The role of membrane transporters in drug delivery to brain tumors.

Abstract:

:Most brain tumors are highly resistant to chemotherapy because many chemotherapeutic drugs poorly cross the blood-brain barrier, the blood-cerebrospinal-fluid barrier, and the plasma membrane of the tumor cells. This restricted drug delivery is largely due to the presence of integral plasma membrane proteins belonging to the solute carriers (SLCs) and to the ATP-binding cassette (ABC) superfamily of transporters that decisively determine substance uptake and efflux, respectively, by the barrier-forming cells and the tumor cells. This review focuses on the localization and function of drug-transporting members of both transporter groups in human brain.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Nies AT

doi

10.1016/j.canlet.2006.12.023

subject

Has Abstract

pub_date

2007-08-28 00:00:00

pages

11-29

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(06)00689-6

journal_volume

254

pub_type

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