Immune modulation by ER stress and inflammation in the tumor microenvironment.


:It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one of the central unsolved paradoxes of tumor immunology is how a tumor escapes immune control, which is reflected in the lack of effective autochthonous or vaccine-induced anti-tumor T cell responses. In this review, we discuss the role of the endoplasmic reticulum (ER) stress response/unfolded protein response (UPR) in the immunomodulation of myeloid cells and T cells. Specifically, we will discuss how the tumor cell UPR polarizes myeloid cells in a cell-extrinsic manner, and how in turn, thus polarized myeloid cells negatively affect T cell activation and clonal expansion.


Cancer Lett


Cancer letters


Rodvold JJ,Mahadevan NR,Zanetti M




Has Abstract


2016-09-28 00:00:00














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    pub_type: 杂志文章


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    journal_title:Cancer letters

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    authors: Kim JH,Yoon SY,Kim CN,Joo JH,Moon SK,Choe IS,Choe YK,Kim JW

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  • Restoration of natural killer cell cytotoxicity by VEGFR-3 inhibition in myelogenous leukemia.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lee JY,Park S,Min WS,Kim HJ

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Aqil F,Munagala R,Jeyabalan J,Agrawal AK,Kyakulaga AH,Wilcher SA,Gupta RC

    更新日期:2019-05-01 00:00:00

  • Low-frequency electromagnetic radiation enhances the induction of rat mammary tumors by nitrosomethyl urea.

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    journal_title:Cancer letters

    pub_type: 杂志文章


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  • Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ong RC,Lei J,Lee RK,Cheung JY,Fung KP,Lin C,Ho HP,Yu B,Li M,Kong SK

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  • Prediction models for platinum-based chemotherapy response and toxicity in advanced NSCLC patients.

    abstract::In this study, we aimed to establish a platinum-based chemotherapy response and toxicity prediction model in advanced non-small cell lung cancer (NSCLC) patients. 416 single nucleotide polymorphisms (SNPs) in 185 genes were genotyped, and their association with drug response and toxicity were estimated using logistic ...

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    pub_type: 杂志文章


    authors: Yin JY,Li X,Li XP,Xiao L,Zheng W,Chen J,Mao CX,Fang C,Cui JJ,Guo CX,Zhang W,Gao Y,Zhang CF,Chen ZH,Zhou H,Zhou HH,Liu ZQ

    更新日期:2016-07-10 00:00:00

  • Nelfinavir, an HIV protease inhibitor, induces apoptosis and cell cycle arrest in human cervical cancer cells via the ROS-dependent mitochondrial pathway.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Xiang T,Du L,Pham P,Zhu B,Jiang S

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  • Metabolism of the microregions of human breast cancer.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: dos Santos MA,Borges JB,de Almeida DC,Curi R

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  • Human hepatocellular carcinoma: expression profiles-based molecular interpretations and clinical applications.

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    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Hui KM

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  • Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells.

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    authors: Lee JH,Yoon JH,Yu SJ,Chung GE,Jung EU,Kim HY,Kim BH,Choi DH,Myung SJ,Kim YJ,Kim CY,Lee HS

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  • Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6.

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    authors: Van de Velde M,Ebroin M,Durré T,Joiret M,Gillot L,Blacher S,Geris L,Kridelka F,Noel A

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    journal_title:Cancer letters

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Tamura T,Shibutani M,Toyoda K,Shoda T,Takada K,Uneyama C,Takahashi M,Hirose M

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  • Failure of immunogenic tumors to elicit cytolytic T cells in syngeneic hosts.

    abstract::Immunogenic, methylcholanthrene-induced sarcomas failed to elicit the production of rapidly cytolytic T lymphocytes in syngeneic mice, although they did elicit the production of more slowly cytotoxic cells. They were, however, susceptible to attack by cytolytic T cells from allo-immune mice and, if infected with ectro...

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    pub_type: 杂志文章


    authors: Nelson DS,Hopper KE,Blanden RV,Gardner ID,Kearney R

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    pub_type: 杂志文章


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    authors: Rodríguez-Martínez Á,Torres-Durán M,Barros-Dios JM,Ruano-Ravina A

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  • NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.

    abstract::Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett's tumorigenesis. In this study, we investigated the role of NRF2 in response to exposure to acidic bile salts (ABS), in conditions that mimic GERD, using Barrett's esophagus cell models. We detected an increase in NRF2 protein levels, following...

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Quan C,Chen Y,Wang X,Yang D,Wang Q,Huang Y,Petersen RB,Liu X,Zheng L,Li Y,Huang K

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  • Differences in the migration capacity of primary human colon carcinoma cells (SW480) and their lymph node metastatic derivatives (SW620).

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    pub_type: 杂志文章


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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wong LM,Bern HA,Jones LA,Mills KT

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  • Tumoricidal bystander effect in the suicide gene therapy using mesenchymal stem cells does not injure normal brain tissues.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Amano S,Gu C,Koizumi S,Tokuyama T,Namba H

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Moon DO,Kim MO,Lee JD,Kim GY

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    abstract::As the frequent emergency of resistant tumor cells during treatment, the development of new agents with new modes of action attracts a great deal of interest. Polybia-MPI was a short cationic alpha-helical amphiphilic peptide that has selective toxicity toward cancer cells but no hemolytic activity. Its target selecti...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang KR,Yan JX,Zhang BZ,Song JJ,Jia PF,Wang R

    更新日期:2009-06-08 00:00:00

  • Restoration of IRF1-dependent anticancer effects by MEK inhibition in human cancer cells.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: AbuSara N,Razavi S,Derwish L,Komatsu Y,Licursi M,Hirasawa K

    更新日期:2015-02-28 00:00:00

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Osaki T,Takagi S,Hoshino Y,Okumura M,Fujinaga T

    更新日期:2006-11-18 00:00:00

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nevo I,Sagi-Assif O,Meshel T,Ben-Baruch A,Jöhrer K,Greil R,Trejo LE,Kharenko O,Feinmesser M,Yron I,Witz IP

    更新日期:2009-01-08 00:00:00

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Khar A,Varalakshmi C,Pardhasaradhi BV,Ali AM

    更新日期:1992-06-15 00:00:00

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Gauci CL,Wrathmell A,Alexander P

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