Abstract:
:TRIOBP isoforms 4 and 5 (TRIOBP-4/-5) are an actin-bundling protein associated with hearing loss. Here, we showed that TRIOBP-4/-5 was up-regulated in human pancreatic carcinoma cells. Knockdown of TRIOBP-4/-5 led to a loss of filopodia and a decrease in cell motility. Confocal microscopy showed that re-expression of GFP-TRIOBP-4 or -5 restored the filopodial formation in TRIOBP-4/-5-deficient PANC-1 cells. Finally, TRIOBP-4/-5 was shown to be overexpressed in human pancreatic cancer tissues. These results demonstrate a novel role of TRIOBP-4/-5 that promotes the motility of pancreatic cancer cells via regulating actin cytoskeleton reorganization in the filopodia of the cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Bao J,Wang S,Gunther LK,Kitajiri S,Li C,Sakamoto Tdoi
10.1016/j.canlet.2014.08.005subject
Has Abstractpub_date
2015-01-28 00:00:00pages
367-73issue
2 Pt Beissn
0304-3835issn
1872-7980pii
S0304-3835(14)00433-9journal_volume
356pub_type
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