当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma.

MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma.

Abstract：

:The chimeric transcripts described in endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6. The MEAF6/PHF1 fusion had hitherto been identified in only one tumor. We present two more ESS with MEAF6/PHF1 detected by transcriptome sequencing (case 1) and RT-PCR (case 2), proving that this fusion is recurrent in ESS. The transcript of both cases was an in-frame fusion between exon 5 of MEAF6 and exon 2 of PHF1. Both genes are involved in epigenetic modification, and this may well be their main pathogenetic theme also in ESS tumorigenesis.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Micci F,Gorunova L,Gatius S,Matias-Guiu X,Davidson B,Heim S,Panagopoulos I

doi

10.1016/j.canlet.2014.01.030

subject

Has Abstract

pub_date

2014-05-28 00:00:00

pages

75-8

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(14)00068-8

journal_volume

347

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initiation phase.

    abstract：:The chemopreventive influence of phenethyl isothiocyanate (PEITC) during the post-initiation stage was investigated in the N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamster tumorigenesis model. A total of 120 female 5-week-old hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 ham...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00089-0

    authors： Nishikawa A,Furukawa F,Kasahara K,Tanakamaru Z,Miyauchi M,Nakamura H,Ikeda T,Imazawa T,Hirose M

    更新日期：1999-07-01 00:00:00

  • Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents.

    abstract：:Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA-DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indicated that AA signif...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.02.021

    authors： Cheng CL,Chen KJ,Shih PH,Lu LY,Hung CF,Lin WC,Yesong Gu J

    更新日期：2006-02-08 00:00:00

  • Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer.

    abstract：:Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma and some other solid tumors. However, the direct functional mechanisms of tumor lethality mediated by apatinib have not yet been fully characterized, and the precise mechanis...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.05.046

    authors： Cheng X,Feng H,Wu H,Jin Z,Shen X,Kuang J,Huo Z,Chen X,Gao H,Ye F,Ji X,Jing X,Zhang Y,Zhang T,Qiu W,Zhao R

    更新日期：2018-09-01 00:00:00

  • Effect of alcohol consumption, cigarette smoking and flushing response on esophageal cancer risk: a population-based cohort study (JPHC study).

    abstract：:We examined the effect of alcohol consumption, cigarette smoking and flushing response on esophageal squamous cell carcinoma (ESCC) in a large-scale population-based cohort study. 44,970 middle-aged and older Japanese men were followed. A total of 215 cases of ESCC were newly diagnosed. Alcohol consumption and cigaret...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.10.020

    authors： Ishiguro S,Sasazuki S,Inoue M,Kurahashi N,Iwasaki M,Tsugane S,JPHC Study Group.

    更新日期：2009-03-18 00:00:00

  • Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines.

    abstract：:FOY-305 is a synthetic serine protease inhibitor and ONO-3403 and FO-349 are its derivatives. The effects of these compounds on the proliferation of 13 human neuroblastoma cell lines were investigated in vitro by MTT colorimetric assay. The half maximum inhibition concentrations of ONO-3403 varied between 22 and 90 mi...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00015-9

    authors： Hiwasa T,Kondo K,Nakagawara A,Ohkoshi M

    更新日期：1998-04-24 00:00:00

  • Hyaluronan grafted lipid-based nanoparticles as RNAi carriers for cancer cells.

    abstract：:RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2012.08.024

    authors： Landesman-Milo D,Goldsmith M,Leviatan Ben-Arye S,Witenberg B,Brown E,Leibovitch S,Azriel S,Tabak S,Morad V,Peer D

    更新日期：2013-07-01 00:00:00

  • Targeted therapy for hepatocellular carcinoma: Challenges and opportunities.

    abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, which ranks as the sixth of cancer-related death. Despite the emergence of targeted therapy, advanced-stage HCC remains largely incurable due to low response rate and therapeutic resistance. In this review, we mainly focused on the current pro...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.114428

    authors： Chen S,Cao Q,Wen W,Wang H

    更新日期：2019-09-28 00:00:00

  • Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat.

    abstract：:In the presence of iron, dihydroartemisinin forms free radicals and causes cell death. Since most cancer cells have high rates of iron intake, dihydroartemisinin would have selective cytotoxic effect on cancer cells. The present experiment was designed to study the effect of dihydroartemisinin and ferrous sulfate on t...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：

    authors： Moore JC,Lai H,Li JR,Ren RL,McDougall JA,Singh NP,Chou CK

    更新日期：1995-11-27 00:00:00

  • Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor.

    abstract：:To discover novel drugs for neuroblastoma treatment, we have previously screened a panel of drugs and identified 30 active agents against neuroblastoma cells. Here we performed microarray gene expression analysis to monitor the impact of these agents on a neuroblastoma cell line and used the connectivity map (cMAP) to...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2010.01.004

    authors： Gheeya J,Johansson P,Chen QR,Dexheimer T,Metaferia B,Song YK,Wei JS,He J,Pommier Y,Khan J

    更新日期：2010-07-01 00:00:00

  • Down-regulation of the human c-fos and c-myc proto-oncogene promoters by adeno-associated virus Rep78.

    abstract：:Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has anti-tumor and anti-proliferation properties in tissue culture and animal studies. Furthermore, AAV infection is negatively associated with human cervical cancer. C-myc has been implicated in cervical cancer, and c-fos is involved in signal tr...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90193-7

    authors： Hermonat PL

    更新日期：1994-06-30 00:00:00

  • CAMK2N1 suppresses hepatoma growth through inhibiting E2F1-mediated cell-cycle signaling.

    abstract：:Human kinome/phosphatome screen identified CAMK2N1 genes suppressing the development of human hepatocellular carcinoma (HCC). CAMK2N1 downregulation was found in 47% HCCs and associated with poor prognosis. The downregulation was mainly attributed to its genome deletion (28.4%) and DNA hypermethylation of its promoter...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.10.017

    authors： Peng JM,Tseng RH,Shih TC,Hsieh SY

    更新日期：2021-01-28 00:00:00

  • The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis.

    abstract：:Third generation bisphosphonates (BPs), including YM175 and YM529, are known to inhibit bone resorption. The aim of this study was to evaluate the anti-tumor effects of these drugs on murine osteosarcoma cell lines, in terms of proliferation and apoptosis. We found that both YM175 and YM529 strongly inhibited the in v...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.06.041

    authors： Horie N,Murata H,Nishigaki Y,Matsui T,Segawa H,Nogawa M,Yuasa T,Kimura S,Maekawa T,Fushiki S,Kubo T

    更新日期：2006-07-08 00:00:00

  • Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene.

    abstract：:The small 25 kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. The aim of the present review is to point ou...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2009.05.027

    authors： Bolignano D,Donato V,Lacquaniti A,Fazio MR,Bono C,Coppolino G,Buemi M

    更新日期：2010-02-01 00:00:00

  • Hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression in human ovarian carcinoma.

    abstract：:Hypoxia-inducible factor 1 alpha (HIF-1 alpha) that regulates genes involved in response to hypoxia and promotes neo-angiogenesis, is a transcriptional factor for vascular endothelial cell growth factor (VEGF). The aim of this study was to examine the expression of HIF-1 alpha and VEGF gene expressions and their relat...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00762-5

    authors： Nakayama K,Kanzaki A,Hata K,Katabuchi H,Okamura H,Miyazaki K,Fukumoto M,Takebayashi Y

    更新日期：2002-02-25 00:00:00

  • Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families.

    abstract：:Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present s...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.05.043

    authors： Frank B,Burwinkel B,Bermejo JL,Försti A,Hemminki K,Houlston R,Mangold E,Rahner N,Friedl W,Friedrichs N,Buettner R,Engel C,Loeffler M,Holinski-Feder E,Morak M,Keller G,Schackert HK,Krüger S,Goecke T,Moeslein G,Kloo

    更新日期：2008-11-18 00:00:00

  • Effect of later treatment with estrogen on reproductive tract lesions in neonatally estrogenized female mice.

    abstract：:Continuous ethinyl estradiol treatment following ovariectomy at day 38 of BALB/cfC3H mice treated neonatally with estradiol resulted in a more organized vaginal epithelium than that seen in the absence of postnatal estrogen, 30 days after treatment was initiated. Although the epithelium became increasingly disorganize...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90023-4

    authors： Wong LM,Bern HA,Jones LA,Mills KT

    更新日期：1982-11-01 00:00:00

  • Characterization of the gene expression profile of neuroblastoma cell line IMR-5 using serial analysis of gene expression.

    abstract：:The serial analysis of gene expression (SAGE) technique was used to generate a database of the most abundant transcripts of the MYCN-amplified neuroblastoma cell line IMR-5. A total of 8568 tags were sequenced and shown to represent 4034 unique tags, each of which corresponds to an individual transcript. Expression le...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00581-5

    authors： Fischer M,Berthold F

    更新日期：2003-02-10 00:00:00

  • P-glycoprotein expression by human colonic tumor cells influences the growth of tumor cells in vitro.

    abstract：:The stability of P-glycoprotein expression by high and low expressing cells obtained by flow sorting from two cell lines established from colonic tumors was assessed. Low expressing cells rapidly recovered expression to a level that was comparable to that determined for uncloned cells. High expressing cells maintained...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03838-n

    authors： Frommel TO

    更新日期：1995-08-01 00:00:00

  • Oncogenic HBV variants and integration are present in hepatic and lymphoid cells derived from chronic HBV patients.

    abstract：:The hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC), partly driven by viral integration and specific oncogenic HBV variants. However, the biological significance of HBV genomes within lymphoid cells (i.e., peripheral blood mononuclear cells, PBMCs) is unclear. Here, we collected available pl...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.03.022

    authors： Lau KC,Joshi SS,Gao S,Giles E,Swidinsky K,van Marle G,Bathe OF,Urbanski SJ,Terrault NA,Burak KW,Osiowy C,Coffin CS

    更新日期：2020-06-28 00:00:00

  • Prevention of spontaneous and chemically induced carcinogenesis using activated carbon fiber adsorbent. III. Inhibitory effect of the activated carbon fiber adsorbent 'Aqualen' on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats.

    abstract：:Two-month-old outbred female LIO rats were exposed weekly to 15 (experiment I, groups 1, 2 and 3) or to 5 (experiment II, groups 4, 5 and 6) subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg of body weight. From the day of the first injection of the carcinogen, the rats from groups 2,...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00362-0

    authors： Anisimov VN,Zabezhinski MA,Popovich IG,Berstein LM,Kovalenko IG,Lieberman AI,Shmidt JL

    更新日期：1999-04-26 00:00:00

  • Pancreatic carcinogenicity of N-nitrosobis(2-oxopropyl)-amine in diabetic and non-diabetic Chinese hamsters.

    abstract：:To examine the role of diabetes in pancreatic cancer, 4 groups of Chinese hamsters--2 from genetically diabetic and 2 from non-diabetic lines--were treated with N-nitrosobis(2-oxo-propyl)amine (BOP) at different dose levels and intervals. In one group (referred to as the VA group), BOP was given weekly at a 5 mg/kg bo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(87)90014-0

    authors： Bell RH Jr,Pour PM

    更新日期：1987-02-01 00:00:00

  • The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins.

    abstract：:To clarify the roles of Bmi-1 in colorectal carcinoma, we examined the expression of Bmi-1 in 41 samples out of 46 colorectal carcinomas by reverse transcription-PCR, whereas all 46 were analyzed by immunostaining. In addition, we analyzed the expression patterns of Bmi-1 in association with p16INK4a and p14ARF (in mo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2003.07.009

    authors： Kim JH,Yoon SY,Kim CN,Joo JH,Moon SK,Choe IS,Choe YK,Kim JW

    更新日期：2004-01-20 00:00:00

  • HLA-A, B, C, DR and DQ expression and hepatocellular carcinoma: study of 205 Italian subjects.

    abstract：:We have evaluated the frequency of HLA class I and II antigens in 205 Italian patients with hepatocellular carcinoma (HCC) and 749 blood donors (controls). Moreover, we have looked for correlations between HLA antigen frequencies and HBV and/or HCV infections in HCC patients. We found great differences in HLA antigen ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：

    authors： Ricci G,Colombo C,Ghiazza B,Porta C,Moroni M,Illeni MT

    更新日期：1995-11-27 00:00:00

  • Epigenetic biomarkers in skin cancer.

    abstract：:Epigenetic aberrations have been associated with cutaneous melanoma tumorigenesis and progression including dysregulated DNA gene promoter region methylation, histone modification, and microRNA. Several of these major epigenetic aberrations have been developed into biomarkers. Epigenetic biomarkers can be detected in ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2012.01.020

    authors： Greenberg ES,Chong KK,Huynh KT,Tanaka R,Hoon DS

    更新日期：2014-01-28 00:00:00

  • On the formation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone during smoking.

    abstract：:Tobacco-specific N-nitrosamines (TSNA) are the most abundant carcinogens identified in tobacco and its smoke. Reducing their levels in tobacco products and especially in cigarette smoke is, therefore, a primary goal towards minimizing the carcinogenic burden of the tobacco consumer. This study delineates the mechanism...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90173-8

    authors： Adams JD,Lee SJ,Vinchkoski N,Castonguay A,Hoffmann D

    更新日期：1983-01-01 00:00:00

  • Harnessing immune checkpoints in myeloid lineage cells for cancer immunotherapy.

    abstract：:Myeloid lineage immune cells, such as macrophages and dendritic cells, play important roles in the induction of antitumor immunity during the initial stage of the cancer-immunity cycle, eliciting antitumor adaptive immunity by phagocytosing cancer cells and processing cancer-specific antigens, and then presenting thes...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.03.018

    authors： Park SY,Kim IS

    更新日期：2019-06-28 00:00:00

  • Arsenic trioxide-mediated Notch pathway inhibition depletes the cancer stem-like cell population in gliomas.

    abstract：:Cancer stem-like cells (CSLCs) are potential targets for treatment of glioblastoma multiforme (GBM) due to their role in tumorigenesis and recurrence. In this study, we investigated the inhibitory effect of arsenic trioxide (As(2)O(3)) on CSLCs of GBM in human glioma cell lines (U87MG, U251MG and U373MG) in vivo and i...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.11.005

    authors： Zhen Y,Zhao S,Li Q,Li Y,Kawamoto K

    更新日期：2010-06-01 00:00:00

  • Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases.

    abstract：:Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(96)04459-x

    authors： Cates CA,Michael RL,Stayrook KR,Harvey KA,Burke YD,Randall SK,Crowell PL,Crowell DN

    更新日期：1996-12-20 00:00:00

  • Delayed induction of ornithine decarboxylase in mouse skin after irradiation with beta-rays.

    abstract：:Irradiation with 90Sr-90Y beta rays induced ornithine decarboxylase (ODC) activity in mouse skin. Maximum activity appeared after about 17 days, at the time of appearance of skin injuries. These findings suggest the presence of tumor-promoting activity of beta rays. ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90070-2

    authors： Fujiki H,Mori M,Tanooka H

    更新日期：1982-01-01 00:00:00

  • Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ).

    abstract：:Synovial sarcoma is a relatively common soft tissue sarcoma with an aggressive clinical course. Although surgery is currently the first treatment modality, improvement of adjuvant chemotherapy is deemed essential to improve the clinical outcome. Nuclear factor-kappaB (NF-kappaB) is constitutively activated in various ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.07.021

    authors： Horiuchi K,Morioka H,Nishimoto K,Suzuki Y,Susa M,Nakayama R,Kawai A,Sonobe H,Takaishi H,Ozaki T,Yabe H,Umezawa K,Toyama Y

    更新日期：2008-12-18 00:00:00