Multi-drug resistance in cancer chemotherapeutics: mechanisms and lab approaches.

abstract：:The mucosal glutathione content of the gastrointestinal wall amounted to 50-60% of its concentration in the liver. GSH S-aryltransferase activity (CDNB) was very low in the glandular stomach, colon and rectum amounting to only 5% of liver enzyme activity. There was a marked postpyloric increase in GSH S-aryltransferas...

journal_title：Cancer letters

authors： Siegers CP,Riemann D,Thies E,Younes M

更新日期：1988-05-01 00:00:00

abstract：:Homeobox genes, involved in embryonic development and tissues homeostasis in adults, are often deregulated in cancer, but their relevance in pathology is far from being fully elucidated. In colon cancers, we report that the homeoproteins HoxB7 and Cdx2 exhibit different heterogeneous patterns, Cdx2 being localized in ...

journal_title：Cancer letters

authors： Soret C,Martin E,Duluc I,Dantzer F,Vanier M,Gross I,Freund JN,Domon-Dell C

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:The purpose of this study is to examine the changes in the number of HSF1 granules in the nucleus caused by different degree of heat stress. MATERIALS AND METHODS:A human esophageal cancer cell line, TE-2, was used. HSF1 granules were examined in an immunofluorescence study, and the changes in the average numb...

journal_title：Cancer letters

authors： Nonaka T,Akimoto T,Mitsuhashi N,Tamaki Y,Nakano T

更新日期：2003-12-08 00:00:00

abstract：:Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family, essential for mitotic spindle dynamics and centrosome integrity during mitosis. Mounting evidence suggests that deregulation of TACC3 is associated with various types of human cancer. However, the molecular mechanisms by which TACC3 cont...

journal_title：Cancer letters

authors： Ha GH,Park JS,Breuer EK

更新日期：2013-05-10 00:00:00

abstract：:Classical Hodgkin lymphoma (cHL) tumor cells are surrounded by a protective tumor microenvironment (TME). Trabectedin, an anticancer drug targeting both tumor cells and TME, demonstrated a potent antitumor activity against Hodgkin Reed Sternberg (HRS) cells. It was cytotoxic against cHL cell lines, including the doxor...

journal_title：Cancer letters

authors： Casagrande N,Borghese C,Favero A,Vicenzetto C,Aldinucci D

更新日期：2021-03-01 00:00:00

abstract：:The primary aim of this study was to find novel chemopreventive agents effective against breast cancer. Endoplasmic reticulum (ER) stress can induce apoptosis through the unfolded protein response (UPR). 2'-Hydroxy-2,3,5'-trimethoxychalcone (DK143) is a synthetic flavonoid derivative. The present study provides eviden...

journal_title：Cancer letters

authors： Lee DH,Jung Jung Y,Koh D,Lim Y,Lee YH,Shin SY

更新日期：2016-03-01 00:00:00

abstract：:Various dose levels of benzo[a]pyrene (BP) were tested on short-term cultured foetal hamster lung cells for transforming effects in vitro in 6 similar experiments. The statistical evaluation of the results indicated a weak reproducibility (P = 0.09). Factors which inherently influence such reproducibility were conside...

journal_title：Cancer letters

authors： Richter-Reichhelm HB,Emura M,Schneider P,Mohr U

更新日期：1979-11-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2), a member of the HER family of tyrosine kinases and a binding partner of Heat shock protein 90 (Hsp90), is found amplifies in approximately 25% breast cancers. Treatment of HER2+ breast cancers has been greatly improved in recent years, but the accompanying upregulation ...

journal_title：Cancer letters

authors： Huang W,Wu QD,Zhang M,Kong YL,Cao PR,Zheng W,Xu JH,Ye M

更新日期：2015-01-28 00:00:00

abstract：:The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor development. Low oxygen concentration influences cellular metabolism and, thus, affects proliferation, migration, and invasion. A focal point of the cell's adaptation to hypoxia is the transcription factor HIF1α (hypoxia-inducible ...

journal_title：Cancer letters

authors： Paredes F,Williams HC,San Martin A

更新日期：2021-01-11 00:00:00

abstract：:Nitrosamine formation from the reaction of nitroprusside with morpholine was found to be a light-dependent reaction. Maximum nitrosation occurred when the reactants were exposed to UV light (lambda = 275-300 nm). However, considerable nitrosation also occurred with light in the visible spectrum up to 500 nm. No signif...

journal_title：Cancer letters

authors： Cooney RV,Ramseyer J,Ross PD

更新日期：1988-06-15 00:00:00

abstract：:Normal tissue injury may lead to severe, life threatening, late side effects after therapeutic use of irradiation. Neurological complications caused by radiation of the spinal cord are ascribed to progressive, irreversible damage to the vasculature. Hyperbaric oxygen (HBO) is known to induce angiogenesis in irradiated...

journal_title：Cancer letters

authors： Sminia P,van der Kleij AJ,Carl UM,Feldmeier JJ,Hartmann KA

更新日期：2003-02-28 00:00:00

abstract：:The pineal has been recently implicated in mammary tumorigenesis. Effect of physiological pinealectomy brought about by subjecting female Holtzman rats to permanent lighting (24 h/day) from birth was studied on the incidence of 9,10-dimethyl-1,2-benzanthracene (DMBA) induced mammary tumors. The incidence of adenocarci...

journal_title：Cancer letters

authors： Kothari LS,Shah PN,Mhatre MC

更新日期：1982-09-01 00:00:00

abstract：:TRIOBP isoforms 4 and 5 (TRIOBP-4/-5) are an actin-bundling protein associated with hearing loss. Here, we showed that TRIOBP-4/-5 was up-regulated in human pancreatic carcinoma cells. Knockdown of TRIOBP-4/-5 led to a loss of filopodia and a decrease in cell motility. Confocal microscopy showed that re-expression of ...

journal_title：Cancer letters

authors： Bao J,Wang S,Gunther LK,Kitajiri S,Li C,Sakamoto T

更新日期：2015-01-28 00:00:00

abstract：:The limitations of current chemotherapies have motivated research in developing new treatments. Growing evidence shows that interaction between tumors and their microenvironment, but not tumor cells per se, is the key factor in tumor progression and therefore of obvious scientific interest and therapeutic value. Exoso...

journal_title：Cancer letters

authors： Tang MK,Wong AS

更新日期：2015-10-10 00:00:00

abstract：:Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-B...

journal_title：Cancer letters

authors： Shimizu M,Ishii H,Ogo N,Unno Y,Matsuno K,Sawada J,Akiyama Y,Asai A

更新日期：2010-12-01 00:00:00

abstract：:As the frequent emergency of resistant tumor cells during treatment, the development of new agents with new modes of action attracts a great deal of interest. Polybia-MPI was a short cationic alpha-helical amphiphilic peptide that has selective toxicity toward cancer cells but no hemolytic activity. Its target selecti...

journal_title：Cancer letters

authors： Wang KR,Yan JX,Zhang BZ,Song JJ,Jia PF,Wang R

更新日期：2009-06-08 00:00:00

abstract：:Application of functional imaging to radiotherapy (RT) is a rapidly expanding field with the development of new modalities and techniques. Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting - a new RT strategy delivering optimized dose redistribution...

journal_title：Cancer letters

authors： Shi X,Meng X,Sun X,Xing L,Yu J

更新日期：2014-12-28 00:00:00

abstract：:A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic str...

journal_title：Cancer letters

authors： Grosso LE,Pitot HC

更新日期：1984-02-01 00:00:00

abstract：:Patients with Her2-positive breast cancer exhibit de novo resistance or develop acquired resistance in less than one year after Her2 targeting treatment, but the mechanism is not fully elucidated. Compensatory pathways such as the IGF-1R/IRS-1 pathway, are activated, leading to aberrant enhanced PI3K/Akt/mTOR pathway ...

journal_title：Cancer letters

authors： Qiu N,He YF,Zhang SM,Zhan YT,Han GD,Jiang M,He WX,Zhou J,Liang HL,Ao X,Xia HM,Li J,Yang YY,He ZM,Zou ZZ,Li HS

更新日期：2019-11-01 00:00:00

abstract：:Berberine, an isoquinoline alkaloid, has a wide range of pharmacological effects, including anti-inflammation, yet the exact mechanism is unknown. Because cyclooxygenase-2 (COX-2) plays a key role in prostaglandins (PGs) synthesis, which is elevated in inflammation, we examined whether the anti-inflammatory mechanism ...

journal_title：Cancer letters

authors： Kuo CL,Chi CW,Liu TY

更新日期：2004-01-20 00:00:00

abstract：:Autophagy is a membrane process that results in the transporting of cellular contents to lysosomes for degradation. Autophagic cell death is another way of programed cell death called type II PCD, which has complicated connection with apoptosis, both of these two types of cell death play an important role in tumor dev...

journal_title：Cancer letters

authors： Xiong HY,Guo XL,Bu XX,Zhang SS,Ma NN,Song JR,Hu F,Tao SF,Sun K,Li R,Wu MC,Wei LX

更新日期：2010-02-01 00:00:00

abstract：:Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression b...

journal_title：Cancer letters

authors： Ogawa S,Kaku T,Kobayashi H,Hirakawa T,Ohishi Y,Kinukawa N,Nakano H

更新日期：2002-02-08 00:00:00

abstract：:The phthalocyanines are a new class of photosensitizers with promising properties for use in photodynamic therapy of cancer [E. Ben-Hur and I. Rosenthal (1985) Int. J. Radiat. Biol., 47, 145--147]. The ability of aluminum phthalocyanine tetrasulfonate (AlPCS) to cause membrane damage upon light exposure was tested usi...

journal_title：Cancer letters

authors： Ben-Hur E,Rosenthal I

更新日期：1986-03-01 00:00:00

abstract：:The formation of nitroso compounds and mutagens from 5 nitrogen-containing drugs (cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide) by drug/nitrite interaction was examined. On the reaction of 50 micrometers drug and 500 micrometers nitrite at pH 3.0--3.4 and 37 degrees C for 4 h, the conside...

journal_title：Cancer letters

authors： Takeda Y,Kanaya H

更新日期：1982-01-01 00:00:00

abstract：:MICAL2 is a tumor-promoting factor involved in cell migration, invasion, deformation, and proliferation not yet fully explored in lung adenocarcinoma (LUAD). This study demonstrated that MICAL2 was overexpressed and cytoplasm-enriched in LUAD tissues. Moreover, high cytoplasmic MICAL2 and/or total MICAL2 expression le...

journal_title：Cancer letters

authors： Zhou W,Liu Y,Gao Y,Cheng Y,Chang R,Li X,Zhou Y,Wang S,Liang L,Duan C,Zhang C

更新日期：2020-07-28 00:00:00

abstract：:The anticarcinogenic action of the garlic constituent diallyl sulfide (DAS), was examined in the hamster buccal pouch and forestomach. Groups of hamsters were topically treated, for up to 14 weeks, with a 0.5% solution of the buccal pouch and forestomach carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Prior to, duri...

journal_title：Cancer letters

authors： Nagabhushan M,Line D,Polverini PJ,Solt DB

更新日期：1992-10-21 00:00:00

abstract：:As a promising method for local tumor treatment, nanosecond pulsed electric field (nsPEF) ablation elicits a potent anti-tumor immune response. However, the mechanism of the nsPEF-mediated anti-tumor immune response and its effects on the tumor microenvironment remains unclear. Here, we demonstrated that nsPEF treatme...

journal_title：Cancer letters

authors： Qian J,Chen T,Wu Q,Zhou L,Zhou W,Wu L,Wang S,Lu J,Wang W,Li D,Xie H,Su R,Guo D,Liu Z,He N,Yin S,Zheng S

更新日期：2020-12-28 00:00:00

abstract：:The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 a...

journal_title：Cancer letters

authors： An MJ,Cheon JH,Kim SW,Kim ES,Kim TI,Kim WH

更新日期：2009-06-28 00:00:00

abstract：:Pancreatic cancer is one of the most aggressive malignancies and has been considered poorly immunogenic for decades. However, this characterization might be over-simplistic. A more sophisticated approach is needed in order to develop new treatment strategies. In this review, we will focus on T cell exhaustion as a phe...

journal_title：Cancer letters

authors： Bauer C,Kühnemuth B,Duewell P,Ormanns S,Gress T,Schnurr M

更新日期：2016-10-10 00:00:00

abstract：:Treatment of human epidermoid carcinoma A431 cells with transplatin (trans-DDP) and beta-hydroxyisovalerylshikon (beta-HIVS) together had a strong inhibitory effect on A431 cells. By contrast, trans-DDP and beta-HIVS by themselves, at the same respective concentrations, had practically no effect. The tyrosine kinase a...

journal_title：Cancer letters

authors： Xu Y,Nakajo S,Nakaya K

更新日期：2002-12-15 00:00:00