Abstract：
:ArgBP2 is a multi-adapter protein involved in signal transduction associated to the cytoskeleton and was shown to regulate the migration and adhesion of pancreatic cancer cells thereby modulating their tumorigenicity. Here we describe the interaction of ArgBP2 with CIP4, a new associated protein identified by yeast two-hybrid. We found that both proteins modulated their reciprocal tyrosine phosphorylation catalyzed by the non-receptor tyrosine kinase c-Abl. We observed that, like ArgBP2, CIP4 directly interacted with WAVE1 and could enhance its phosphorylation by c-Abl. ArgBP2 and CIP4 acted synergistically to increase WAVE1 tyrosine phosphorylation. Finally, we could show that CIP4 was dispensable for the ArgBP2 induced blockade of cell migration whereas its overexpression was deleterious for this important function of ArgBP2.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Roignot J,Taïeb D,Suliman M,Dusetti NJ,Iovanna JL,Soubeyran Pdoi
10.1016/j.canlet.2009.06.030subject
Has Abstractpub_date
2010-02-01 00:00:00pages
116-23issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(09)00456-Xjournal_volume
288pub_type
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