Synergistic inhibitory effects of transplatin and beta-hydroxyisovalerylshikon on carcinoma A431 cells involve epidermal growth factor receptor.

abstract：:Telomerase, a critical enzyme responsible for continuous cell growth, is repressed in most somatic cells except proliferating progenitor cells and activated lymphocytes, and activated in approximately 85% of human cancer tissues. Telomerase activity is a useful cancer-cell detecting marker in some types of cancers in ...

journal_title：Cancer letters

authors： Hiyama E,Hiyama K

更新日期：2003-05-15 00:00:00

abstract：:The recurrence rate of soft tissue and bone sarcomas strongly correlates to the status of the surgical margin after excision, yet excessive removal of tissue may lead to distinct, otherwise avoidable morbidity. Therefore, adequate margination of sarcomas both pre- and intra-operatively is a clinical necessity that has...

journal_title：Cancer letters

authors： Baljer BC,Kolhe S,Chan CD,Nicoli F,Ghanbasha A,Brookes MJ,Gamie Z,Ghosh KM,Beckingsale TB,Saleh DB,Ragbir M,Gerrand CH,Jeys L,Knight JC,Petrides G,Rankin KS

更新日期：2020-07-28 00:00:00

abstract：:Survivin, a novel antiapoptosis gene, was identified as a member of the inhibitor of apoptosis protein (IAP) family. Unique among IAP, survivin has been found to be abundantly expressed in a wide variety of human malignancies, whereas it is undetectable in normal adult tissues. Recently, three splicing variants of sur...

journal_title：Cancer letters

authors： Meng H,Lu C,Mabuchi H,Tanigawa N

更新日期：2004-12-28 00:00:00

abstract：:Previous studies point to protein kinase C (PKC) isozyme eta as a resistance factor in cancer cells. Therefore, we investigated whether down-regulation of PKCeta with second generation antisense oligonucleotides (ODNs) would sensitise A549 human lung carcinoma cells to cytostatics. The effects were compared to the out...

journal_title：Cancer letters

authors： Sonnemann J,Gekeler V,Ahlbrecht K,Brischwein K,Liu C,Bader P,Müller C,Niethammer D,Beck JF

更新日期：2004-06-25 00:00:00

abstract：:The effect of bile acids on the formation of azoxymethane induced aberrant crypt foci (ACF) was investigated using the fecal stream-excluded colons of colostomized F344 rats. The excluded colon was irrigated with saline or bile acids (1 mg/0.5 ml per day, 5 days/week) for 4 weeks. The mean numbers of ACF per colon in ...

journal_title：Cancer letters

authors： Lin CX,Umemoto A,Seraj MJ,Mimura S,Monden Y

更新日期：2001-08-28 00:00:00

abstract：:The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...

journal_title：Cancer letters

authors： Papadopoulos D,Seidegard J,Rydström J

更新日期：1984-02-01 00:00:00

abstract：:The incidence of breast cancer has increased rapidly in recent years and has now become the most common cancer in women in major cities of China. Here, we reviewed the history and progress of breast cancer research in China, including achievements that Chinese scientists have made in basic, translational and clinical ...

journal_title：Cancer letters

authors： Hong W,Dong E

更新日期：2014-08-28 00:00:00

abstract：:The p53 mutations in betel-related oral cancer have been studied but the results may be confounded by tobacco and alcohol due to tobacco components in the quid or concomitant habits of smoking and drinking. In this study, p53 mutations in tumors from Thai betel chewers who neither smoke nor drink were studied in compa...

journal_title：Cancer letters

authors： Thongsuksai P,Boonyaphiphat P,Sriplung H,Sudhikaran W

更新日期：2003-11-10 00:00:00

abstract：:Green tea components exert many biological effects, including antitumor and cancer preventive activities. In the search for anticancer agents for prostate cancer the inhibitory effects of green tea components were tested on the prostate cancer cell lines LNCaP, PC-3 and DU145. (-)-Epigallocatechin-3-gallate (EGCG) pro...

journal_title：Cancer letters

authors： Paschka AG,Butler R,Young CY

更新日期：1998-08-14 00:00:00

abstract：:To investigate the monoclonality of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) and the origin of multiple lesions, patterns of inactivation of X-linked human androgen receptor gene were studied. Fourteen of 15 patients (93%) were heterozygous in the size of the target, and were informative for clonal an...

journal_title：Cancer letters

authors： Okuda T,Wakasa K,Kubo S,Hamada T,Fujita M,Enomoto T,Haba T,Hirohashi K,Kinoshita H

更新日期：2001-03-10 00:00:00

abstract：:Calcium-stimulated, phospholipid dependent protein kinase C activity was found in cytosolic extracts of the epidermis of SENCAR, C57BL/6 and Ha/ICR mice. The enzymes were partially purified by DEAE-cellulose chromatography. There were no significant differences between the 3 strains in basal protein kinase C activity....

journal_title：Cancer letters

authors： Garte SJ,Edinger F,Mufson RA

更新日期：1985-11-01 00:00:00

abstract：AIM:the ability of the breast cancer-associated placental acid isoform of ferritin (p43-PLF) to modulate cell surface expression of HLA, CD59 (protectin) and CD66 antigen (adhesion antigen related to CEA) was examined. METHODS:the expression of these antigens in human breast carcinoma cell lines BT-20, T47D and MDA-MB...

journal_title：Cancer letters

authors： Sedlak J,Reinerova M,Hunakova L,Ausch C,Chorvath B,Rosen H,Moroz C

更新日期：1995-07-20 00:00:00

abstract：:Activation of the cytoplasmic (Ras-Raf-MEK-ERK) signaling cascade was shown to be both, necessary and sufficient for transformation in vitro as well as in vivo. However, over the last years the involvement of stress-activated protein kinases (SAPKs)/Jun N-terminal kinases (JNKs), and their substrate c-Jun in the proce...

journal_title：Cancer letters

authors： Rennefahrt U,Illert B,Greiner A,Rapp UR,Troppmair J

更新日期：2004-11-08 00:00:00

abstract：:The promoting potential of oxymetholone (OXM) administration on development of liver cell foci was investigated in male F344 rats previously treated with N-diethylnitrosamine (DEN). One week after a single injection of DEN (100 mg/kg, i.p.), rats were given OXM at a dietary level of 0.2% for the first 4 weeks and then...

journal_title：Cancer letters

authors： Shimoji N,Imaida K,Hasegawa R,Matsuoka C,Uneyama CT,Takahashi M,Hayashi Y

更新日期：1990-02-01 00:00:00

abstract：:Immunometabolism, which has important implications in cancer biology, has emerged as a major regulator of different immune cell types. Various factors that integrate metabolic switches within immune cells with signal directed program that promote or inhibit their functions remain largely unidentified. Furthermore, sex...

journal_title：Cancer letters

authors： Zi Xu YX,Ande SR,Mishra S

更新日期：2018-02-28 00:00:00

abstract：:Epigenetic disruption of tumor suppressor genes (TSGs), particularly DNA methylation, plays a key role in hepatocellular carcinoma (HCC) pathogenesis. Through methylome study, we identified BCLB as a methylated gene in HCC. BCLB was methylated in all tumor cell lines with silenced or reduced expression. BCLB was furth...

journal_title：Cancer letters

authors： Liu X,Hu X,Kuang Y,Yan P,Li L,Li C,Tao Q,Cai X

更新日期：2017-06-01 00:00:00

abstract：:Human promyelocytic leukemia cells (HL-60) were found to be induced by dimethylsulfoxide and several other compounds to phagocytize, reduce NBT dye, and change into forms that were morphologically similar to granulocytes and macrophages. Arginase also induced these differentiation-associated properties of the cells. T...

journal_title：Cancer letters

authors： Honma Y,Fujita Y,Okabe-Kado J,Kasukabe T,Hozumi M

更新日期：1980-10-01 00:00:00

abstract：:Mice with hereditary intestinal polyposis have mutations of the APC gene which causes formation of multiple polyps. At least one other gene influences the susceptibility for development of polyps in mice, and the locus was named Mom1. The causative gene for the Mom1 locus has recently been cloned and was found to be i...

journal_title：Cancer letters

authors： Kawamata N,Seriu T,Bartram CR,Koeffler HP

更新日期：1997-01-01 00:00:00

abstract：:Conventional chemotherapies have some limitations, including the lack of selectivity, high toxicity to normal tissues, multidrug resistance, and tumor relapse. Recently, great progress was made in immunotherapies for anticancer research, with bacteria-mediated cancer therapy one of the most promising approaches among ...

journal_title：Cancer letters

authors： Guo Y,Chen Y,Liu X,Min JJ,Tan W,Zheng JH

更新日期：2020-01-28 00:00:00

abstract：:Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Thus, in the current study, the ability of LIM and other monoterpe...

journal_title：Cancer letters

authors： Morse MA,Toburen AL

更新日期：1996-07-12 00:00:00

abstract：:Inheritance of certain polymorphic metabolizing genes is associated with the development of a number of environmental cancers and may also influence the clinicopathological tumor outcome. We have investigated the association between the inheritance of the polymorphic cytochrome P-450 2D6 (CYP2D6) gene and the developm...

journal_title：Cancer letters

authors： Abdel-Rahman SZ,Anwar WA,Abdel-Aal WE,Ghoneim MA,Au WW

更新日期：1997-10-28 00:00:00

abstract：:Our previous studies demonstrated that dietary garlic powder supplementation inhibits N-nitrosamine induced DNA alkylation in liver and mammary tissue. The present studies compared the impact of dietary supplementation with garlic powder or two garlic constituents, water-soluble S-allyl cysteine (SAC) and oil-soluble ...

journal_title：Cancer letters

authors： Schaffer EM,Liu JZ,Green J,Dangler CA,Milner JA

更新日期：1996-04-19 00:00:00

abstract：:Hepatitis C virus Core plays a vital role in the development of hepatocellular carcinoma; however, its action mechanism is still controversial. Here, we showed that Core down-regulated levels of p16, resulting in inactivation of Rb and subsequent activation of E2F1, which lead to growth stimulation of hepatocytes. For...

journal_title：Cancer letters

authors： Park SH,Lim JS,Lim SY,Tiwari I,Jang KL

更新日期：2011-11-01 00:00:00

abstract：:Citral inhibits the formation of retinoic acid from retinol in mouse epidermis. Since skin-carcinogenesis is sensitive to retinoid status, and retinoic acid may be the active form of vitamin A in the epidermis, citral was tested for its ability to modulate tumor promotion in a two-stage skin-carcinogenesis study in ha...

journal_title：Cancer letters

authors： Connor MJ

更新日期：1991-01-01 00:00:00

abstract：:Interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF) facilitate the maturation and functioning of injected DC. We developed a method of in situ electroporation using IL-2 and GM-CSF genes (EGT/cytokines), followed by intra-tumoral (i.t.) immature DC to determine the immune response at the...

journal_title：Cancer letters

authors： Wang YS,Tsang YW,Chi CH,Chang CC,Chu RM,Chi KH

更新日期：2008-08-08 00:00:00

abstract：:The 825C>T polymorphism in the gene for the G-protein beta3 subunit (GNB3) has been linked to the occurrence of a splice variant of GNB3 and distinct cellular and metabolic features and may be associated with malignant disease. 500 patients with histologically confirmed breast cancer and 500 female age-matched healthy...

journal_title：Cancer letters

authors： Krippl P,Langsenlehner U,Renner W,Yazdani-Biuki B,Wolf G,Wascher TC,Paulweber B,Samonigg H

更新日期：2004-03-31 00:00:00

abstract：:Human hepatoma Hep 3B cells underwent apoptosis in response to 100 microM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells, exhibited cond...

journal_title：Cancer letters

authors： Kim DG,Jo BH,You KR,Ahn DS

更新日期：1996-10-01 00:00:00

abstract：:Solid tumors are composed of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and immune cells. We here reveal a new mechanism by which tumor exposed-LEC (teLEC) exert mitogenic effects on tumor...

journal_title：Cancer letters

authors： Van de Velde M,Ebroin M,Durré T,Joiret M,Gillot L,Blacher S,Geris L,Kridelka F,Noel A

更新日期：2021-01-28 00:00:00

abstract：:To investigate mucin expression in breast cancer, immunohistochemical staining was performed on 30 mucinous carcinomas and 95 non-mucinous invasive carcinomas. MUC2 expression was detected in all mucinous carcinomas, but only in 11.1% of invasive ductal carcinomas, and in none of the invasive lobular carcinomas and me...

journal_title：Cancer letters

authors： Chu JS,Chang KJ

更新日期：1999-07-19 00:00:00

abstract：:In view of the controversy that exists regarding the histamine content and diamine oxidase activity in relation to human carcinomatous growths, the present investigation was undertaken and carcinomatous tissues of skin, breast and rectum were analysed. The result of the experiment gives a clear evidence that both hist...

journal_title：Cancer letters

authors： Chanda R,Ganguly AK

更新日期：1987-02-01 00:00:00