： Brignole C,Marimpietri D,Pagnan G,Di Paolo D,Zancolli M,Pistoia V,Ponzoni M,Pastorino F

更新日期：2005-10-18 00:00:00

abstract：:The aim of the study was to prove whether or not an association exists between the heat shock protein 70 (hsp70) and drug resistance. Tumor samples of 90 patients with previously untreated non-small lung carcinomas were investigated immunohistochemically for expression of resistance related proteins. Additionally, res...

journal_title：Cancer letters

authors： Volm M,Koomägi R,Mattern J,Stammler G

更新日期：1995-08-16 00:00:00

abstract：:This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical castration increases LIMK2 expression in mouse prostates due to ...

journal_title：Cancer letters

authors： Nikhil K,Chang L,Viccaro K,Jacobsen M,McGuire C,Satapathy SR,Tandiary M,Broman MM,Cresswell G,He YJ,Sandusky GE,Ratliff TL,Chowdhury D,Shah K

更新日期：2019-04-28 00:00:00

abstract：:Women who have breast cysts with intracystic Na+/K+ < 3 may have a higher risk of developing breast cancer than women who have breast cysts with intracystic Na+/K+ > 3. In this study wide-ranging intracystic concentrations of cathepsin D and pS2 (oestrogen inducible proteins/polypeptides) as well as oestradiol were fo...

journal_title：Cancer letters

authors： Lai LC,Cornell C,Lennard TW

更新日期：1993-04-15 00:00:00

abstract：:Fas/APO-1/CD95, a member of the tumor necrosis factor (TNF) receptor superfamily, is a potential anti-cancer factor as it can induce apoptosis in tumor cells. However, despite the fact that many cancer cells express Fas on the membrane, some tumors such as prostate cancer display resistance to Fas-induced apoptosis. I...

journal_title：Cancer letters

authors： Park IJ,Kim MJ,Park OJ,Park MG,Choe W,Kang I,Kim SS,Ha J

更新日期：2010-12-01 00:00:00

abstract：:Exosomes are structurally and functionally pleiotropic nano-sized (~30-150 nm in diameter) extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all cells and play a significant role in intercellular communication and bio-waste disposal. To a great extent, exosomes represent biologi...

journal_title：Cancer letters

authors： Kumar A,Deep G

更新日期：2020-09-28 00:00:00

abstract：:Tumor promoters such as phorbol esters, teleocidin and okadaic acid increase the numbers of multilayered, transformed foci produced by BPV DNA-transfected C3H/10T1/2 cells. We questioned whether arsenic and chromium, which are known human carcinogens also enhance transformation of BPV DNA-transfected C3H/10T1/2 cells....

journal_title：Cancer letters

authors： Kowalski LA,Tsang SS,Davison AJ

更新日期：1996-05-15 00:00:00

abstract：:Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years, however, acquired resistance has emerged as a daunting challenge to anticancer treatments including chemotherapy, radiation and targeted therapy, which abolishes the efficacy of otherwise successful regimens. Cancer cells ...

journal_title：Cancer letters

authors： Sun Y

更新日期：2016-09-28 00:00:00

abstract：:Protein kinase C epsilon (PKCε), a member of the novel PKC family, is known to be a transforming oncogene and tumor biomarker for many human solid cancers including renal cell carcinoma (RCC). We isolated side population (SP) cells from the RCC 769P cell line, and proved that those cells possess cancer stem cell (CSC)...

journal_title：Cancer letters

authors： Huang B,Fu SJ,Fan WZ,Wang ZH,Chen ZB,Guo SJ,Chen JX,Qiu SP

更新日期：2016-06-28 00:00:00

abstract：:BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation...

journal_title：Cancer letters

authors： Fabbro M,Henderson BR

更新日期：2008-05-18 00:00:00

abstract：:In the present study a methodological approach is taken which quantitates aberrant dysplastic crypts in the unsectioned murine colon. C57BL/6J or CF1 female mice (7-8 weeks old) were injected (i.p.) with azoxymethane (5 mg/kg body wt./week) for 4 weeks. Their colons were excised, cut open on the median axis and fixed ...

journal_title：Cancer letters

authors： Bird RP

更新日期：1987-10-30 00:00:00

abstract：:N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. The...

journal_title：Cancer letters

authors： Chung JG,Kuo HM,Lin TH,Ho CC,Lee JH,Lai JM,Levy GN,Weber WW

更新日期：1996-08-23 00:00:00

abstract：:Because of the abnormal vasculature, most growing solid tumors contain regions that experience either acute or chronic hypoxia. However, tumor cells can maintain a high glycolytic rate even when there is enough oxygen supply. Hypoxia-inducible factors (HIFs) play crucial role in the response of tumor cells to this dis...

journal_title：Cancer letters

authors： Zeng W,Liu P,Pan W,Singh SR,Wei Y

更新日期：2015-01-28 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that cir...

journal_title：Cancer letters

authors： Zhou R,Wu Y,Wang W,Su W,Liu Y,Wang Y,Fan C,Li X,Li G,Li Y,Xiong W,Zeng Z

更新日期：2018-07-01 00:00:00

abstract：:Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A ampli...

journal_title：Cancer letters

authors： Bodvarsdottir SK,Hilmarsdottir H,Birgisdottir V,Steinarsdottir M,Jonasson JG,Eyfjord JE

更新日期：2007-04-08 00:00:00

abstract：:Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACT...

journal_title：Cancer letters

authors： Li LB,Louie MC,Chen HW,Zou JX

更新日期：2008-03-08 00:00:00

abstract：:Neoxanthin and fucoxanthin, which have the characteristic structure of 5,6-monoepoxide and an allenic bond, were previously found to reduce the viability of human prostate cancer cells most intensively among 15 dietary carotenoids tested. In the present study, the induction of apoptosis in PC-3 cells by these two caro...

journal_title：Cancer letters

authors： Kotake-Nara E,Asai A,Nagao A

更新日期：2005-03-18 00:00:00

abstract：:We examined the effect of alcohol consumption, cigarette smoking and flushing response on esophageal squamous cell carcinoma (ESCC) in a large-scale population-based cohort study. 44,970 middle-aged and older Japanese men were followed. A total of 215 cases of ESCC were newly diagnosed. Alcohol consumption and cigaret...

journal_title：Cancer letters

authors： Ishiguro S,Sasazuki S,Inoue M,Kurahashi N,Iwasaki M,Tsugane S,JPHC Study Group.

更新日期：2009-03-18 00:00:00

abstract：:Formation of DNA-adducts by 3-BHA or its metabolites, i.e., tert-butyl-1,4-benzoquinone (TBQ) and 5-methoxy-3-tert-butyl-1,2-benzoquinone (3-TBOQ), as well as DNA-adduct formation by 4-nitroquinoline-N-oxide (4NQO), in rat forestomach were examined by an enzymatic 32P-postlabeling assay. Four DNA-adducts were clearly ...

journal_title：Cancer letters

authors： Saito K,Nakagawa S,Yoshitake A,Miyamoto J,Hirose M,Ito N

更新日期：1989-12-01 00:00:00

abstract：:It is now well established that increased programmed death-1-ligand 1 (PD-L1) surface expression in cancer cells and the resultant T cell suppression contribute to cancer cell immune evasion. Blockade of PD-L1 function has been shown to stimulate anti-cancer immunity. Therefore, compounds that can down-regulate PD-L1 ...

journal_title：Cancer letters

authors： Liang M,Yang H,Fu J

更新日期：2009-04-08 00:00:00

abstract：:This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HR...

journal_title：Cancer letters

authors： Martin LM,Marples B,Lynch TH,Hollywood D,Marignol L

更新日期：2014-07-10 00:00:00

abstract：:Human cytolytic fusion proteins (hCFPs) offer a promising immunotherapeutic approach for the treatment of solid tumors, avoiding the immunogenicity and undesirable side-effects caused by immunotoxins derived from plants or bacteria. The well-characterized human serine protease granzyme B has already been used as a the...

journal_title：Cancer letters

authors： Niesen J,Hehmann-Titt G,Woitok M,Fendel R,Barth S,Fischer R,Stein C

更新日期：2016-05-01 00:00:00

abstract：:It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one ...

journal_title：Cancer letters

authors： Rodvold JJ,Mahadevan NR,Zanetti M

更新日期：2016-09-28 00:00:00