Abstract:
:Data were obtained on soluble oestrogen (ER) and progesterone (PR) receptors from 273 primary breast tumours, using an enzyme immunoassay (EIA) and ligand binding assay with dextran-coated charcoal (DCC) or isoelectric focussing separations. The p29 and total cathepsin D content was also assayed in the same samples. Tumours expressing ER (by either steroid binding assay or EIA) had higher levels of p29 than those which did not express the receptor (P < 0.0001). Moreover, tumours co-expressing ER, PR and p29 appeared to have higher levels of cathepsin D than those which were negative for at least one protein (P < 0.0001). Twenty out of the 273 human breast cancer samples, containing a level of ER positive by EIA, which did not bind labelled oestradiol, were identified; isoelectric focussing showed that such a receptor was also unable to bind hydroxytamoxifen. These tumours did not significantly differ from those in the whole population in their capacity to express ER (positive by EIA), PR, p29 and cathepsin D. It was concluded that the EIA can detect both a ligand binding ER and a receptor which is able to initiate PR transcription but does not bind radio-labelled ligands in vitro; such a receptor could have a bearing on the variability of tumour response to endocrine therapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Marsigliante S,Greco S,Biscozzo L,Barker S,Baker V,Giuseppe L,Vinson GP,Storelli Cdoi
10.1016/0304-3835(92)90246-rkeywords:
subject
Has Abstractpub_date
1992-10-21 00:00:00pages
183-91issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(92)90246-Rjournal_volume
66pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::We have developed a monoclonal antibody (designated 1D7) which recognizes an M(r) 7-kDa plasma membrane protein overexpressed in ovarian MDR cancer cells. The expression of the M(r) 7-kDa protein in various human multidrug-resistant and drug-sensitive cell lines was analysed by Western blot and flow cytometry methods....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)03634-u
更新日期:1995-01-27 00:00:00
abstract:INTRODUCTION:Glioma initiating cells (GICs) play important roles in tumor initiation and progression. However, interactions between tumor cells and host cells of local tumor microenvironment are kept largely unknown. Besides GICs and their progeny cells, whether adjacent normal glial cells contribute to tumorigenesis d...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.05.026
更新日期:2015-09-01 00:00:00
abstract::All-trans retinoic acid (ATRA) inhibits proliferation of cancer. However, the effects of ATRA on scattering and invasion of pancreatic cancer cells remain unknown. Also, the effects of ATRA on c-Met expression in pancreatic cancer have never been addressed so far. The effects of ATRA on a pancreatic cancer cell line, ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.10.016
更新日期:2005-06-28 00:00:00
abstract::Breast cancer, especially triple-negative breast cancer (TNBC), has limited treatment options. We repurposed the FDA-approved drug bazedoxifene as a novel inhibitor of interleukin 6/glycoprotein 130 signaling. In this study, we investigated the inhibitory effects of bazedoxifene alone or in combination with paclitaxel...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.01.026
更新日期:2019-04-28 00:00:00
abstract::Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus. Groups of male rats were fed AIN-76A diet containing EA (4 g/kg), CRA (240 mg/kg), or a combination of EA and CRA (4 g/kg and 240 mg/...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90085-v
更新日期:1991-02-01 00:00:00
abstract::One of the most promising substances used in photodynamic therapy (PDT) is 5-aminolevulinic acid (ALA), which induces endogenous synthesis and accumulation of porphyrins in malignant cells. In this paper we have shown that both topical and intratumoral administration of ALA in a subcutaneously implanted mammary carcin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00079-8
更新日期:1999-07-01 00:00:00
abstract::Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04459-x
更新日期:1996-12-20 00:00:00
abstract::Rituximab is the first anti-cancer antibody approved by the FDA for the treatment of B-cell lymphoma. However, its efficacy remains variable and often modest. Some patients are initially unresponsive to rituximab or later develop resistance to it, and require alternative therapies. Rituximab activity has been thought ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.01.023
更新日期:2010-08-01 00:00:00
abstract::Suspensions of Walker and HeLa cells, rat fibroblasts and human stimulated lymphocytes were incubated over various periods with the synthetic amino steroid, 2 beta,16 beta-dipiperidino-5 alpha-androstane-3 alpha,17 beta-diol dipivalate (DAP). The acute cell destroying effect was found to be exponentially time and dose...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(77)80032-3
更新日期:1977-03-01 00:00:00
abstract::The effect of a purified, high protein diet on enhanced gastric carcinogenesis induced by oral administration of NaCl was investigated in Wistar rats. Rats were fed on a purified diet with an equalized caloric content, containing 8% NaCl and 25% casein (normal protein diet), or 50% casein (high protein diet) after ora...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00197-3
更新日期:1997-06-24 00:00:00
abstract::Rats bearing the Yoshida AH-130 ascites hepatoma, a cachectic rat tumour, showed signs of important muscle wasting with reduced muscle weights. This phenomenon was associated with a decreased rate of in vivo alanine oxidation as measured by the production of 14CO2 from [U-14C]alanine intragastrically administered. It ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90212-7
更新日期:1994-12-09 00:00:00
abstract::We reported that poor prognoses of hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA) are owing to up-regulation of expression of hypoxia-inducible factor-1 and epithelial cell adhesion molecule. We investigated aggressive progression in residual liver tumors (RLTs) after RFA to focus on expre...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.041
更新日期:2016-05-28 00:00:00
abstract::The incidence of pediatric cancers is rising steadily across the world, along with the challenges in understanding the molecular mechanisms and devising effective therapeutic strategies. Pediatric cancers are presented with diverse molecular characteristics and more distinct subtypes when compared to adult cancers. Re...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.11.015
更新日期:2021-02-28 00:00:00
abstract::Macrophage migration inhibitory factor (MIF) is up-regulated in diverse solid tumors and acts as the critical link between immune response and tumorigenesis. In this study, we demonstrated that MIF overexpression promoted migration of breast cancer cells by elevating TLR4 expression. Further investigation evidenced th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.005
更新日期:2016-06-01 00:00:00
abstract::Two-month-old outbred female LIO rats were exposed weekly to 15 (experiment I, groups 1, 2 and 3) or to 5 (experiment II, groups 4, 5 and 6) subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg of body weight. From the day of the first injection of the carcinogen, the rats from groups 2,...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00362-0
更新日期:1999-04-26 00:00:00
abstract::Deregulation of the cell-cycle G1-restriction point control via abnormalities of Rb-pathway components is a frequent event in the formation of cancer. The aim of this study was to evaluate numerical aberrations of the Cyclin D1 (CCND1, PRAD1, bcl-1) gene locus at chromosome 11q13 in basal cell carcinomas (BCCs) and sq...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.07.011
更新日期:2005-03-10 00:00:00
abstract::We have examined the effect of protease inhibitors on radiation-induced DNA amplification in vitro using an SV40-transformed Chinese hamster embryo cell line. DNA from cells irradiated with X-rays (10 Gy) or ultraviolet radiation (8 J/m2) resulted in an 8-fold or greater amplification of SV40 sequences compared with u...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90083-t
更新日期:1991-02-01 00:00:00
abstract::A variety of metal-binding compounds have been found to exert anti-cancer activity. We postulated that N-acetylcysteine (NAC), which is a membrane-permeable metal-binding compound, might have anti-cancer activity in the presence of metals. We found that NAC/Cu(II) significantly alters growth and induces apoptosis in h...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.07.003
更新日期:2010-12-08 00:00:00
abstract::Solid tumors are composed of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and immune cells. We here reveal a new mechanism by which tumor exposed-LEC (teLEC) exert mitogenic effects on tumor...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.10.020
更新日期:2021-01-28 00:00:00
abstract::In the present work we investigated the in vivo regulation of the mucin gene MUC2, which is overexpressed in all mucinous colorectal carcinomas. The inhibition of methylation by 5-azadeoxycytidine induces de novo expression of MUC2 in the colon carcinoma cell line COLO 205. The expression is retained in xenograft tiss...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00498-0
更新日期:2001-07-10 00:00:00
abstract::Enhanced c-erbB-2/neu expression has been linked with a poor prognosis in human bladder cancer. Previous reports have shown that a point mutation at nucleotide T2012 in the coding region of the transmembrane domain of the rat gene is sufficient to confer transformation potential on this gene. We examined the comparati...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90352-2
更新日期:1994-08-29 00:00:00
abstract::The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.01.026
更新日期:2009-06-28 00:00:00
abstract::Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larg...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90250-2
更新日期:1990-07-16 00:00:00
abstract::N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90053-1
更新日期:1980-10-01 00:00:00
abstract::The aim of the present study was to estimate the expression of mRNA, specific for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase), i.e. enzymes involved in pyrimidine and purine metabolism in human papillary thyroid carcinoma (PTC) tissue. Additionally, the expression of dC...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.10.044
更新日期:2005-07-28 00:00:00
abstract::Thrombospondin-1 is one of most important natural angiogenic inhibitors. The three thrombospondin-1 type 1 repeats (3TSR), an anti-angiogenic domain of thrombospondin-1, is a promising novel agent for anti-angiogenic treatment. In the present study, we showed 3TSR was biologically stable at least for 7 days in mini-os...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.04.003
更新日期:2007-03-08 00:00:00
abstract::An increase in the levels of oxidation is a universal feature of genomic DNA of irradiated or aged or even malignant cells. In case of apoptotic death of stressed cells, oxidized DNA can be released in circulation (cfDNA). According to the results of the studies performed in vitro by our group and other researchers, t...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.09.005
更新日期:2015-01-01 00:00:00
abstract::The limitations of current chemotherapies have motivated research in developing new treatments. Growing evidence shows that interaction between tumors and their microenvironment, but not tumor cells per se, is the key factor in tumor progression and therefore of obvious scientific interest and therapeutic value. Exoso...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.07.014
更新日期:2015-10-10 00:00:00
abstract::We have investigated the structure of the carbohydrate moiety of the precursors of the cathepsin B-like proteinase (PCBt). The largest precursor has an apparent molecular size (Mr) of 45-47 Kd and it contains 3 N-linked oligosaccharide chains which were Endo beta N acetylglucosaminidase H (Endo H)-resistant forms. On ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90030-x
更新日期:1989-04-01 00:00:00
abstract::The gut microbiota forms a symbiotic relationship with the host and benefits the body in many critical aspects of life. However, immune system defects, alterations in the gut microbiota and environmental changes can destroy this symbiotic relationship and may lead to diseases, including cancer. Due to the anatomic and...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2020.01.002
更新日期:2020-04-01 00:00:00