当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Harnessing immune checkpoints in myeloid lineage cells for cancer immunotherapy.

Harnessing immune checkpoints in myeloid lineage cells for cancer immunotherapy.

Abstract：

:Myeloid lineage immune cells, such as macrophages and dendritic cells, play important roles in the induction of antitumor immunity during the initial stage of the cancer-immunity cycle, eliciting antitumor adaptive immunity by phagocytosing cancer cells and processing cancer-specific antigens, and then presenting these antigens to T cells. During this process, cancer cell phagocytosis can be prevented by inhibitory signals, and the signaling cascades that elicit immune responses against cancer antigens can be inhibited by immunosuppressive myeloid cells in the tumor microenvironment. A number of therapeutic strategies for enhancing cancer cell phagocytosis and promoting antitumor immunity by targeting myeloid lineage cells have recently been developed. Here, we discuss recent advances in cancer immunotherapy that involve the targeting of myeloid lineage immune cells to induce effective antitumor immunity.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Park SY,Kim IS

doi

10.1016/j.canlet.2019.03.018

subject

Has Abstract

pub_date

2019-06-28 00:00:00

pages

51-58

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(19)30174-0

journal_volume

452

pub_type

杂志文章,评审

相关文献

CANCER LETTERS文献大全
  • ETS1 induction by the microenvironment promotes ovarian cancer metastasis through focal adhesion kinase.

    abstract：:Metastatic colonization involves paracrine/juxtacrine interactions with the microenvironment inducing an adaptive response through transcriptional regulation. However, the identities of transcription factors (TFs) induced by the metastatic microenvironment in ovarian cancer (OC) and their mechanism of action is poorly...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.11.012

    authors： Tomar S,Plotnik JP,Haley J,Scantland J,Dasari S,Sheikh Z,Emerson R,Lenz D,Hollenhorst PC,Mitra AK

    更新日期：2018-02-01 00:00:00

  • Heterogeneity of liver cancer and personalized therapy.

    abstract：:Liver cancer is an extraordinarily heterogeneous malignant disease among the tumors that have so far been identified. Hepatocellular carcinoma (HCC) arises most frequently in the setting of chronic liver inflammation and fibrosis, and takes a variety of course in individual patients to process to tumor. The risk facto...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2015.07.018

    authors： Li L,Wang H

    更新日期：2016-09-01 00:00:00

  • Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene.

    abstract：:The small 25 kDa peptide, neutrophil gelatinase-associated lipocalin (NGAL), first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. The aim of the present review is to point ou...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2009.05.027

    authors： Bolignano D,Donato V,Lacquaniti A,Fazio MR,Bono C,Coppolino G,Buemi M

    更新日期：2010-02-01 00:00:00

  • MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53.

    abstract：:The overexpression of the MDM2 oncoprotein frequently occurs in hepatocellular carcinoma (HCC). Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type HCC, but most patients have p53-mutant tumors and intrinsic resistance to such MDM2 inhibitors. We have recently discovered that the NFAT1 tr...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.114429

    authors： Wang W,Cheng JW,Qin JJ,Hu B,Li X,Nijampatnam B,Velu SE,Fan J,Yang XR,Zhang R

    更新日期：2019-09-10 00:00:00

  • Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models.

    abstract：:A panel of clinically used tyrosine kinase inhibitors were compared and nilotinib was found to most potently sensitize specific anticancer agents by blocking the functions of ABCB1/P-glycoprotein, ABCG2/BCRP and ABCC10/MRP7 transporters involved in multi-drug resistance. Nilotinib appreciably enhanced the antitumor re...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2012.10.001

    authors： Tiwari AK,Sodani K,Dai CL,Abuznait AH,Singh S,Xiao ZJ,Patel A,Talele TT,Fu L,Kaddoumi A,Gallo JM,Chen ZS

    更新日期：2013-01-28 00:00:00

  • Reversal of drug resistance in breast carcinoma cells by anti-mdr1 ribozyme regulated by the tumor-specific MUC-1 promoter.

    abstract：:Multidrug resistance (MDR) is a serious obstacle for cancer chemotherapy. The aim of this study was to reverse MDR of breast carcinoma cells specifically by degrading mdr1 mRNA with anti-mdr1 ribozyme. Our strategy was to limit the expression of ribozyme to only breast-derived cells, but not other type of cells. The r...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.06.005

    authors： Gao P,Zhou GY,Guo LL,Zhang QH,Zhen JH,Fang AJ,Lin XY

    更新日期：2007-10-18 00:00:00

  • Dietary ortho phenols that induce glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms: the alleviation of oxidative stress and the detoxification of mutagenic

    abstract：:Oxidative stress is implicated in the etiology of cancer, hence compounds that alleviate oxidative stress by inducing enzymes that defend against free radical damage might be useful as cancer chemopreventives. Glutathione S-transferase (GST) has been suggested to be a candidate for a critical enzyme in protecting cell...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00368-2

    authors： Fiander H,Schneider H

    更新日期：2000-08-11 00:00:00

  • Mistletoe lectins I, II and III induce the production of cytokines by cultured human monocytes.

    abstract：:The three mistletoe (Viscum album L.) lectins. ML I, ML II and ML III, were tested on their ability to enhance the secretion of the cytokines tumor necrosis factor (TNF)alpha, interleukin (IL)-1 alpha, IL-1 beta and IL-6 by human monocytes obtained from healthy donors. At lectin concentrations from 0.02 to 20/pg ml (1...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(96)04401-1

    authors： Ribéreau-Gayon G,Dumont S,Muller C,Jung ML,Poindron P,Anton R

    更新日期：1996-12-03 00:00:00

  • Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat.

    abstract：:Lactoferrin, an iron-binding glycoprotein, exhibits suppressive effects on development of azoxymethane (AOM)-induced tumors in the rat colon, but the mechanisms are largely unknown. In this study, we investigated the effect of lactoferrin on the gene expression of 10 apoptosis-related molecules in colon mucosa of AOM-...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.03.029

    authors： Fujita K,Matsuda E,Sekine K,Iigo M,Tsuda H

    更新日期：2004-09-15 00:00:00

  • Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat.

    abstract：:Artemisinin, a compound isolated from the sweet wormwood Artemisia annua L., has previously been shown to have selective toxicity towards cancer cells in vitro. In the present experiment, we studied the potential of artemisinin to prevent breast cancer development in rats treated with a single oral dose (50mg/kg) of 7...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.01.019

    authors： Lai H,Singh NP

    更新日期：2006-01-08 00:00:00

  • Comparison of the antiproliferative effects of transforming growth factor-beta, N,N-dimethylformamide and retinoic acid on a human colon carcinoma cell line.

    abstract：:In this study we have compared the anti-proliferative effects of transforming growth factor-beta (TGF-beta), N,N-dimethylformamide (DMF) and retinoic acid (RA) on a moderately-differentiated colon carcinoma cell line (JVC). TGF-beta, DMF and RA inhibited the anchorage-independent growth and induced morphological chang...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90014-6

    authors： Hoosein NM,Brattain DE,McKnight MK,Childress KE,Chakrabarty S,Brattain MG

    更新日期：1988-06-15 00:00:00

  • Combined effects of 13-cis-retinoic acid, tamoxifen and interferon on the growth of human breast cancer cells.

    abstract：:We studied the effect of 13-cis-retinoic acid (13-cRA) alone and in combination with interferons (IFNs) and tamoxifen (TAM) in two established human breast cancer cell lines: the estrogen-sensitive CG-5 and the estrogen-insensitive MDA-MB-453 cells. 13-cRA (10(-9)-10(-5) M) significantly reduced the growth of both cel...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)04099-4

    authors： Lama G,Angelucci C,Recchia F,Sica G

    更新日期：1996-02-27 00:00:00

  • Regulation of death promoter Bak expression by cell density and 17 beta-estradiol in MCF-7 cells.

    abstract：:In the current study we examined the regulation of Bak, a death promoter of an apoptotic pathway, in the human breast cancer cell line MCF-7. We observed a time-dependent increase in both Bak mRNA and protein levels which appeared to correlate well with the increase in cell density. We also found that treatment of cel...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00430-8

    authors： Leung LK,Do L,Wang TT

    更新日期：1998-02-13 00:00:00

  • Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.

    abstract：:Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. AMP-activated protein kinase (AMPK) is activated after cetuximab treatment, and a sustained AMPK activity is a mechanism contributing to cetuximab resistance. Here, w...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.09.020

    authors： Luo J,Hong Y,Lu Y,Qiu S,Chaganty BK,Zhang L,Wang X,Li Q,Fan Z

    更新日期：2017-01-01 00:00:00

  • Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma.

    abstract：:Epidermal growth factor receptor (EGFR) is highly expressed in many human tumors including hepatocellular carcinoma (HCC). Therefore, inhibition of EGF receptors could be a potential target for anticancer therapy. In this study, we investigated the effects of two EGFR tyrosine kinase inhibitors, PD153035 and its analo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2006.05.018

    authors： Liu Y,Poon RT,Shao W,Sun X,Chen H,Kok TW,Fan ST

    更新日期：2007-04-08 00:00:00

  • Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats.

    abstract：:The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a lung carcinogen in the rat and believed to be a causative agent for lung cancer in smokers. To exert its carcinogenic potential NNK is metabolically activated by cytochrome P450-catalyzed alpha-hydroxylation. Nicotine and NNK s...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2003.07.004

    authors： Keyler D,Pentel PR,Kuehl G,Collins G,Murphy SE

    更新日期：2003-12-08 00:00:00

  • Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer.

    abstract：:Absent or altered differentiation is one of the major features of cancer cells. Histone deacetylases (HDACs) play a central role in the epigenetic regulation of gene expression. Aberrant activity of HDACs has been documented in several types of cancers, leading to the development of HDAC inhibitors (HDACi) as anti-tum...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2009.02.027

    authors： Botrugno OA,Santoro F,Minucci S

    更新日期：2009-08-08 00:00:00

  • ARID1A deficiency and immune checkpoint blockade therapy: From mechanisms to clinical application.

    abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2020.01.001

    authors： Hu G,Tu W,Yang L,Peng G,Yang L

    更新日期：2020-03-31 00:00:00

  • Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: Implications for cellular proteolysis and adhesion in cancer.

    abstract：:Up-regulation of the urokinase plasminogen activation (uPA) system leads to increased cancer invasion and metastasis. Plasminogen activator inhibitors type-1 (PAI-1/SERPINE1) and type-2 (PAI-2/SERPINB2) have similar uPA inhibitory properties yet PAI-1 promotes cell invasion by modulating cell adhesion and migration. H...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.01.018

    authors： Lobov S,Ranson M

    更新日期：2011-04-28 00:00:00

  • Improvement of idarubicin induced antitumor activity and bone marrow suppression by theanine, a component of tea.

    abstract：:We have examined the effect of theanine, a specific amino acid in green tea, on idarubicin (IDA)-induced antitumor activity and toxicity. In combination with theanine, IDA (0.25 mg/kg per day x4 days, a dose that does not show antitumor activity) had significant antitumor activity in P388-bearing mice. The IDA concent...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00491-2

    authors： Sadzuka Y,Sugiyama T,Sonobe T

    更新日期：2000-10-01 00:00:00

  • Relation of transmembrane potential to cell survival following hyperthermia in HeLa cells.

    abstract：:Hyperthermia induces cell death and the usual endpoint to study this is the ability of the cells to form colonies. Hyperthermia is also known to alter membrane characteristics, especially transmembrane potential and this has been correlated with duration and degree of heating. The aim of the present study was to see t...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00185-8

    authors： Remani P,Ostapenko VV,Akagi K,Bhattathiri VN,Nair MK,Tanaka Y

    更新日期：1999-10-01 00:00:00

  • Point mutations at codon 12 of C-K-ras in human endometrial carcinomas.

    abstract：:Samples of human endometrial carcinomas of ranging degree of histological differentiation, and normal endometrial tissues were screened for the presence of single site DNA mutations at codon 12 of the C-K-ras gene using oligonucleotide hybridisation of DNA amplified by the polymerase chain reaction (PCR). Two instance...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(90)90223-k

    authors： Lester DR,Cauchi MN

    更新日期：1990-05-15 00:00:00

  • Frequent allelic loss on chromosomes 4q and 16q associated with human hepatocellular carcinoma in Taiwan.

    abstract：:To define the critical region of liver-specific tumor suppressor genes in human hepatocellular carcinoma (HCC), we analyzed 30 cases of hepatocellular carcinoma using nine 4q and six 16q microsatellite polymorphic DNA markers. We observed one major common deleted region which was flanked by D4S175-D4S1625 and there ma...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00276-0

    authors： Chou YH,Chung KC,Jeng LB,Chen TC,Liaw YF

    更新日期：1998-01-16 00:00:00

  • Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas.

    abstract：:cIAP-1, an apoptosis inhibiting protein, has been suggested to play important roles in the development of cervical and esophageal squamous cell carcinomas (SCCs). In order to clarify the subcellular localization of cIAP-1 and to investigate its clinicopathological significance in head and neck SCCs (HNSCCs), we examin...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.11.049

    authors： Tanimoto T,Tsuda H,Imazeki N,Ohno Y,Imoto I,Inazawa J,Matsubara O

    更新日期：2005-06-16 00:00:00

  • Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies.

    abstract：:Cancer results from the interaction of multiple aberrations including activation of dominant oncogenes and upregulation of signal transduction pathways. Identification of the genes involved in malignant transformation is a pre-requisite for understanding cancer and improving its diagnosis and treatment. Quite a few of...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2007.04.015

    authors： Katzav S

    更新日期：2007-10-08 00:00:00

  • Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages.

    abstract：:Inadequate immunity that occurs in a tumor environment is in part due to the presence of M2-type tumor-associated macrophages (TAMs). TGF-β has a multi-functional role in tumor development including modulating the biological activity of both the tumor and TAMs. In this study, using an in vitro TAM/tumor cell co-cultur...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.01.001

    authors： Peng J,Tsang JY,Li D,Niu N,Ho DH,Lau KF,Lui VC,Lamb JR,Chen Y,Tam PK

    更新日期：2013-05-01 00:00:00

  • The role of membrane transporters in drug delivery to brain tumors.

    abstract：:Most brain tumors are highly resistant to chemotherapy because many chemotherapeutic drugs poorly cross the blood-brain barrier, the blood-cerebrospinal-fluid barrier, and the plasma membrane of the tumor cells. This restricted drug delivery is largely due to the presence of integral plasma membrane proteins belonging...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2006.12.023

    authors： Nies AT

    更新日期：2007-08-28 00:00:00

  • Activation of complement system in adult T-cell leukemia (ATL) occurs mainly through lectin pathway: a serum proteomic approach using mass spectrometry.

    abstract：:Adult T-cell leukemia (ATL) is a fatal malignancy caused by infection with human T lymphotropic virus type-1 (HTLV-1). To search for a new biomarker of ATL, we analyzed sera from ATL patients using ProteinChip arrays. The spectral comparison of ATL patients with HTLV-1 carriers and healthy volunteers showed that the i...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.06.004

    authors： Ishida Y,Yamashita K,Sasaki H,Takajou I,Kubuki Y,Morishita K,Tsubouchi H,Okayama A

    更新日期：2008-11-18 00:00:00

  • The metabolic activation of dibenzo[a,e]fluoranthene in vitro. Evidence that its bay-region and pseudo-bay-region diol-epoxides react preferentially with guanosine.

    abstract：:Dibenzo[a,e]fluoranthene ( DBF ), a non- alternant carcinogenic polycyclic aromatic hydrocarbon (PAH), binds covalently to DNA. The main adducts were characterized as covalent additions of its bay-region and pseudo-bay-region diol-epoxides. The structure of these 2 adducts was analyzed by mass spectrometry using their...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(84)90165-4

    authors： Perin-Roussel O,Croisy A,Ekert B,Zajdela F

    更新日期：1984-04-01 00:00:00

  • Potent antitumor activity of zoledronic acid-induced Vγ9Vδ2 T cells against primary effusion lymphoma.

    abstract：:Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced Vγ9Vδ2 T cells against PEL cells in vitro and in vivo. Vγ9Vδ2 T cells recognized end...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2012.12.021

    authors： Goto H,Matsuda K,Srikoon P,Kariya R,Hattori S,Taura M,Katano H,Okada S

    更新日期：2013-05-01 00:00:00