Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx.

abstract：:This review centers on recent findings with respect to modulating cancer multidrug resistance (MDR) with the well-known antidepressant fluoxetine (prozac). The MDR phenomena and mechanisms are discussed, including the roles of ABC transporters as MDR-pumps and the potential involvement of cancer stem cells. The three ...

journal_title：Cancer letters

authors： Peer D,Margalit R

更新日期：2006-06-18 00:00:00

abstract：:We aimed to clarify the clinical significance of des-gamma-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC,...

journal_title：Cancer letters

authors： Shimada M,Yamashita Y,Hamatsu T,Hasegawa H,Utsunomiya T,Aishima S,Sugimachi K

更新日期：2000-10-16 00:00:00

abstract：:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...

journal_title：Cancer letters

authors： Kleinjans JC,Pluijmen MH,Hageman GJ,Verhagen H

更新日期：1989-01-01 00:00:00

abstract：:CD271, known as a neurotrophin receptor, is expressed in various cancers such as hypopharyngeal cancer (HPC) and melanoma. We recently reported that CD271 is a cancer-stem-cell biomarker of HPC, and that its expression is essential for cancer-cell proliferation and is correlated with a poor prognosis in this disease. ...

journal_title：Cancer letters

authors： Morita S,Mochizuki M,Wada K,Shibuya R,Nakamura M,Yamaguchi K,Yamazaki T,Imai T,Asada Y,Matsuura K,Sugamura K,Katori Y,Satoh K,Tamai K

更新日期：2019-10-01 00:00:00

abstract：:Previous studies have demonstrated that fibroblast growth factor 8b (FGF8b) is up-regulated in a large proportion of prostate cancer patients and that it plays a key role in prostate carcinogenesis. In this study, we designed and synthesized a gN helix domain derived short peptide (termed 8b-13) based on the analysis ...

journal_title：Cancer letters

authors： Li T,Luo W,He D,Wang R,Huang Y,Zeng X,Wang W,Chen X,Gao S,Yu Y,Li X,Wu X

更新日期：2013-10-10 00:00:00

abstract：:We evaluated the changes in CTC count and CTC-associated miRNAs during the course of chemotherapy in patients with metastatic colorectal cancer. Blood samples were collected from 9 metastatic colorectal cancer patients prior to chemotherapy and at every other chemotherapy session during the course of treatment. CTCs w...

journal_title：Cancer letters

authors： Tan K,Leong SM,Kee Z,Caramat PV,Teo J,Blanco MVM,Koay ESC,Cheong WK,Soh TI,Yong WP,Pang A

更新日期：2018-06-01 00:00:00

abstract：:Application of functional imaging to radiotherapy (RT) is a rapidly expanding field with the development of new modalities and techniques. Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting - a new RT strategy delivering optimized dose redistribution...

journal_title：Cancer letters

authors： Shi X,Meng X,Sun X,Xing L,Yu J

更新日期：2014-12-28 00:00:00

abstract：:We evaluated the ability of brain-derived neurotrophic factor (BDNF) to decrease the chemosensitivity of neuroblastoma cells to cisplatin. Two cell lines, one derived from SH-SY5Y (SY5Y-TB8) and the other from SK-N-AS (AS-TB8), transfected with a TrkB plasmid were generated, and used to assess the effects of activatio...

journal_title：Cancer letters

authors： Jaboin J,Hong A,Kim CJ,Thiele CJ

更新日期：2003-04-10 00:00:00

abstract：:The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription...

journal_title：Cancer letters

authors： Platet N,Hinkel I,Richert L,Murdamoothoo D,Moufok-Sadoun A,Vanier M,Lavalle P,Gaiddon C,Vautier D,Freund JN,Gross I

更新日期：2017-02-01 00:00:00

abstract：:Associations between lung cancer risk and common polymorphisms in the DNA repair genes xeroderma pigmentosum complementation group D (XPD), X-ray repair cross-complementing group 1 (XRCC1), XRCC3 and apurinic/apyrimidinic endonuclease/redox factor 1 were examined within a randomized clinical trial designed to determin...

journal_title：Cancer letters

authors： Misra RR,Ratnasinghe D,Tangrea JA,Virtamo J,Andersen MR,Barrett M,Taylor PR,Albanes D

更新日期：2003-03-10 00:00:00

abstract：:Mammaglobin B is a recently-isolated gene speculated to belong to the uteroglobin gene family and is overexpressed in primary breast cancers. We investigated mammaglobin B mRNA expression in various cancers of the digestive system. Given the absence of mammaglobin B expression in normal lymph nodes, we also assessed t...

journal_title：Cancer letters

authors： Aihara T,Fujiwara Y,Miyake Y,Okami J,Okada Y,Iwao K,Sugita Y,Tomita N,Sakon M,Shiozaki H,Monden M

更新日期：2000-03-13 00:00:00

abstract：:The ability to induce changes in cell membrane properties is nowadays considered an additional mechanism to explain the pharmacological effects of non-steroidal anti-inflammatory drugs (NSAIDs). We previously demonstrated that the NSAID Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, triggers apoptosis in ...

journal_title：Cancer letters

authors： Tavolari S,Munarini A,Storci G,Laufer S,Chieco P,Guarnieri T

更新日期：2012-08-28 00:00:00

abstract：:The immunomodulatory and antimetastatic/antitumor activity of thymosin alpha(1) (Talpha(1)) was evaluated in BALB/c-mice. Daily subcutaneous application (7 consecutive days, 0.01-10 microg of Talpha(1)/injection per mouse) upregulated the number of thymocytes and peripheral blood cells in tumor bearing mice. To check ...

journal_title：Cancer letters

authors： Beuth J,Schierholz JM,Mayer G

更新日期：2000-10-16 00:00:00

abstract：:RNA interference (RNAi) is an evolutionary conserved mechanism for specific gene silencing. There are currently numerous cancer therapy clinical trials based on RNAi technology. Using an adenoviral system as a delivery mediator of RNAi, we investigated the therapeutic effects of targeting three genes simultaneously in...

journal_title：Cancer letters

authors： Han JB,Tao ZZ,Chen SM,Kong YG,Xiao BK

更新日期：2011-10-28 00:00:00

abstract：:The genomic aberration profile of chromosome 20q in distal CIN colon carcinomas was analysed using allelotyping and CGH arrays. Allelotyping revealed carcinomas with allelic imbalance along the full long arm, and carcinomas with fully non-aberrant 20q. Oligonucleotide-based CGH showed that among the carcinomas without...

journal_title：Cancer letters

authors： Nicolet C,Guérin E,Neuville A,Kerckaert JP,Wicker N,Bergmann E,Brigand C,Kedinger M,Gaub MP,Guenot D

更新日期：2009-09-18 00:00:00

abstract：:D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was...

journal_title：Cancer letters

authors： Yang YN,Chou KM,Pan WY,Chen YW,Tsou TC,Yeh SC,Cheung CH,Chen LT,Chang JY

更新日期：2011-10-01 00:00:00

abstract：:The role of mesothelial cells in the intraperitoneal spread of ovarian cancer is still elusive. In particular, it is unclear whether these cells constitute a passive barrier preventing cancer cell progression or perhaps act as an active promoter of this process. In this report we show that omental human peritoneal mes...

journal_title：Cancer letters

authors： Mikuła-Pietrasik J,Sosińska P,Kucińska M,Murias M,Maksin K,Malińska A,Ziółkowska A,Piotrowska H,Woźniak A,Książek K

更新日期：2014-12-28 00:00:00

abstract：:Epidemiologic studies and meta-analyses have suggested that patients with type 2 diabetes mellitus (T2DM) have a higher incidence of malignancies, including myeloma. Metformin is a widely prescribed antidiabetic drug. Recently, researchers have shown that metformin has direct anticancer activity against many tumor cel...

journal_title：Cancer letters

authors： Zi FM,He JS,Li Y,Wu C,Yang L,Yang Y,Wang LJ,He DH,Zhao Y,Wu WJ,Zheng GF,Han XY,Huang H,Yi Q,Cai Z

更新日期：2015-01-28 00:00:00

abstract：:Expression of cyclooxygenase (COX)-2 protein in preneoplastic and neoplastic lung lesions induced by the administration of 2000 ppm of N-nitrosobis(2-hydroxypropyl)amine (BHP) in the drinking water to Wistar male rats, was examined immunohistochemically. The majority of alveolar/bronchiolar adenomas (ADs) and all aden...

journal_title：Cancer letters

authors： Kitayama W,Denda A,Yoshida J,Sasaki Y,Takahama M,Murakawa K,Tsujiuchi T,Tsutsumi M,Konishi Y

更新日期：2000-02-01 00:00:00

abstract：:Nitrosatability of dried Nigerian vegetables and spices was investigated under simulated gastric conditions. N-Nitroso-dimethylamine (NDMA) was the only volatile nitrosamine found above the preformed level except in ugwu where N-nitroso-piperidine (2.3 ppb) was also detected. The lowest NDMA value of 0.4 ppb was found...

journal_title：Cancer letters

authors： Atawodi SE,Maduagwu EN,Preussmann R,Spiegelhalder B

更新日期：1991-05-24 00:00:00

abstract：:It has been nearly 9years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical inv...

journal_title：Cancer letters

authors： Shojaei F

更新日期：2012-07-28 00:00:00

abstract：:The identification of the breast cancer susceptibility genes BRCA1 and BRCA2 a few years ago has been greeted with great excitement and has raised hopes that they might illuminate the common mechanisms of this disease. Today we have to recognize that these expectations remain unfulfilled. Mutations in BRCA1 and BRCA2 ...

journal_title：Cancer letters

authors： Schwab M,Claas A,Savelyeva L

更新日期：2002-01-10 00:00:00

abstract：INTRODUCTION/HYPOTHESIS:Over-expression of the c-Met receptor tyrosine kinase has been described in a variety of cancers and implicated in tumor progression. Unlike some solid tumors, current evidence indicates that c-Met activation in colon cancer is unrelated to gene mutation, is ligand dependent, and occurs via a pa...

journal_title：Cancer letters

authors： Kammula US,Kuntz EJ,Francone TD,Zeng Z,Shia J,Landmann RG,Paty PB,Weiser MR

更新日期：2007-04-18 00:00:00

abstract：:Microtubule targeting based therapies have revolutionized cancer treatment; however, resistance and side effects remain a major limitation. Therefore, novel strategies that can overcome these limitations are urgently needed. We made a novel discovery that fisetin, a hydroxyflavone, is a microtubule stabilizing agent. ...

journal_title：Cancer letters

authors： Mukhtar E,Adhami VM,Sechi M,Mukhtar H

更新日期：2015-10-28 00:00:00

abstract：:As myeloma cells actively produce and secrete immunoglobulins, they are prone to ER stress, which if unresolved leads to apoptosis. We found that myeloma cell death induced by the ER stressor Thapsigargin was highly variable, ranging from 2 to 89%. Induction of ATF4 and CHOP was observed in myeloma cells under Thapsig...

journal_title：Cancer letters

authors： Gomez-Bougie P,Halliez M,Moreau P,Pellat-Deceunynck C,Amiot M

更新日期：2016-12-28 00:00:00

abstract：:The phenomenon of cellular dormancy has been observed in normal adult stem cells in many different tissues such as the skin, the intestine and the hematopoietic system. These dormant cells have been proposed to be important for life-long self-renewal and for the generation of the different cellular lineages. As tumor ...

journal_title：Cancer letters

authors： Schillert A,Trumpp A,Sprick MR

更新日期：2013-11-28 00:00:00

abstract：:Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing...

journal_title：Cancer letters

authors： Balassiano K,Lima S,Jenab M,Overvad K,Tjonneland A,Boutron-Ruault MC,Clavel-Chapelon F,Canzian F,Kaaks R,Boeing H,Meidtner K,Trichopoulou A,Laglou P,Vineis P,Panico S,Palli D,Grioni S,Tumino R,Lund E,Bueno-de-Mesqui

更新日期：2011-12-01 00:00:00

abstract：:The antagonism by 3 synthetic steroids of the induction of tyrosine aminotransferase and tryptophan dioxygenase by dexamethasone were compared in HTC and FAZA hepatoma cells and in isolated liver cells. It was observed: (i) the sensitivity of liver cells to glucocorticoid agonists and antagonists changed in relation t...

journal_title：Cancer letters

authors： Santana MA,Chasserot-Bolaz S,Beck B,Pogson CI

更新日期：1985-07-01 00:00:00

abstract：:Normal mouse vaginal epithelial cells isolated from ovariectomized ca. 40-day-old BALB/cCrg1 mice were purified by Percoll density gradient centrifugation and grown in primary culture using a collagen gel matrix and a serum-free complete medium. During the 9-day culture period, a 6-fold increase in cell number was obs...

journal_title：Cancer letters

authors： Uchima FD,Edery M,Iguchi T,Larson L,Bern HA

更新日期：1987-06-01 00:00:00

abstract：:Methylation of liver and nasal mucosal DNA at the O6 position of guanine (O6-MeG) was measured in intact and castrated male rats after a dose of N-nitrosobis(2-oxopropyl)amine (BOP) (20 mg/kg; i.p.). There were no differences in O6-MeG persistence in liver DNA from either group. In the nasal mucosa more O6-MeG was det...

journal_title：Cancer letters

authors： Lawson TA

更新日期：1990-08-01 00:00:00