当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates.

A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates.

Abstract：

:We have developed a simple system for rapid detection and measurement of glutathione S-transferase placental form (GSTP1) that detoxify polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, (RL34) cells. Survey of fruit extracts for GST inducing ability identified both papaya and avocado as significant sources. Benzyl isothiocyanate (BITC) was isolated from papaya methanol extract as a principal inducer of GST activity. Further, the GST inducing ability of a total of 20 isothiocyanates (ITCs) and their derivatives was investigated. Some ITCs showed significant induction, and BITC was one of the most potent inducers among all compounds tested in the present study. The modification of isothiocyanate group (-NCS) or introduction of substituent group to the alpha-carbon modifies GST induction. Moreover, a significant correlation (P<0.01, r=0.913) between the GST activity enrichment and GSTP1 protein induction by ITCs was observed. We also indicated that phenethyl ITC and nitrophenyl ITC, potently inducing GST activity, but not inactive benzyl isocyanate, are potential inducers of intracellular reactive oxygen intermediates (ROIs). Our system of GSTP1 induction is appropriate for the chemical research such as screening and identification of novel type of inducers as well as the structure-activity relationship studies, providing mechanistic insight into essential structural elements for GSTP1 induction.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Nakamura Y,Morimitsu Y,Uzu T,Ohigashi H,Murakami A,Naito Y,Nakagawa Y,Osawa T,Uchida K

doi

10.1016/s0304-3835(00)00487-0

keywords:

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

193-200

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304383500004870

journal_volume

157

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Changes in the number of HSF1 positive granules in the nucleus reflects heat shock semiquantitatively.

    abstract：PURPOSE:The purpose of this study is to examine the changes in the number of HSF1 granules in the nucleus caused by different degree of heat stress. MATERIALS AND METHODS:A human esophageal cancer cell line, TE-2, was used. HSF1 granules were examined in an immunofluorescence study, and the changes in the average numb...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(03)00481-6

    authors： Nonaka T,Akimoto T,Mitsuhashi N,Tamaki Y,Nakano T

    更新日期：2003-12-08 00:00:00

  • Genetic damage and the inhibition of 7,12-dimethylbenz[a]anthracene-induced genetic damage by the phytoestrogens, genistein and daidzein, in female ICR mice.

    abstract：:Populations consuming soybeans have reduced rates of breast, colon and prostate cancer possibly due, in part, to the presence in soybeans of two estrogenic isoflavones, genistein and daidzein. This study investigated the genotoxicity of these soya isoflavones and their interactions with 7,12-dimethylbenz[a]anthracene ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03877-y

    authors： Giri AK,Lu LJ

    更新日期：1995-08-16 00:00:00

  • Novel anticancer compound [trifluoromethyl-substituted pyrazole N-nucleoside] inhibits FLT3 activity to induce differentiation in acute myeloid leukemia cells.

    abstract：:Anticancer properties of chemically synthesized compounds have continuously been optimized for better efficacy and selectivity. Derivatives of heterocyclic compounds are well known to have selective antiproliferative effect against many types of cancer. In this study, we investigated the ability of an indigenously syn...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.02.028

    authors： Saleh AM,Taha MO,Aziz MA,Al-Qudah MA,AbuTayeh RF,Rizvi SA

    更新日期：2016-06-01 00:00:00

  • Neuroblastoma targeting by c-myb-selective antisense oligonucleotides entrapped in anti-GD2 immunoliposome: immune cell-mediated anti-tumor activities.

    abstract：:Liposome encapsulation of anticancer agents results in reduced side effects of the entrapped drug and improved therapeutic efficacy. The external surface of the lipidic envelope can be coupled with antibodies directed against tumor-associated antigens. The resulting immunoliposomes allow to increase the therapeutic in...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2004.11.065

    authors： Brignole C,Marimpietri D,Pagnan G,Di Paolo D,Zancolli M,Pistoia V,Ponzoni M,Pastorino F

    更新日期：2005-10-18 00:00:00

  • Absence of beta-catenin gene mutations in pancreatic duct lesions induced by N-nitrosobis(2-oxopropyl)amine in hamsters.

    abstract：:The involvement of beta-catenin gene alterations in pancreatic duct carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters was examined by polymerase chain reaction-single strand conformation polymorphism analysis and the expression of beta-catenin protein was examined by immunohistochemistry. No m...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00406-2

    authors： Kubozoe T,Tsujiuchi T,Murata N,Sasaki Y,Tsunoda T,Konishi Y,Tsutsumi M

    更新日期：2001-07-10 00:00:00

  • Hyperthermia enhances tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line.

    abstract：:We have investigated the effects of hyperthermia on the apoptosis induced by tumor necrosis factor alpha (TNF-alpha). Confluent monolayers of human gastric cancer cell line MKN45 were either treated or untreated with hyperthermia for 1 h. The cells were subsequently stimulated with TNF-alpha. A 24-h incubation with TN...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(03)00463-4

    authors： Kokura S,Yoshida N,Ueda M,Imamoto E,Ishikawa T,Takagi T,Naito Y,Okanoue T,Yoshikawa T

    更新日期：2003-11-10 00:00:00

  • Binding of 1-nitro[14C]pyrene to DNA and protein in cultured lung macrophages and respiratory tissues.

    abstract：:Binding of 1-nitro[14C]pyrene (1-NP) or its metabolites to cellular DNA and protein in cultures of rabbit alveolar macrophages and lung and tracheal tissues was examined. DNA binding was highest in tracheal tissue (136.9 +/- 18.3 pmol 1-NP/mg DNA). DNA binding in macrophages and lung tissue was one-fifth of the level ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90091-5

    authors： King LC,Jackson M,Ball LM,Lewtas J

    更新日期：1983-07-01 00:00:00

  • Therapeutic efficiency of IL-2 gene transduced tumor vaccine for head and neck carcinoma.

    abstract：:Transduction of the human interleukin-2 (IL-2) gene into tumor cells was carried out in order to develop a new immunotherapy for advanced head and neck carcinomas with a poor outcome. We transduced the IL-2 gene into KB cells, a head and neck squamous cell carcinoma cell line, using a defective herpes simplex viral (H...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00336-0

    authors： Mizuno H,Yanoma S,Nishimura G,Hattori S,Ito T,Okudera K,Tsukuda M

    更新日期：2000-05-01 00:00:00

  • Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability.

    abstract：:Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors. Many of the patients harbor insertion/deletion mutations in the hypermutable poly(C)(8) tract in exon 11 of the BHD gene. This mutational hot spot ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2006.06.005

    authors： Jiang W,Fujii H,Matsumoto T,Ohtsuji N,Tsurumaru M,Hino O

    更新日期：2007-04-08 00:00:00

  • Simultaneous mitochondrial Ca(2+) overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells.

    abstract：:In this study, we investigated the role of Ca(2+) in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca(2+) overload selectively in the malignant breast cancer cells, but not in the normal breast cell, con...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2012.05.018

    authors： Yoon MJ,Kim EH,Kwon TK,Park SA,Choi KS

    更新日期：2012-11-28 00:00:00

  • Improved chemosensitivity in cervical cancer to cisplatin: synergistic activity of mahanine through STAT3 inhibition.

    abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.05.005

    authors： Das R,Bhattacharya K,Samanta SK,Pal BC,Mandal C

    更新日期：2014-08-28 00:00:00

  • Hyperthermia on immune regulation: a temperature's story.

    abstract：:Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory eff...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2008.05.026

    authors： Zhang HG,Mehta K,Cohen P,Guha C

    更新日期：2008-11-28 00:00:00

  • Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells.

    abstract：:In previous studies, we confirmed that mitofusin-2 (Mfn2) induced apoptosis in hepatocellular carcinoma (HCC) cells. However, the exact molecular mechanism remained unclear. Mfn2 expressed lower in tumour tissues, compared with adjacent non-cancer tissues. Furthermore, Mfn2 immunostaining was very weak in HCC tissue (...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.12.025

    authors： Wang W,Xie Q,Zhou X,Yao J,Zhu X,Huang P,Zhang L,Wei J,Xie H,Zhou L,Zheng S

    更新日期：2015-03-01 00:00:00

  • Antitumor activity of a novel nucleoside, 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine (CNDAC) against murine and human tumors.

    abstract：:The antitumor effects of 2'-C-cyano-2'-deoxy-1-beta-D- arabinofuranosylcytosine (CN-DAC), a synthetic 1-beta-D-arabinofuranosyl-cytosine (ara-C) derivative, were examined and compared with that of ara-C in murine tumors and in various human tumors using three different chemosensitivity tests. CNDAC extended the life s...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(92)90024-p

    authors： Tanaka M,Matsuda A,Terao T,Sasaki T

    更新日期：1992-05-30 00:00:00

  • Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone.

    abstract：:The molecular chaperone Hsp90 is not only of major current interest in fundamental biological research but also recognised as an exciting new target for the treatment of cancer and other diseases. In addition to playing an important role in response to proteotoxic heat shock and others stresses, Hsp90 is also critical...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2003.08.032

    authors： Workman P

    更新日期：2004-04-08 00:00:00

  • Preclinical comparison of regorafenib and sorafenib efficacy for hepatocellular carcinoma using multimodality molecular imaging.

    abstract：:Sorafenib has been used as a clinical targeted therapy for hepatocellular carcinoma (HCC) for more than a decade. In 2017, regorafenib was approved for HCC treatment and has since been reported to prolong the survival of advanced HCC patients after treatment failure with sorafenib. However, there has been no direct sy...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.03.037

    authors： Liu S,Du Y,Ma H,Liang Q,Zhu X,Tian J

    更新日期：2019-07-01 00:00:00

  • RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.

    abstract：:We previously identified Hop as over expressed in invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, suggesting an important role for Hop in the biology of invasive pancreatic cancer. Hop is a co-chaperone protein that binds to both Hsp70/Hsp90. We hypothesised that by targeting...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.03.004

    authors： Walsh N,Larkin A,Swan N,Conlon K,Dowling P,McDermott R,Clynes M

    更新日期：2011-07-28 00:00:00

  • Lumican core protein inhibits melanoma cell migration via alterations of focal adhesion complexes.

    abstract：:Lumican is a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM) with anti-tumor activity. We recently demonstrated that lumican inhibits the migration of melanoma cells and identified beta1 integrin as mediator of this effect [M.F. D'Onofrio, S. Brézillon, T. Baranek, C. Perreau, P.J. Roughley, F...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.03.032

    authors： Brézillon S,Radwanska A,Zeltz C,Malkowski A,Ploton D,Bobichon H,Perreau C,Malicka-Blaszkiewicz M,Maquart FX,Wegrowski Y

    更新日期：2009-09-28 00:00:00

  • Multi-drug resistance in cancer chemotherapeutics: mechanisms and lab approaches.

    abstract：:Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer chemotherapies. The mechanisms of MDR and the approaches to test MDR have been discovered, yet not fully understood. This review covers the in vivo and in vitro approaches for the detection of MDR in the laboratory and the mechanisms ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.03.013

    authors： Wu Q,Yang Z,Nie Y,Shi Y,Fan D

    更新日期：2014-06-01 00:00:00

  • Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia.

    abstract：:Cachexia, also known as wasting syndrome notably with skeletal muscle atrophy, costs nearly one-third of all cancer deaths in man. (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenolic component in green tea, is a potent preventive against cachexia as well as cancers. However, how EGCG counteracts cachexia...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.02.023

    authors： Wang H,Lai YJ,Chan YL,Li TL,Wu CJ

    更新日期：2011-06-01 00:00:00

  • Binding of [14C] azaserine to DNA and protein in the rat and hamster.

    abstract：:The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90092-1

    authors： Zurlo J,Coon CI,Longnecker DS,Curphey TJ

    更新日期：1982-05-01 00:00:00

  • Up-regulation of Foxp3 inhibits cell proliferation, migration and invasion in epithelial ovarian cancer.

    abstract：:The transcription factor Forkhead Box P3 (Foxp3) has been shown to play important roles in the occurring of regulatory T cells (Tregs). Limited evidence indicated that it was also expressed in tissues other than thymus and spleen, while, very recently, it was identified as a suppressor gene in breast cancer. However, ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.06.001

    authors： Zhang HY,Sun H

    更新日期：2010-01-01 00:00:00

  • Gut microbiota: A new piece in understanding hepatocarcinogenesis.

    abstract：:The gut microbiota forms a symbiotic relationship with the host and benefits the body in many critical aspects of life. However, immune system defects, alterations in the gut microbiota and environmental changes can destroy this symbiotic relationship and may lead to diseases, including cancer. Due to the anatomic and...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2020.01.002

    authors： Zhou A,Tang L,Zeng S,Lei Y,Yang S,Tang B

    更新日期：2020-04-01 00:00:00

  • Blood group specificity of pancreatic tumor mucin.

    abstract：:N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(80)90053-1

    authors： Runge RG,Pour P

    更新日期：1980-10-01 00:00:00

  • Differential modulation by dietary n-6 or n-9 unsaturated fatty acids on the development of two murine mammary gland tumors having different metastatic capabilities.

    abstract：:It is widely known that dietary lipids can modify the ability of different cancers to grow up and metastasize, especially mammary gland tumors. However, it is still unclear whether n-6 fatty acids behave as tumor promoters in this gland cell population. The effect of different nutritional polyunsaturated fatty acids (...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00534-x

    authors： Muñoz SE,Lopez CB,Valentich MA,Eynard AR

    更新日期：1998-04-24 00:00:00

  • Inhibition of development of preneoplastic lesions in the livers of rats fed a weakly carcinogenic environmental contaminant.

    abstract：:The effects of di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer and environmental contaminant, on the emergence of gamma-glutamyltrans-peptidase positive (GGT+) preneoplastic foci in the liver was investigated. Sprague--Dawley male rats initiated with diethylnitrosamine (DEN) following partial hepatectomy w...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90049-6

    authors： Deangelo AB,Garrett CT

    更新日期：1983-09-01 00:00:00

  • The inhibition of tumor growth by triplex-forming oligonucleotides.

    abstract：:We have previously shown that oligonucleotides designed to bind in triplex fashion to a specific p53 binding site homology inhibit the proliferation of colon cancer cells in vitro. The present study was designed to extend these observations in an in vivo model. HCT 116 human colon carcinoma cells were injected subcuta...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.02.002

    authors： Re RN,Cook JL,Giardina JF

    更新日期：2004-06-08 00:00:00

  • Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma.

    abstract：:Recent studies show that metabolic patterns typical of cancer cells, including aerobic glycolysis and increased lipogenesis, are not unique to malignancy, but rather originate in physiologic development. In the postnatal brain, where sufficient oxygen for energy metabolism is scrupulously maintained, neural progenitor...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.02.017

    authors： Tech K,Deshmukh M,Gershon TR

    更新日期：2015-01-28 00:00:00

  • Effect of sex and age on rectal cell renewal in humans.

    abstract：:We evaluated the influence of age and sex on rectal cell proliferation of 69 hospital controls and 66 patients with colorectal adenomas, by means of incubation of rectal biopsies with tritiated thymidine and autoradiography. In particular, we evaluated the labeling frequency in the upper 40% of rectal crypts (0 h), ac...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(90)90203-a

    authors： Paganelli GM,Santucci R,Biasco G,Miglioli M,Barbara L

    更新日期：1990-09-01 00:00:00

  • Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells.

    abstract：:Akt signaling pathway has attracted much attention as a promising target for cancer therapeutics. Herein, we report that Isobavachalcone (IBC), a natural chalcone, potently abrogates Akt signaling and exerts anti-proliferative effects on several human cancer cell lines. Modeling results from the Sybyl/FlexiDock progra...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2010.01.035

    authors： Jing H,Zhou X,Dong X,Cao J,Zhu H,Lou J,Hu Y,He Q,Yang B

    更新日期：2010-08-28 00:00:00