RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.

abstract：:Although brain tumors are classified as if their lineage were well understood, the relationship between the molecular events that specify neural cell lineage and brain tumors remains enigmatic. Traditionally, cell surface membrane antigens have served as biomarkers that distinguish brain tumor origin and malignancy. I...

journal_title：Cancer letters

authors： Seyfried NT,Huysentruyt LC,Atwood JA 3rd,Xia Q,Seyfried TN,Orlando R

更新日期：2008-05-18 00:00:00

abstract：:Two human cell lines, one established from a colon carcinoma (SW480) and the other from its lymph node metastasis (SW620), were compared with respect to their migration capacity employing a three-dimensional collagen matrix and time-lapse video recording. Non-motile cells were characterized by a round shape, whereas m...

journal_title：Cancer letters

authors： Kubens BS,Zänker KS

更新日期：1998-09-11 00:00:00

abstract：:Cervical cytology specimens prepared as monolayers were analyzed with a combination of high-resolution single-cell image analysis and lower-resolution contextual image analysis. For the latter, quantitative features of cluster architecture, object distribution and background were used to mimic the pathologists global ...

journal_title：Cancer letters

authors： Zahniser DJ,Isenstein LM,Hutchinson ML

更新日期：1994-03-15 00:00:00

abstract：:Several enzymes metabolize the toxic aldehydes produced during lipid peroxidation, such as 4-hydroxynonenal. During carcinogenesis induced by diethylnitrosamine in rat liver, an increase in aldehyde dehydrogenase, in comparison with normal liver, has already been shown. This paper demonstrates that, although to a less...

journal_title：Cancer letters

authors： Canuto RA,Muzio G,Maggiora M,Biocca ME,Dianzani MU

更新日期：1993-02-01 00:00:00

abstract：:Gelatinases play important roles in tumor progression and are abundantly expressed in a variety of malignant tumors. Antibody targeting gelatinases is a possible avenue to fight against cancer. However, antibody alone can not achieve curative efficacy. Herein, we demonstrated the intensified targeting therapy of a tan...

journal_title：Cancer letters

authors： Zhong G,Zhang S,Li Y,Liu X,Gao R,Miao Q,Zhen Y

更新日期：2010-09-01 00:00:00

abstract：:Immunometabolism, which has important implications in cancer biology, has emerged as a major regulator of different immune cell types. Various factors that integrate metabolic switches within immune cells with signal directed program that promote or inhibit their functions remain largely unidentified. Furthermore, sex...

journal_title：Cancer letters

authors： Zi Xu YX,Ande SR,Mishra S

更新日期：2018-02-28 00:00:00

abstract：:Costunolide (CT), a sesquiterpene lactone constituent isolated from Saussurea lappa (Compositae), exerted an antiangiogenic effect. CT selectively inhibited the endothelial cell proliferation induced by vascular endothelial growth factor (VEGF). Further, CT was also found to inhibit the VEGF-induced chemotaxis of huma...

journal_title：Cancer letters

authors： Jeong SJ,Itokawa T,Shibuya M,Kuwano M,Ono M,Higuchi R,Miyamoto T

更新日期：2002-12-10 00:00:00

abstract：:Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is ubiquitously present in eukaryotic cells and archebacteria. In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate. Hydroxylation of the d...

journal_title：Cancer letters

authors： Chen ZP,Chen KY

更新日期：1997-05-19 00:00:00

abstract：:Pancreatic adenocarcinoma cells show characteristics of macrophages as phagocytosis and exocytosis. These phagocytic activities can be inhibited in macrophages by antirheumatic drugs, e.g. gold compounds and antimalarials. We have now tested the activity of auranofin and chloroquine to inhibit growth of a pancreatic t...

journal_title：Cancer letters

authors： Zeilhofer HU,Mollenhauer J,Brune K

更新日期：1989-01-01 00:00:00

abstract：:In esophageal squamous cell carcinoma (SCC), we used immunohistochemical analysis to further elucidate the correlation of p53 protein expression with clinicopathological factors, as well as with risk factors, such as tobacco smoking, alcohol consumption and a family history of cancer, using odds ratios (ORs). The expr...

journal_title：Cancer letters

authors： Kato H,Yoshikawa M,Miyazaki T,Nakajima M,Fukai Y,Tajima K,Masuda N,Tsukada K,Fukuda T,Nakajima T,Kuwano H

更新日期：2001-06-10 00:00:00

abstract：:Radiation therapy has become an important tool in the treatment of cancer patients, but most patients relapse within 5 years. Relapse is due to the presence of cancer stem cells (CSCs), but the molecular mechanism of radioresistance in CSCs remains largely elusive. Here, we found that irradiation-resistant (IR) cells ...

journal_title：Cancer letters

authors： Shi Y,Liu N,Lai W,Yan B,Chen L,Liu S,Liu S,Wang X,Xiao D,Liu X,Mao C,Jiang Y,Jia J,Liu Y,Yang R,Cao Y,Tao Y

更新日期：2018-05-28 00:00:00

abstract：:The effect of selenium was examined on the growth potential of normal, preneoplastic and neoplastic mammary cells grown in primary monolayer cell cultures and on 3 established mammary cell lines. Selenium, present as Na2SeO3 in serum-free DMEM, inhibited all mammary cell cultures at 1 x 10(-5) M. Selenium, at 5 x 10(-...

journal_title：Cancer letters

authors： Medina D,Oborn CJ

更新日期：1981-09-01 00:00:00

abstract：:Development of drug resistance to standard chemotherapy is a common phenomenon that leads to poor prognosis in patients. Thus, novel agents that can attenuate chemoresistance are urgently needed. Therefore, we analyzed whether isorhamnetin (IH), a 3'-O-methylated metabolite of quercetin, can enhance the potential effi...

journal_title：Cancer letters

authors： Manu KA,Shanmugam MK,Ramachandran L,Li F,Siveen KS,Chinnathambi A,Zayed ME,Alharbi SA,Arfuso F,Kumar AP,Ahn KS,Sethi G

更新日期：2015-07-10 00:00:00

abstract：:Orlistat is an anti-obesity agent that increases the fecal fat excretion, which promotes colon carcinogenesis. Therefore, the present study was designed to verify the effects of Orlistat on the formation of rat colonic aberrant crypt foci (ACF) and cell proliferation evaluated by the PCNA method. Male Wistar rats rece...

journal_title：Cancer letters

authors： Garcia SB,Barros LT,Turatti A,Martinello F,Modiano P,Ribeiro-Silva A,Vespúcio MV,Uyemura SA

更新日期：2006-08-28 00:00:00

abstract：:We assessed whether current therapies could lead to hematogenous dissemination of malignant hepatocytes in hepatocellular carcinoma (HCC) patients using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) for alpha-fetoprotein (afp) and albumin (alb) mRNAs. We analyzed 137 peripheral blood sampl...

journal_title：Cancer letters

authors： Wong IH,Yeo W,Leung T,Lau WY,Johnson PJ

更新日期：2001-06-26 00:00:00

abstract：:Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression b...

journal_title：Cancer letters

authors： Ogawa S,Kaku T,Kobayashi H,Hirakawa T,Ohishi Y,Kinukawa N,Nakano H

更新日期：2002-02-08 00:00:00

abstract：:Under most circumstances, hepatitis B virus (HBV) is noncytopathic. However, hepatocellular regeneration that accompanies each bout of hepatitis appears to be associated with increased integration of HBV DNA fragments expressing the virus encoded hepatitis B x antigen (HBxAg). Intrahepatic HBxAg staining correlates wi...

journal_title：Cancer letters

authors： Feitelson MA,Reis HM,Tufan NL,Sun B,Pan J,Lian Z

更新日期：2009-12-01 00:00:00

abstract：:Pancreatic cancer cells are usually resistant to apoptosis mediated by tumor necrosis factor (TNF)-alpha or FasL, and their toxicity towards normal cells hampers their application for therapeutic use. TNF-related apoptosis-inducing ligand (TRAIL), a novel member of the TNF family, triggers apoptosis in a variety of ma...

journal_title：Cancer letters

authors： Ozawa F,Friess H,Kleeff J,Xu ZW,Zimmermann A,Sheikh MS,Büchler MW

更新日期：2001-02-10 00:00:00

abstract：:We have examined the effect of protease inhibitors on radiation-induced DNA amplification in vitro using an SV40-transformed Chinese hamster embryo cell line. DNA from cells irradiated with X-rays (10 Gy) or ultraviolet radiation (8 J/m2) resulted in an 8-fold or greater amplification of SV40 sequences compared with u...

journal_title：Cancer letters

authors： Flick MB,Kennedy AR

更新日期：1991-02-01 00:00:00

abstract：:Expression of the MUC2 gene is controlled by the methylation of CpG sites in the promoter region, but the detailed methylation status of this region has yet to be reported. We have mapped the complete methylation status of the MUC2 promoter from position -1989 to position +288 upstream, a region that contains 59 CpG s...

journal_title：Cancer letters

authors： Hamada T,Goto M,Tsutsumida H,Nomoto M,Higashi M,Sugai T,Nakamura S,Yonezawa S

更新日期：2005-09-28 00:00:00

abstract：:When injected into female NMRI mice tumour necrosis factor-alpha (TNF) produced a dose-related weight loss over the first 24 h, which was accompanied by and directly proportional to a decrease in both food and water intake. Body composition analysis after the first 8 h revealed that the weight loss was associated with...

journal_title：Cancer letters

authors： Mahony SM,Tisdale MJ

更新日期：1989-06-01 00:00:00

abstract：:Insertion of functional interleukin-2 (IL-2) gene into a plasmacytoma cell line X63-Ag8.653 substantially reduced tumorigenicity of the resulting cloned cells, designated as X63-m-IL-2. Peritumoral administration of the X63-m-IL-2 cells, producing constitutively large quantities of IL-2, resulted in regressions of est...

journal_title：Cancer letters

authors： Bubeník J,Lotzová E,Indrová M,Símová J,Jandlová T,Bubeníková D

更新日期：1992-03-15 00:00:00

abstract：:The plant species Ephedra is commonly used in both folk medicine and for the preparation of health teas. Nitrosation of a tea made from Ephedra altissima yielded N-nitrosoephedrine (NEP), N-nitrosopseudoephedrine (NPEP), N-nitrosoproline (NPRO), N-nitrosomethylbenzylamine (NMBA), trace quantities of 2 unidentified non...

journal_title：Cancer letters

authors： Tricker AR,Wacker CD,Preussmann R

更新日期：1987-05-01 00:00:00

abstract：:The molecular chaperone Hsp90 is not only of major current interest in fundamental biological research but also recognised as an exciting new target for the treatment of cancer and other diseases. In addition to playing an important role in response to proteotoxic heat shock and others stresses, Hsp90 is also critical...

journal_title：Cancer letters

authors： Workman P

更新日期：2004-04-08 00:00:00

abstract：:Diet is one of the elements that may influence the development of lung cancer. To ascertain the relationship between meat and fish consumption and the appearance of this disease, a case-control study was conducted on a population in Galicia (NW Spain), with a sample of 295 cases and 322 controls. All cases had histolo...

journal_title：Cancer letters

authors： Dosil-Díaz O,Ruano-Ravina A,Gestal-Otero JJ,Barros-Dios JM

更新日期：2007-07-08 00:00:00

abstract：:The cell inactivating effect of cis-dichlorodiammineplatinum(II) in combination with 2-substituted benzaldehyde derivatives was tested using cultured human NHIK 3025 cells. Simultaneous drug combination with benzaldehyde protected cells from cis-DDP-induced cell inactivation in a dose-dependent manner. Substitution wi...

journal_title：Cancer letters

authors： Dornish JM,Pettersen EO

更新日期：1989-07-01 00:00:00

abstract：:Dihydroambazone (DHA) is a water-soluble derivative of the experimental anticancer drug ambazone. In vitro, a combination of DHA and human recombinant tumor necrosis factor alpha (TNF) exerted a strong synergism of cytotoxicity against both mouse melanoma B16K cells and the TNF-sensitive mouse fibroblast line L-M (S)....

journal_title：Cancer letters

authors： Baumgart J,Gase K,Schulze W,Suehnel J,Gutsche W,Behnke D

更新日期：1990-11-05 00:00:00

abstract：:The incidence of pediatric cancers is rising steadily across the world, along with the challenges in understanding the molecular mechanisms and devising effective therapeutic strategies. Pediatric cancers are presented with diverse molecular characteristics and more distinct subtypes when compared to adult cancers. Re...

journal_title：Cancer letters

authors： Vellichirammal NN,Chaturvedi NK,Joshi SS,Coulter DW,Guda C

更新日期：2021-02-28 00:00:00

abstract：:The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...

journal_title：Cancer letters

authors： Miyata Y,Fukushima S,Imaida K,Ito N

更新日期：1984-07-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe H...

journal_title：Cancer letters

authors： Pérez-Sayáns M,Suárez-Peñaranda JM,Pilar GD,Barros-Angueira F,Gándara-Rey JM,García-García A

更新日期：2011-12-26 00:00:00