Abstract:
:It is now well established that increased programmed death-1-ligand 1 (PD-L1) surface expression in cancer cells and the resultant T cell suppression contribute to cancer cell immune evasion. Blockade of PD-L1 function has been shown to stimulate anti-cancer immunity. Therefore, compounds that can down-regulate PD-L1 surface expression in cancer cells may serve as novel immune modulators to promote cancer cell-reactive immune responses. In the present study, we examined the effects of nimesulide, a selective COX-2 inhibitor, on PD-L1 surface expression in breast cancer cells by flow cytometry. We demonstrated that nimesulide was able to inhibit IFN-gamma-induced PD-L1 surface expression in breast cancer cells. However, our data indicate that the inhibitory effects of nimesulide appear to be independent of COX-2/PGE2 signaling. Since nimesulide also exhibits anti-tumor activities by inducing cancer cell apoptosis and inhibiting cancer cell proliferation, our findings suggest that nimesulide may represent a new class of chemotherapeutic agents that possess dual functions to inhibit cancer cell growth and promote cancer cell immune responses.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Liang M,Yang H,Fu Jdoi
10.1016/j.canlet.2008.10.028subject
Has Abstractpub_date
2009-04-08 00:00:00pages
47-52issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00854-9journal_volume
276pub_type
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