Label retaining cells in cancer--the dormant root of evil?

abstract：:Fifteen samples from 11 patients suffering from chronic lymphocytic leukaemia (CLL; 5 untreated, 6 chemotherapeutically treated) were analysed for their individual gene expression of the multidrug resistance (MDR) associated genes encoding mdr1/P-glycoprotein, mrp, and topoisomerase II alpha/beta-isoenzymes by a compl...

journal_title：Cancer letters

authors： Beck J,Niethammer D,Gekeler V

更新日期：1994-10-28 00:00:00

abstract：:The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a lung carcinogen in the rat and believed to be a causative agent for lung cancer in smokers. To exert its carcinogenic potential NNK is metabolically activated by cytochrome P450-catalyzed alpha-hydroxylation. Nicotine and NNK s...

journal_title：Cancer letters

authors： Keyler D,Pentel PR,Kuehl G,Collins G,Murphy SE

更新日期：2003-12-08 00:00:00

abstract：:Hamster liver S9 prepared from control animals and animals given 30% glucose in drinking water 48 h before killing was used in studies of benzo[a]pyrene (BaP) and aflatoxin (AFB1)-induced mutagenesis, metabolism of BaP and AFB1, and metabolite binding to calf thymus DNA. BAP-induced mutagenesis in Salmonella typhimuri...

journal_title：Cancer letters

authors： Rubano DC,Teel RW,Strother A

更新日期：1990-07-16 00:00:00

abstract：:Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the non-chimeric siRNA. The chimeric PLK-1 siRNA inhibited MM cell pr...

journal_title：Cancer letters

authors： Kawata E,Ashihara E,Nakagawa Y,Kiuchi T,Ogura M,Yao H,Sakai K,Tanaka R,Nagao R,Yokota A,Takeuchi M,Kimura S,Hirai H,Maekawa T

更新日期：2010-08-28 00:00:00

abstract：:The age-standardized mortality rates by sex for cancer of all sites and some specific sites were calculated in the 22 areas of Rosario (Argentina). The rates by area were correlated with education, occupation, housing quality and population density, applying Kendall's tau. Cervical cancer rates showed the strongest co...

journal_title：Cancer letters

authors： Poletto L,Morini JC

更新日期：1990-03-01 00:00:00

abstract：:Resveratrol is a plant polyphenol found in grapes and red wine. It has been found to have beneficial effects on the cardiovascular system. Resveratrol also inhibits the growth of various tumor cell lines in vitro and inhibits carcinogenesis in vivo. In this study we examined the effect of resveratrol on growth of two ...

journal_title：Cancer letters

authors： Niles RM,McFarland M,Weimer MB,Redkar A,Fu YM,Meadows GG

更新日期：2003-02-20 00:00:00

abstract：:DDX1, a gene mapping to the 2p24 region, has been observed to be co-amplified with MYCN in neuroblastoma. Co-amplification of the DDX1 gene is a consequence of the short physical distance between the two genes. Recently, it has been found that neuroblastoma cells can show a low increase in MYCN gene copy number, defin...

journal_title：Cancer letters

authors： Defferrari R,Tonini GP,Conte M,Papio F,Sementa AR,Valent A,Schena F,Perri P,Mazzocco K

更新日期：2007-10-18 00:00:00

abstract：:B7-homolog 4 (B7-H4), a recently identified homolog of B7.1/2 (CD80/86), has been described to exert co-stimulatory and immune regulatory functions. We investigated the expression and the functional activity of B7-H4 in lung cancer in vitro and in vivo. Although a lung cancer cell line constitutively expressed B7-H4 m...

journal_title：Cancer letters

authors： Chen C,Qu QX,Shen Y,Mu CY,Zhu YB,Zhang XG,Huang JA

更新日期：2012-04-01 00:00:00

abstract：:TRIOBP isoforms 4 and 5 (TRIOBP-4/-5) are an actin-bundling protein associated with hearing loss. Here, we showed that TRIOBP-4/-5 was up-regulated in human pancreatic carcinoma cells. Knockdown of TRIOBP-4/-5 led to a loss of filopodia and a decrease in cell motility. Confocal microscopy showed that re-expression of ...

journal_title：Cancer letters

authors： Bao J,Wang S,Gunther LK,Kitajiri S,Li C,Sakamoto T

更新日期：2015-01-28 00:00:00

abstract：:CD271, known as a neurotrophin receptor, is expressed in various cancers such as hypopharyngeal cancer (HPC) and melanoma. We recently reported that CD271 is a cancer-stem-cell biomarker of HPC, and that its expression is essential for cancer-cell proliferation and is correlated with a poor prognosis in this disease. ...

journal_title：Cancer letters

authors： Morita S,Mochizuki M,Wada K,Shibuya R,Nakamura M,Yamaguchi K,Yamazaki T,Imai T,Asada Y,Matsuura K,Sugamura K,Katori Y,Satoh K,Tamai K

更新日期：2019-10-01 00:00:00

abstract：:To understand the role of cyclooxygenase-2 (COX-2) in gastric cancer, we examined the abundance of COX-2, vascular endothelial growth factor-A (VEGF-A), and CD34 in 45 surgically resected human gastric cancers and paired normal gastric mucosa by immunohistochemical analysis. In addition, the message RNA (mRNA) express...

journal_title：Cancer letters

authors： Yu HG,Li JY,Yang YN,Luo HS,Yu JP,Meier JJ,Schrader H,Bastian A,Schmidt WE,Schmitz F

更新日期：2003-05-30 00:00:00

abstract：:Radiofrequency ablation (RFA) is widely accepted as a first-line interventional oncology approach for hepatocellular carcinoma (HCC) and has the advantages of high treatment efficacy and low complication risk. Local control rates equivalent to hepatic resection can be reached by RFA alone when treating small HCCs (<2 ...

journal_title：Cancer letters

authors： Chen L,Sun J,Yang X

更新日期：2016-01-01 00:00:00

abstract：:RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...

journal_title：Cancer letters

authors： Landesman-Milo D,Goldsmith M,Leviatan Ben-Arye S,Witenberg B,Brown E,Leibovitch S,Azriel S,Tabak S,Morad V,Peer D

更新日期：2013-07-01 00:00:00

abstract：:Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Thus, in the current study, the ability of LIM and other monoterpe...

journal_title：Cancer letters

authors： Morse MA,Toburen AL

更新日期：1996-07-12 00:00:00

abstract：:Metastasis remains a formidable problem in malignant tumors. In this study, MTT assay revealed that 4-methyl-3-nitro-benzoic acid (MNBA) had no effect on cell viability and did not interfere with cell cycle in any breast cancer cell lines tested. However, treatment with MNBA on breast cancer cells can inhibit EGF-indu...

journal_title：Cancer letters

authors： Guo H,Li M,Chen P,Blake DJ,Kong X,Hao X,Niu R,Zhang N

更新日期：2011-06-01 00:00:00

abstract：:It has been nearly 9years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical inv...

journal_title：Cancer letters

authors： Shojaei F

更新日期：2012-07-28 00:00:00

abstract：:Ursodeoxycholic acid (UDCA) and its derivatives were examined for anti-angiogenic activities by using the chick embryo chorioallantoic membrane (CAM) assay. The presence of UDCA or its derivatives inhibited angiogenesis in a dose-dependent manner; the dose required for half-maximal inhibition (ID50) was 4 microg per C...

journal_title：Cancer letters

authors： Suh H,Jung EJ,Kim TH,Lee HY,Park YH,Kim KW

更新日期：1997-02-26 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce the risk of colorectal cancer (CRC). They are also known to induce the regression of colorectal adenomas, which are precursors to CRC. Despite these evidences, the exact mechanism by which NSAIDs exerts its anti-oncogenic effect is not completely...

journal_title：Cancer letters

authors： Gala M,Sun R,Yang VW

更新日期：2002-01-10 00:00:00

abstract：:In the course of screening for a novel inhibitor of cyclin-dependent kinase (CDK), HY52 (C17H30O2N2; molecular weight 294) was isolated from the leaves of Pata de Vaca (Bauhinia forficata). The growth of HeLa cells was inhibited in a dose-dependent manner when treated with 0.07 to 0.41 mM of HY52 for 24 h (IC50:0.11 m...

journal_title：Cancer letters

authors： Lim H,Kim MK,Lim Y,Cho YH,Lee CH

更新日期：2006-02-20 00:00:00

abstract：:In this study, we aimed to establish a platinum-based chemotherapy response and toxicity prediction model in advanced non-small cell lung cancer (NSCLC) patients. 416 single nucleotide polymorphisms (SNPs) in 185 genes were genotyped, and their association with drug response and toxicity were estimated using logistic ...

journal_title：Cancer letters

authors： Yin JY,Li X,Li XP,Xiao L,Zheng W,Chen J,Mao CX,Fang C,Cui JJ,Guo CX,Zhang W,Gao Y,Zhang CF,Chen ZH,Zhou H,Zhou HH,Liu ZQ

更新日期：2016-07-10 00:00:00

abstract：:We investigated the role of the 5-lipoxygenase (5-LOX) pathway of arachidonic acid metabolism in tumour necrosis factor-alpha (TNF-alpha)-induced differentiation of human leukemic HL-60 cells using MK-886, an inhibitor of 5-LOX activating protein. MK-886 augmented cell cycle arrest and differentiation induced by TNF-a...

journal_title：Cancer letters

authors： Stika J,Vondrácek J,Hofmanová J,Simek V,Kozubík A

更新日期：2006-06-18 00:00:00

abstract：:ArgBP2 is a multi-adapter protein involved in signal transduction associated to the cytoskeleton and was shown to regulate the migration and adhesion of pancreatic cancer cells thereby modulating their tumorigenicity. Here we describe the interaction of ArgBP2 with CIP4, a new associated protein identified by yeast tw...

journal_title：Cancer letters

authors： Roignot J,Taïeb D,Suliman M,Dusetti NJ,Iovanna JL,Soubeyran P

更新日期：2010-02-01 00:00:00

abstract：:Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...

journal_title：Cancer letters

authors： Zheng Y,Wang Z,Wei S,Liu Z,Chen G

更新日期：2021-02-28 00:00:00

abstract：:N-ethyl-N-nitrosourea-induced rat gliomas showed a stimulation of cytosolic spermidine N-acetyltransferase activity compared with normal brain, with an increased formation of N1 and N8-acetylspermidine, suggesting the activation of two enzymes acetylating the polyamine in N1 and N8 position, respectively. The enhancem...

journal_title：Cancer letters

authors： Sessa A,Broglia E,Terreni MR,Perin A

更新日期：1994-01-30 00:00:00

abstract：:The kinetics of total DNA adducts were compared in the liver, bladder epithelium and small intestinal epithelium of rats and mice following a single oral dose (100 mg/kg) of 3,3'-dichlorobenzidine [( 14C]DCB). Peak DNA binding (expressed as pmol DCB bound/mg DNA) in rat tissues was 153.5, 144.8 and 36.9 in the intesti...

journal_title：Cancer letters

authors： Ghosal A,Iba MM

更新日期：1990-09-01 00:00:00

abstract：:Endometrial cancer is one of the most common gynecologic malignancies and many factors influence in its growth and development. As in many other types of cancer, prostaglandin E(2) (PGE(2)) is thought to be an accelerator of cell proliferation and endometrial cancer progression. In this study, we examined the effect o...

journal_title：Cancer letters

authors： Takahashi T,Ogawa H,Izumi K,Uehara H

更新日期：2011-07-01 00:00:00

abstract：:In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Eucalyptus plants were screened. Consequently, the phlorogrucinol-monoterpene derivative, euglobal-G1 (EG-1), was obtained from the leaves of Eucalyptus grandis as an active constituent. EG-1 exhibited...

journal_title：Cancer letters

authors： Takasaki M,Konoshima T,Etoh H,Pal Singh I,Tokuda H,Nishino H

更新日期：2000-07-03 00:00:00

abstract：:The effect of pretreatment of skin of Sencar mice with topically applied tannic acid, quercetin and green tea polyphenols (GTP) on the skin tumor initiating activity of (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-2) has been evaluated. The animals were pretreated with ...

journal_title：Cancer letters

authors： Khan WA,Wang ZY,Athar M,Bickers DR,Mukhtar H

更新日期：1988-09-01 00:00:00

abstract：:Cytotoxic effects of 3-deazaguanosine (3-DGUO) result from the inhibition of DNA synthesis and incorporation of the drug into DNA. Synergistic antiproliferative effects of a combination of 3-deazaguanosine and 2-beta-D-ribofuranosylthiazole-4-carboxamide, a potent inhibitor of inosine monophosphate dehydrogenase, was ...

journal_title：Cancer letters

authors： Jacobsen SJ,Page T,Diala ES,Nyhan WL,Robins RK,Mangum JH

更新日期：1987-04-01 00:00:00

abstract：:Increased intramedullary apoptotic death of hematopoietic cells is thought to contribute to the ineffective hematopoiesis in myelodysplastic syndromes (MDS). Furthermore, high amounts of tumor necrosis factor alpha (TNF alpha) have previously been correlated with apoptosis in MDS marrows. The present studies were unde...

journal_title：Cancer letters

authors： Mundle SD,Reza S,Ali A,Mativi Y,Shetty V,Venugopal P,Gregory SA,Raza A

更新日期：1999-06-01 00:00:00