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Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models.

Abstract：

:A panel of clinically used tyrosine kinase inhibitors were compared and nilotinib was found to most potently sensitize specific anticancer agents by blocking the functions of ABCB1/P-glycoprotein, ABCG2/BCRP and ABCC10/MRP7 transporters involved in multi-drug resistance. Nilotinib appreciably enhanced the antitumor response of (1) paclitaxel in the ABCB1- and novel ABCC10-xenograft models, and (2) doxorubicin in a novel ABCG2-xenograft model. With no apparent toxicity observed in the above models, nilotinib attenuated tumor growth synergistically and increased paclitaxel concentrations in ABCB1-overexpressing tumors. The beneficial actions of nilotinib warrant consideration as viable combinations in the clinic with agents that suffer from MDR-mediated insensitivity.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Tiwari AK,Sodani K,Dai CL,Abuznait AH,Singh S,Xiao ZJ,Patel A,Talele TT,Fu L,Kaddoumi A,Gallo JM,Chen ZS

doi

10.1016/j.canlet.2012.10.001

subject

Has Abstract

pub_date

2013-01-28 00:00:00

pages

307-17

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(12)00588-5

journal_volume

328

pub_type

杂志文章

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