Ascorbic acid, Helicobacter pylori and Lewis phenotype among blacks and whites in New Orleans.

Abstract:

:Gastric juice ascorbic acid concentrations were examined in black and white patients. Significantly lower concentrations were found in blacks, in the absence of a significant difference in the plasma concentration of vitamin C between races. Blacks had higher prevalence of Helicobacter pylori infection, higher gastric pH, more severe acute and chronic inflammation of the gastric mucosa and higher frequency of Lewis (a-b-) phenotype. Although most of these factors have been related to low ascorbic acid levels in gastric juice, none of them could account entirely for the difference between races either individually or after joint consideration. These observations may help to explain the high incidence of gastric carcinoma among the black population in southern Louisiana.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Ruiz B,Correa P,Fontham ET,Rood JC,Malcom GT,Torrado J,Perez A,Ramakrishnan T,Hunter FM

doi

10.1016/0304-3835(94)90336-0

subject

Has Abstract

pub_date

1994-08-15 00:00:00

pages

323-9

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(94)90336-0

journal_volume

83

pub_type

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