Abstract：
:Flue gas condensate from briquet-fired residential furnaces was separated into a polycyclic aromatic compound (PAC)-free and a PAC-containing part, followed by a subfractionation of the PAC-containing fraction into 3 parts: PAC consisting predominantly of (a) 2 and 3 rings, (b) 4 and 5 rings and (c) 6 and more rings. To evaluate the carcinogenic potency of the condensate and its fractions, local application onto skin of mice in 2 or 3 doses was used. Since it was known from an earlier investigation that both the PAC-free fraction and the fraction containing PAC with 2 and 3 rings were almost ineffective, only PAC-fractions containing more than 3 rings were tested. The probit and Weibull analysis of the results showed that the condensate and the fractions containing PAC with 4 and 5 rings as well as 6 and more rings provoke local tumors after repeated application to the dorsal skin of mice. The tumor incidence exhibited a clear cut dose-response relationship. Fractions (b) and (c) were almost equally active, each contributing by about 50% to the total carcinogenicity. The content of benzo[a]pyrene (0.72 mg/g condensate) contributed by 10-11% to the total carcinogenicity of the emission.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Grimmer G,Brune H,Deutsch-Wenzel R,Dettbarn G,Misfeld J,Abel U,Timm Jdoi
10.1016/0304-3835(85)90076-xsubject
Has Abstractpub_date
1985-09-15 00:00:00pages
203-11issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(85)90076-Xjournal_volume
28pub_type
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