Abstract:
:Epidermal growth factor receptor (EGFR) is highly expressed in many human tumors including hepatocellular carcinoma (HCC). Therefore, inhibition of EGF receptors could be a potential target for anticancer therapy. In this study, we investigated the effects of two EGFR tyrosine kinase inhibitors, PD153035 and its analogue 4-[[3-chloro-4-fluorophenyl]amino]-6,7-dimethoxyquinazoline hydrochloride (ANAPD) on human HCC cell lines by cell proliferation assay, flow cytometry and Western blot. Our results demonstrated that both EGFR inhibitors inhibited tumor cell growth in a dose-dependent manner, but ANAPD was more potent than PD153035. These specific inhibitors not only blocked EGF-stimulated EGFR autophosphorylation but also targeted EGFR signaling including MAPK and Akt pathways. Furthermore, EGFR inhibitors induced a delay in cell cycle progression and a G(1) arrest together with a partial G(2)/M block. EGFR inhibitors also induced tumor cells to undergo apoptosis. In conclusion, this study demonstrated that both PD153035 and ANAPD inhibit tumor cell growth in HCC through inhibition of EGFR signaling pathway, and ANAPD is a more potent inhibitor than PD153035. This suggested that blockage of EGF receptors may provide an effective therapeutic approach for human HCC and ANAPD could be a potential drug candidate for the treatment of HCC.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Liu Y,Poon RT,Shao W,Sun X,Chen H,Kok TW,Fan STdoi
10.1016/j.canlet.2006.05.018subject
Has Abstractpub_date
2007-04-08 00:00:00pages
32-40issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(06)00395-8journal_volume
248pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Cervical cytology specimens prepared as monolayers were analyzed with a combination of high-resolution single-cell image analysis and lower-resolution contextual image analysis. For the latter, quantitative features of cluster architecture, object distribution and background were used to mimic the pathologists global ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90096-5
更新日期:1994-03-15 00:00:00
abstract::In this study, we aimed to establish a platinum-based chemotherapy response and toxicity prediction model in advanced non-small cell lung cancer (NSCLC) patients. 416 single nucleotide polymorphisms (SNPs) in 185 genes were genotyped, and their association with drug response and toxicity were estimated using logistic ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.04.029
更新日期:2016-07-10 00:00:00
abstract::Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.06.038
更新日期:2011-12-01 00:00:00
abstract::We have developed a simple system for rapid detection and measurement of glutathione S-transferase placental form (GSTP1) that detoxify polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, (RL34) cells. Survey of fruit extracts for GST inducing ability identified both papaya and a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00487-0
更新日期:2000-09-01 00:00:00
abstract::Vitamin C has been suggested and disputed as an anti-cancer agent. Previous in vitro studies using either primary cell cultures from cancer patients or tumor cell lines have suggested that tumor cells with different lineages may have different sensitivities to ascorbic acid. In this study we report characterization of...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90080-s
更新日期:1993-06-15 00:00:00
abstract::Given its contribution to malignant phenotypes of cancer, tumor hypoxia has been considered as a potential therapeutic problem. In the stressful microenvironment condition, hypoxia inducible factor 1 (HIF1) is well known to mediate the transcriptional adaptation of cells to hypoxia and acts as a central player for the...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.07.048
更新日期:2014-11-01 00:00:00
abstract::Gastric juice ascorbic acid concentrations were examined in black and white patients. Significantly lower concentrations were found in blacks, in the absence of a significant difference in the plasma concentration of vitamin C between races. Blacks had higher prevalence of Helicobacter pylori infection, higher gastric...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90336-0
更新日期:1994-08-15 00:00:00
abstract::Ellagic acid (EA) is a polyphenol found in several plants and fruits. The objectives of this study were to examine the molecular mechanisms by which EA inhibits pancreatic cancer growth in Balb C nude mice. PANC-1 cells were injected subcutaneously into Balb c nude mice, and tumor-bearing mice were treated with EA. Th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.05.009
更新日期:2013-09-01 00:00:00
abstract::Poly(ADP-ribose) synthetase activity in human cervical cancer cell nuclei was found to be approximately twice that of normal cervical cell nuclei. Using antipoly(ADP-ribose) antibody, frozen section of normal tissue were stained by indirect-immunofluorescence and it was demonstrated that the fluorescence of nuclei in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90148-8
更新日期:1981-12-01 00:00:00
abstract::Although end-binding protein 1 (EB1) is well known to regulate microtubule dynamics, the role of EB1 in apoptosis of non-small cell lung cancer (NSCLC) is poorly understood. Here, we investigated the molecular mechanism by which EB1 regulates apoptosis in H460, A549, and H1299 cells. Depletion of EB1 in A549 and H1299...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.07.027
更新日期:2013-10-01 00:00:00
abstract::Medroxyprogesterone acetate (MPA) is currently used therapeutically in the treatment of mammary and endometrial carcinomas. In order to develop a more potent and useful drug, we synthesized the novel compound, 9alpha-fluoromedoroxyprogesterone acetate (FMPA), by fluorinating MPA, and we also previously reported that F...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00375-x
更新日期:2000-06-01 00:00:00
abstract::Formation of DNA-adducts by 3-BHA or its metabolites, i.e., tert-butyl-1,4-benzoquinone (TBQ) and 5-methoxy-3-tert-butyl-1,2-benzoquinone (3-TBOQ), as well as DNA-adduct formation by 4-nitroquinoline-N-oxide (4NQO), in rat forestomach were examined by an enzymatic 32P-postlabeling assay. Four DNA-adducts were clearly ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90117-1
更新日期:1989-12-01 00:00:00
abstract::ArgBP2 is a multi-adapter protein involved in signal transduction associated to the cytoskeleton and was shown to regulate the migration and adhesion of pancreatic cancer cells thereby modulating their tumorigenicity. Here we describe the interaction of ArgBP2 with CIP4, a new associated protein identified by yeast tw...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.06.030
更新日期:2010-02-01 00:00:00
abstract::Monitoring angiogenesis is potentially an effective strategy for the early detection of cancer. In this study, early detection was achieved by evaluating blood vessel density in the liver using a three-dimensional contrast-enhanced high-frequency ultrasound (CE-HFUS) system and Sonazoid microbubbles. Three-dimensional...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.06.006
更新日期:2013-10-10 00:00:00
abstract::The aim of the study was to prove whether or not an association exists between the heat shock protein 70 (hsp70) and drug resistance. Tumor samples of 90 patients with previously untreated non-small lung carcinomas were investigated immunohistochemically for expression of resistance related proteins. Additionally, res...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03893-2
更新日期:1995-08-16 00:00:00
abstract::Urethane-induced lung tumors and their genetic changes were investigated in transgenic (Tg) mice carrying a human prototype c-Ha-ras gene (rasH2 mice). Male and female rasH2 mice and non-transgenic (non-Tg) littermates were injected intraperitoneally with 1000 mg/kg of urethane once or three times at 2-day intervals. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00372-4
更新日期:2000-05-29 00:00:00
abstract::Male and female transgenic mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and their wild littermates (non-Tg mice) received three subcutaneous injections of 0.3 mg N-methyl-N-nitrosourethane (MNUR) once every 2 weeks for the first 4 weeks followed by a single intraperitoneal injection of 1000 or 0 mg/kg ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00095-0
更新日期:1998-07-17 00:00:00
abstract::To define the critical region of liver-specific tumor suppressor genes in human hepatocellular carcinoma (HCC), we analyzed 30 cases of hepatocellular carcinoma using nine 4q and six 16q microsatellite polymorphic DNA markers. We observed one major common deleted region which was flanked by D4S175-D4S1625 and there ma...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00276-0
更新日期:1998-01-16 00:00:00
abstract::A single administration of enantiomerically pure 11,12-dihydrodiols of dibenzo[a,l]pyrene (DB[a,l]P) on the back of NMRI mice and subsequent chronic treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) (initiation/promotion assay) revealed strikingly different carcinogenic activities of both enantiomers. Tumor-in...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00265-1
更新日期:1999-03-01 00:00:00
abstract::Many clinical studies have shown that circulating RNA rises in cancer patients, but little is known about the origins of abnormally elevated extracellular RNA (exRNA). We designed four different culture conditions: serum-deprived, hypoxia, low temperature and exposure to an anticancer drug to investigate the origins i...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.09.016
更新日期:2008-01-18 00:00:00
abstract::The rationale for melanoma specific antitumor agents containing phenolic amines is based in part upon the ability of the enzyme tyrosinase to oxidize these prodrugs to toxic intermediates. Two phenolic amine compounds, N-acetyl-4-S-cysteaminylphenol (N-Ac-4-S-CAP) and 4-S-cysteaminylphenol (4-S-CAP), demonstrated grow...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90092-a
更新日期:1992-03-31 00:00:00
abstract::We have examined the expression of nitrotyrosine, a marker of peroxynitrite formation, in 55 esophageal cancers by immunohistochemistry. Nitrotyrosine was detected in 21 of 55 (38.2%) esophageal cancers. Comparison of nitrotyrosine expression and the pathological findings showed that there was a significant associatio...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00358-x
更新日期:2000-05-29 00:00:00
abstract::The mechanism of DDB (dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy biphenyl-2,2'-dicarboxylate) prevention of aflatoxin B1 (AFB1)-induced hepatotoxicity in rats has been investigated. Pretreatment of DDB (200 mg/kg) daily for 4 days significantly suppressed (P < 0.05) the AFB1-induced hepatic damage as evidenced...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03688-s
更新日期:1995-03-02 00:00:00
abstract::Epigenetics is defined as heritable changes in gene expression that occur without changes in DNA sequence. Major mechanisms of epigenetics are post-translational histone modifications such as reversible acetylation. Histone deacetylases (HDACs) maintain the acetylation level of histones but also act on non-histone sub...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2009.01.040
更新日期:2009-08-08 00:00:00
abstract::The immune repertoire (IR) refers to the sum of B cells and T cells with functional diversity in the circulatory system of one individual at any given time. Immune cells, which reside within microenvironments and are responsible for protecting the human body, include T cells, B cells, macrophages, and dendritic cells....
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.06.022
更新日期:2016-09-01 00:00:00
abstract::Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors. Many of the patients harbor insertion/deletion mutations in the hypermutable poly(C)(8) tract in exon 11 of the BHD gene. This mutational hot spot ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.06.005
更新日期:2007-04-08 00:00:00
abstract::Activation of the cytoplasmic (Ras-Raf-MEK-ERK) signaling cascade was shown to be both, necessary and sufficient for transformation in vitro as well as in vivo. However, over the last years the involvement of stress-activated protein kinases (SAPKs)/Jun N-terminal kinases (JNKs), and their substrate c-Jun in the proce...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.05.015
更新日期:2004-11-08 00:00:00
abstract::Angiogenesis remains a sensible target for pancreatic ductal adenocarcinoma (PDAC) therapy. VEGF, PDGF, FGF and their receptors are expressed at high levels and correlate with poor prognosis in human PDAC. Nintedanib is a triple angiokinase inhibitor that targets VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β signaling. We invest...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.12.027
更新日期:2015-03-01 00:00:00
abstract::We used selective biochemical markers of effect to evaluate some non-genotoxic cocarcinogenic properties of methyl thiophanate (MTH) associated with cytochrome P450 (CYP) changes. Several CYP-dependent reactions were monitored in the liver, kidney and lung microsomes of male and female Sprague-Dawley rats treated (i.p...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00298-5
更新日期:1999-01-29 00:00:00
abstract::The potential of gadolinium neutron-capture therapy (Gd-NCT) for cancer was evaluated using chitosan nanoparticles as a novel gadolinium device. The nanoparticles, incorporating 1200 microg of natural gadolinium, were administered intratumorally twice in mice bearing subcutaneous B16F10 melanoma. The thermal neutron i...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00388-2
更新日期:2000-03-31 00:00:00