Abstract：
:Enhanced c-erbB-2/neu expression has been linked with a poor prognosis in human bladder cancer. Previous reports have shown that a point mutation at nucleotide T2012 in the coding region of the transmembrane domain of the rat gene is sufficient to confer transformation potential on this gene. We examined the comparative levels of p185neu as well as the sequence around the hotspot (T2012) of the neu gene of rat bladder cells transformed by 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) or established in culture from N-[-4-(-5-nitro-2-furyl)-2- thiazolyl]formamide (FANFT)-induced rat bladder tumors. We concluded that increased p185neu expression did not correlate significantly with tumorigenicity. No alterations in nucleotide sequences of the neu gene were observed in either in vitro model.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Mann AM,Asamoto M,Masui T,Macatee T,Eklund SH,Cohen SMdoi
10.1016/0304-3835(94)90352-2subject
Has Abstractpub_date
1994-08-29 00:00:00pages
7-13issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(94)90352-2journal_volume
84pub_type
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