Potent tumorigenicity of 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene in the neonatal B6C3F (1) male mouse.


:The tumorigenicity of 7-chlorobenz[a]anthracene (7-Cl-BA, and environmental contaminant, and 7 bromobenz[a]anthracene (7-Br-BA) was determines in the male B6C3F(1) newborn mouse. Mice receiving 7-Cl-BA and 7-Br-BA by i.p. injections at a dose of 1600 nmol per mouse on 1, 8, and 15 days after birth developed 92 and 96% hepatocellular adenomas, and 100 and 83% hepatocellular carcinoma, respectively. Metabolism by liver microsomes of 15-day-old mice each produced the corresponding trans-3,4-dihydrodiol. Analysis by (32)P-postlabeling/HPLC indicated the presence of DNA adducts derived from 7-Cl-BA trans-3,4-dihydrodiol and 7-Br-BA trans-3,4-dihydrodiol. Our results indicate that both 7-Cl-BA and 7-Br-BA are potent carcinogens and that bay-region diol epoxides are the ultimate metabolites that lead to DNA adduct formation and tumor initiation.


Cancer Lett


Cancer letters


Fu PP,Von Tungeln LS,Zhan DJ,Bucci T




Has Abstract


1996-03-19 00:00:00














  • BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters.

    abstract::BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Fabbro M,Henderson BR

    更新日期:2008-05-18 00:00:00

  • MCF-7 breast cancer cell line grown in agarose culture for study of COX-2 inhibitors in three-dimensional growth system.

    abstract::Herein we report a method for studying slow acting pharmaceutical COX-2 inhibitors in the MCF-7 breast cancer cell line where cells are grown in a three-dimensional format within an agarose matrix. The cancer cells are suspended in agarose and plated in a cell culture dish, where they will form small multicellular 'tu...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kinder DH,Aulthouse AL

    更新日期:2004-03-08 00:00:00

  • Mutagenicity of the two main components of commercially available carcinogenic aristolochic acid in Salmonella typhimurium.

    abstract::One of the 2 main components of the commercially available carcinogenic aristolochic acid (AA) was isolated, the other was enriched. Three different aristolochic acid samples (AAI 99% pure; AAI 65% + AAII 35%; AAI 32% + AAII 68%) were assayed for mutagenic activity in Salmonella typhimurium TA1537, TA100 and TA100 NR ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Schmeiser HH,Pool BL,Wiessler M

    更新日期:1984-05-01 00:00:00

  • Associated nutritional risk of breast and colon cancers: a population-based case-control study in Montreal, Canada.

    abstract::To investigate whether particular patterns of food consumption are related to the occurrence of breast and colon cancer, two simultaneous case-control studies of French-Canadians with 616 cases (414 breast cancer, 202 colon cancer) and 429 population-based controls were carried out. Food consumption data were obtained...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nkondjock A,Ghadirian P

    更新日期:2005-06-01 00:00:00

  • Application of the polymerase chain reaction (PCR) to quantify micro-metastasis in an experimental animal.

    abstract::In vitro cultured r/mHM-SFME-1 cells were injected into the hind foot pads of Balb/c mice. Metastasis was detected in the lungs of tumor-bearing mice by means of both PCR and histological methods. Primers for the PCR were set to amplify a 128 bp exon-1 sequence of the human c-Ha-ras1 gene which had been introduced int...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Matano S,Ryoyama K,Nakamura S,Okada G,Nomura T

    更新日期:1995-05-04 00:00:00

  • Point mutations at codon 12 of C-K-ras in human endometrial carcinomas.

    abstract::Samples of human endometrial carcinomas of ranging degree of histological differentiation, and normal endometrial tissues were screened for the presence of single site DNA mutations at codon 12 of the C-K-ras gene using oligonucleotide hybridisation of DNA amplified by the polymerase chain reaction (PCR). Two instance...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lester DR,Cauchi MN

    更新日期:1990-05-15 00:00:00

  • Effect of bile acids on formation of azoxymethane-induced aberrant crypt foci in colostomized F344 rat colon.

    abstract::The effect of bile acids on the formation of azoxymethane induced aberrant crypt foci (ACF) was investigated using the fecal stream-excluded colons of colostomized F344 rats. The excluded colon was irrigated with saline or bile acids (1 mg/0.5 ml per day, 5 days/week) for 4 weeks. The mean numbers of ACF per colon in ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lin CX,Umemoto A,Seraj MJ,Mimura S,Monden Y

    更新日期:2001-08-28 00:00:00

  • Translocations involving chromosome 1 in hormone-independent GR mouse mammary tumors.

    abstract::Large marker chromosomes were found in 2 hormone-independent (HI) GR mouse mammary tumors, i.e. a tumor (TSl 75) that was already HI at the first transplantation, and a tumor (TSl 66) that became HI at the 19th passage. These marker chromosomes appear to be translocations to distal and proximal ends of chromosome 1, r...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Sluyser M,Evers P,Hilgers J

    更新日期:1985-06-01 00:00:00

  • Enhanced thermal response of a rat sarcoma by Corynebacterium parvum.

    abstract::Corynebacterium parvum was investigated in the response of rat Mc7 sarcoma to local waterbath hyperthermia. Heat treatment of 1-1.5 cm3 foot tumors at 43 degrees C for 2 h resulted in complete regression of 71% of the tumors. The Mc7 cure was reduced to 31% when the tumors were heated at 43 degrees C for 1.5 h. C. par...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Shah SA

    更新日期:1985-03-01 00:00:00

  • Acute inhibition of DNA synthesis in hamster buccal pouch epithelium exposed to indirect acting carcinogens.

    abstract::Inhibition of DNA synthesis was observed and quantitated in hamster buccal pouch epithelium exposed in vivo and in vitro to indirect acting carcinogens. Topical application of a 0.5% solution of the potent hamster buccal pouch carcinogen 7,12-dimethylbenz[a]-anthracene (DMBA) acutely inhibited epithelial DNA synthesis...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nagabhushan M,Ng YK,Elias R,Polverini PJ,Solt DB

    更新日期:1990-09-01 00:00:00

  • Volatilization of mutagens from beef during cooking.

    abstract::The process of cooking beef substances which are mutagenic in the Ames Salmonella/microsome bioassay [1,2]. In this study, the formation and disposition of basic mutagens produced by cooking beef at different temperatures were examined. Mutagenic activity increased exponentially with cooking temperature between 137 de...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Rappaport SM,McCartney MC,Wei ET

    更新日期:1979-12-01 00:00:00

  • Regulation of death promoter Bak expression by cell density and 17 beta-estradiol in MCF-7 cells.

    abstract::In the current study we examined the regulation of Bak, a death promoter of an apoptotic pathway, in the human breast cancer cell line MCF-7. We observed a time-dependent increase in both Bak mRNA and protein levels which appeared to correlate well with the increase in cell density. We also found that treatment of cel...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Leung LK,Do L,Wang TT

    更新日期:1998-02-13 00:00:00

  • Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines.

    abstract::FOY-305 is a synthetic serine protease inhibitor and ONO-3403 and FO-349 are its derivatives. The effects of these compounds on the proliferation of 13 human neuroblastoma cell lines were investigated in vitro by MTT colorimetric assay. The half maximum inhibition concentrations of ONO-3403 varied between 22 and 90 mi...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hiwasa T,Kondo K,Nakagawara A,Ohkoshi M

    更新日期:1998-04-24 00:00:00

  • Migration and metalloproteinases determine the invasive potential of mouse melanoma cells, but not melanin and telomerase.

    abstract::The biological characteristic cell locomotion and invasion, melanin content, metalloproteinases and telomerase activity were studied in a parental mouse melanoma cell line B16 and two descendents B16BL6 and B16F10. The invasive potential of melanoma cells was assayed in a transwell cell culture chamber. Melanin conten...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Zhao W,Liu H,Xu S,Entschladen F,Niggemann B,Zänker KS,Han R

    更新日期:2001-01-01 00:00:00

  • Potential of endogenous formation of volatile nitrosamines from Nigerian vegetables and spices.

    abstract::Nitrosatability of dried Nigerian vegetables and spices was investigated under simulated gastric conditions. N-Nitroso-dimethylamine (NDMA) was the only volatile nitrosamine found above the preformed level except in ugwu where N-nitroso-piperidine (2.3 ppb) was also detected. The lowest NDMA value of 0.4 ppb was found...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Atawodi SE,Maduagwu EN,Preussmann R,Spiegelhalder B

    更新日期:1991-05-24 00:00:00

  • Prognostic significance of tumor angiogenesis in primary fallopian tube cancer.

    abstract::Tumor angiogenesis has been found to be prognostically significant in many types of malignant tumors. We assessed tumor vascularity in 43 cases of histologically proven primary fallopian tube cancer, FIGO stage I-IV, using the highly specific endothelial cell marker CD34. Microvessel count was determined by counting C...

    journal_title:Cancer letters

    pub_type: 杂志文章,多中心研究


    authors: Bancher-Todesca D,Rosen A,Graf A,Wasicky R,Hohlagschwandtner M,Rebhandl W,Heinze G,Breitenecker G,Gitsch G,Obermair A

    更新日期:1999-07-01 00:00:00

  • Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents.

    abstract::Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA-DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indicated that AA signif...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Cheng CL,Chen KJ,Shih PH,Lu LY,Hung CF,Lin WC,Yesong Gu J

    更新日期:2006-02-08 00:00:00

  • Effect of probenecid and N'-methylnicotinamide on renal handling of cis-dichlorodiammineplatinum-II in rats.

    abstract::The renal handling of cisplatin was investigated in Sprague-Dawley rats in the presence and absence of probenecid and N'-methylnicotinamide. The renal clearance of free cisplatin was not significantly different from the glomerular filtration rate. N'-Methylnicotinamide, an organic cation, did not affect cisplatin clea...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Osman NM,Litterst CL

    更新日期:1983-05-01 00:00:00

  • Dietary regulation of mammary tumorigenesis in RIII/Sa mice: investigation of a possible mechanism.

    abstract::The effects of caloric restriction on the incidence of mammary tumor development, the levels of the expression of mouse mammary tumor virus (MMTV)- and prolactin-RNA, as well as the levels of serum prolactin, were investigated in virgin RIII/Sa mice, a strain known to display a high incidence of spontaneous mammary tu...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li HW,Zhao W,Sarkar NH

    更新日期:1994-05-16 00:00:00

  • Fluorescence photography as a diagnostic method for oral cancer.

    abstract::This study was carried out to evaluate the diagnostic utility of autofluorescence photography for oral mucosal lesions. The materials consisted of 15 chemically-induced lesions containing carcinomas in 15 hamsters, and 32 oral lesions in 30 patients. In the animal models, orange fluorescence was detected in all squamo...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Onizawa K,Saginoya H,Furuya Y,Yoshida H

    更新日期:1996-11-12 00:00:00

  • Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma.

    abstract::Tumor acidity is now considered an important determinant of drug-resistance and tumor progression, and anti-acidic approaches, such as Proton Pump inhibitors (PPIs), have demonstrated promising antitumor and chemo-sensitizing efficacy. The main purpose of the present study was to evaluate the possible PPI-induced sens...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Azzarito T,Venturi G,Cesolini A,Fais S

    更新日期:2015-01-28 00:00:00

  • Accelerating action of tea on mouse skin carcinogenesis.

    abstract::The effect of different tannin-containing aqueous solutions on the carcinogenic action of benzo(a)pyrene (BP) on the mouse skin was investigated. It was found that the appearance of tumours was accelerated in mice treated with either tea or an oak extract after a single application of BP. The time of appearance of tum...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Bogovski P,Day N

    更新日期:1977-07-01 00:00:00

  • Frequent allelic loss on chromosomes 4q and 16q associated with human hepatocellular carcinoma in Taiwan.

    abstract::To define the critical region of liver-specific tumor suppressor genes in human hepatocellular carcinoma (HCC), we analyzed 30 cases of hepatocellular carcinoma using nine 4q and six 16q microsatellite polymorphic DNA markers. We observed one major common deleted region which was flanked by D4S175-D4S1625 and there ma...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Chou YH,Chung KC,Jeng LB,Chen TC,Liaw YF

    更新日期:1998-01-16 00:00:00

  • Dose-response study of MeIQx carcinogenicity in F344 male rats.

    abstract::The dose-dependence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity when given in the diet continuously throughout the experiment (56 weeks) at doses of 100, 200 and 400 ppm, was examined in F344 male rats. Tumors developed dose-dependently in the liver, Zymbal glands and skin in the experimen...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kushida H,Wakabayashi K,Sato H,Katami M,Kurosaka R,Nagao M

    更新日期:1994-08-15 00:00:00

  • alpha-Toxin of Staphylococcus aureus overcomes acquired cisplatin-resistance in malignant mesothelioma cells.

    abstract::alpha-Toxin (alpha-hemolysin) of Staphylococcus aureus is a pore-forming bacterial toxin which after caveolin-1-dependent assembly induces apoptosis in eukaryotic cells. We investigated if a sub-toxic concentration of staphylococcal alpha-toxin could enhance cisplatin-induced apoptosis and overcome acquired cisplatin-...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Johansson D,Johansson A,Behnam-Motlagh P

    更新日期:2008-06-28 00:00:00

  • Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells.

    abstract::Substantial evidence from epidemiological studies supports the inverse association between the intake of fruits, vegetables and other plant products and cancer incidence. Cancer-preventive constituents of fruits and vegetables may inhibit carcinogen activation, enhance carcinogen detoxification, prevent carcinogens fr...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tatman D,Mo H

    更新日期:2002-01-25 00:00:00

  • Lipids status in human breast cyst fluids.

    abstract::Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Mannello F,Bocchiotti GD,Morano FP,Fratepietro LM,Gazzanelli G

    更新日期:1996-01-02 00:00:00

  • Anti-tumor-promoting effects of phenylpropanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.

    abstract::In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradeca...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ito C,Itoigawa M,Furukawa H,Ichiishi E,Mukainaka T,Okuda M,Ogata M,Tokuda H,Nishino H

    更新日期:1999-07-19 00:00:00

  • Tumor microenvironment and cancer therapy resistance.

    abstract::Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years, however, acquired resistance has emerged as a daunting challenge to anticancer treatments including chemotherapy, radiation and targeted therapy, which abolishes the efficacy of otherwise successful regimens. Cancer cells ...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Sun Y

    更新日期:2016-09-28 00:00:00

  • MiRNA-29b suppresses tumor growth through simultaneously inhibiting angiogenesis and tumorigenesis by targeting Akt3.

    abstract::The traditional anti-angiogenic cancer therapy could trigger hypoxia induced factor (HIF) response, leading to "reactive resistance" to chemotherapy. Simultaneously inhibiting both angiogenesis and tumorigenesis would be ideal to overcome this limitation. MicroRNAs (miRNAs) are increasingly explored as new agents for ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li Y,Cai B,Shen L,Dong Y,Lu Q,Sun S,Liu S,Ma S,Ma PX,Chen J

    更新日期:2017-07-01 00:00:00