Immune modulation by ER stress and inflammation in the tumor microenvironment.

Abstract:

:It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one of the central unsolved paradoxes of tumor immunology is how a tumor escapes immune control, which is reflected in the lack of effective autochthonous or vaccine-induced anti-tumor T cell responses. In this review, we discuss the role of the endoplasmic reticulum (ER) stress response/unfolded protein response (UPR) in the immunomodulation of myeloid cells and T cells. Specifically, we will discuss how the tumor cell UPR polarizes myeloid cells in a cell-extrinsic manner, and how in turn, thus polarized myeloid cells negatively affect T cell activation and clonal expansion.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Rodvold JJ,Mahadevan NR,Zanetti M

doi

10.1016/j.canlet.2015.09.009

subject

Has Abstract

pub_date

2016-09-28 00:00:00

pages

227-36

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(15)00589-3

journal_volume

380

pub_type

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