Abstract:
:Transcriptional factor BTB and CNC homology 1 (Bach1) has been linked to tumor progression and metastasis, but the mechanisms underlying the effects of Bach1 on tumor growth and metastasis are largely uncharacterized. Here, we report that Bach1 expression was significantly higher in human epithelial ovarian cancer (EOC) tissues than in normal ovarian tissues and that higher levels of Bach1 were associated with tumor stage and poorer overall and progression-free survival. We found that Bach1 enhanced the expression of epithelial-mesenchymal transition (EMT) genes, including Slug and Snail, and promoted cell migration by recruiting HMGA2 in the human EOC cell line A2780. Bach1 overexpression enhanced and Bach1 knockout reduced the expression of Slug and the metastasis of EOC cells in a tumor metastasis mouse model. Bach1 expression was positively correlated with Slug and HMGA2 expression in human ovarian cancer tissues. In addition, Bach1 activated p-AKT and p-p70S6K, increased the expression of cyclin D1, and promoted the growth of ovarian cancer cells in vitro and tumor xenografts in vivo. Together, our findings reveal that Bach1 enhances tumor growth and recruits HMGA2 to promote EMT and ovarian cancer metastasis.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Han W,Zhang Y,Niu C,Guo J,Li J,Wei X,Jia M,Zhi X,Yao L,Meng Ddoi
10.1016/j.canlet.2019.01.003subject
Has Abstractpub_date
2019-03-31 00:00:00pages
45-56eissn
0304-3835issn
1872-7980pii
S0304-3835(19)30015-1journal_volume
445pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Mesenchymal stem cells (MSCs) are the first type of stem cells to be utilized in clinical regenerative medicine, mainly owing to their capacity for multipotent differentiation and the feasibility of autologous transplantation. More recently, the specific tumor-oriented migration and incorporation of MSCs have been dem...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2011.02.012
更新日期:2011-06-01 00:00:00
abstract::Alteration of the p16 tumor suppressor gene has been implicated as a critical lesion in the molecular pathogenesis of esophageal adenocarcinoma. The aim of this study was to characterize the spectrum of p16 alterations in surgically resected esophageal tissues, comprising histologically normal esophageal squamous and ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.06.025
更新日期:2005-01-20 00:00:00
abstract::The incidence of carcinomas highly increases with age. However, the initial steps of the age-related molecular carcinogenic processes remain poorly characterized. We previously showed that normal human epidermal keratinocytes spontaneously and systematically escape from senescence to give rise to preneoplastic emergin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.09.008
更新日期:2018-12-01 00:00:00
abstract::Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Great interest persists in useful therapeutic targets in GBM. Aberrant expression of long non-coding RNAs (lncRNAs) has been functionally associated with many cancers. Here, we elucidated the function and the possible molecular mechanisms of lnc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.12.051
更新日期:2015-04-01 00:00:00
abstract::We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine. With both IFN-alpha and 5-FU an inhibitory effect on the uptake of radiolabelled methionine by the meningioma cells was d...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)04076-5
更新日期:1996-02-27 00:00:00
abstract::Nitrosamine formation from the reaction of nitroprusside with morpholine was found to be a light-dependent reaction. Maximum nitrosation occurred when the reactants were exposed to UV light (lambda = 275-300 nm). However, considerable nitrosation also occurred with light in the visible spectrum up to 500 nm. No signif...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90013-4
更新日期:1988-06-15 00:00:00
abstract::Pancreatic adenocarcinoma cells show characteristics of macrophages as phagocytosis and exocytosis. These phagocytic activities can be inhibited in macrophages by antirheumatic drugs, e.g. gold compounds and antimalarials. We have now tested the activity of auranofin and chloroquine to inhibit growth of a pancreatic t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90109-2
更新日期:1989-01-01 00:00:00
abstract::Sox17, a transcription factor, was considered as an antagonist to inhibit canonical Wnt/β-catenin signaling in several malignant tumors. Extremely little is known about Sox17 in gastric cancer. Therefore, the aim of this study was to elucidate the vital role of Sox17 in the tumorigenesis and progression of gastric can...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.03.024
更新日期:2011-08-28 00:00:00
abstract::Expression of the cytoplasmic soluble form of p53 protein in the different rat colon cancer cell lines transfected and non-transfected with Rous sarcoma virus-33 was studied. Concentrations of the p53 protein were detected by commonly used immunochemical methods after its isolation by affinity chromatography columns w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00345-5
更新日期:1997-12-23 00:00:00
abstract::Chloroform is a liver carcinogen in mice and a kidney carcinogen in rats. It is thought to act through a non-genotoxic-cytotoxic mode of action. Changes in expression of growth control genes accompanying chloroform-induced cytolethality and regeneration may play a part in the development of chloroform-induced tumors. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04123-7
更新日期:1996-03-19 00:00:00
abstract::Chemical agents including 5-iodo-2'-deoxyuridine (IUdR), 4-O-methyl 12-O-tetradecanoyl phorbol-13-acetate (TPA), phorbol, and the tumor promoters teleocidin and TPA were tested for their ability to induce Human T-cell leukemia-lymphoma virus Type I (HTLV-I) expression in the low-virus producer MT-1 cell line and in th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90077-8
更新日期:1988-04-01 00:00:00
abstract::Sperm protein 17 (Sp17) is a highly antigenic, testes-specific protein whose known function is to bind sperm to the zona pellucida. However, the Sp17 gene has been recently detected in normal non-testes tissues and malignant neoplasias. As the role of Sp17 in non-testes tissues is unknown, the characterization of the ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00350-6
更新日期:2002-12-05 00:00:00
abstract::Efficacy of a safe and clinically utilized polyethylene glycol formulation (PEG-3350) to suppress intestinal tumors was investigated in the Apc(min) mouse-model of experimental carcinogenesis. Furthermore, based on our previous finding on the induction of apoptosis in HT-29 cells by PEG, we evaluated its ability to st...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.05.012
更新日期:2004-11-08 00:00:00
abstract::Fumonisin B1 (FB1), a mycotoxin produced by a common corn contaminant Fusarium moniliforme and a hepatocarcinogen in rats, has been previously suggested to act as a poor initiator, but a better promoter of gamma-glutamyltranspeptidase (GGT)-positive rat liver preneoplastic lesions. Using glutathione S-transferase-plac...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00046-9
更新日期:1998-06-05 00:00:00
abstract::Synovial sarcoma is a relatively common soft tissue sarcoma with an aggressive clinical course. Although surgery is currently the first treatment modality, improvement of adjuvant chemotherapy is deemed essential to improve the clinical outcome. Nuclear factor-kappaB (NF-kappaB) is constitutively activated in various ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.07.021
更新日期:2008-12-18 00:00:00
abstract::Gastric adenocarcinoma and esophageal adenocarcinoma are aggressive cancers with a poor prognosis. Therefore, new therapeutic strategies are needed, especially for patients refractory to conventional treatment. Cancer immunotherapy (CIT), is a promising new treatment option and is effective in a proportion of patients...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.11.001
更新日期:2019-02-01 00:00:00
abstract:INTRODUCTION/HYPOTHESIS:Over-expression of the c-Met receptor tyrosine kinase has been described in a variety of cancers and implicated in tumor progression. Unlike some solid tumors, current evidence indicates that c-Met activation in colon cancer is unrelated to gene mutation, is ligand dependent, and occurs via a pa...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.07.007
更新日期:2007-04-18 00:00:00
abstract::Effects of the green tea catechins (GTCs) on the late promotion or progression stage of mammary gland carcinogenesis were examined in female Sprague-Dawley (SD) rats pretreated with 7,12-dimethylbenz(a)anthracene (DMBA). A total of 84 7-week-old rats received a 50 mg/kg body weight intra-gastric dose of DMBA, and star...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04560-0
更新日期:1997-01-30 00:00:00
abstract::Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.10.018
更新日期:2007-06-08 00:00:00
abstract::The occurrence and persistence of DNA fragmentation, as detected by the alkaline elution technique, have been studied in rats treated with single oral doses of the hepatocarcinogen 2-nitropropane (2-NP). A progressive increase of liver DNA fragmentation was observed at doses ranging from 0.5 to 8 mmol/kg; single stran...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90064-o
更新日期:1991-04-01 00:00:00
abstract::Despite recent improvements in chemotherapy and surgery, the problem of non-response osteosarcoma to chemotherapy remains, and is a parameter that is critical for prognosis. The present work investigated the therapeutic value of NVP-BEZ235, a dual class I PI3K/mTOR inhibitor. NVP-BEZ235 inhibited osteosarcoma cell pro...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.11.017
更新日期:2014-03-28 00:00:00
abstract::We investigated the molecular mechanisms responsible for fisetin-induced apoptosis in U266 cells. Fisetin elicited the cytotoxicity in U266 cells, manifested as an increased fraction of the cells with sub-G1 content or stained positively with TUNEL labeling. Fisetin enhanced caspase-3 activation, downregulation of Bcl...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.01.008
更新日期:2012-06-28 00:00:00
abstract::Hepatitis C virus Core plays a vital role in the development of hepatocellular carcinoma; however, its action mechanism is still controversial. Here, we showed that Core down-regulated levels of p16, resulting in inactivation of Rb and subsequent activation of E2F1, which lead to growth stimulation of hepatocytes. For...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.06.012
更新日期:2011-11-01 00:00:00
abstract::The analogs of benzidine were assay for mutagenicity using Salmonella typhimurium TA-98 and TA-100 and a mouse liver enzyme preparation. Only 4-aminobiphenyl produced both frameshift and base pair substitution mutations and 3,3'-dichlorobenzidine was the only compound which was mutagenic without the mammalian enzyme f...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)93137-3
更新日期:1978-01-01 00:00:00
abstract::The first experimental data suggesting that neoplasm development in animals might be influenced by infectious agents were published in the early 1900s. However, conclusive evidence that DNA viruses play a role in the pathogenesis of some human cancers only emerged in the 1950s, when Epstein-Barr virus (EBV) was discov...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2006.05.010
更新日期:2007-03-18 00:00:00
abstract::Membrane glycoprotein synthesis was studied in non-tumorigenic and tumor cells treated with the lymphokine hormone, lymphotoxin, to define the biochemical mechanisms by which lymphotoxin prevents carcinogenesis and inhibits growth of tumor cells. Syrian hamster lymphotoxin increased the synthesis of high molecular wei...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90096-4
更新日期:1983-07-01 00:00:00
abstract::Hepatocellular cancer (HCC) has always been considered a therapeutic challenge, given the cytoxic drug resistant nature of the cancer and associated disorder in liver function, reducing the safety of many conventional chemotherapy agents. The Multikinase inhibitor sorafenib has been found to prolong survival in patien...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2009.07.001
更新日期:2009-12-01 00:00:00
abstract::Oesophageal squamous cell carcinoma (OSCC) is highly prevalent in developing countries but there has been little recent progress into efficacious yet affordable treatment strategies. Drug repurposing is one attractive approach for cancer therapy. Disulfiram (DSF), used to treat alcoholism, inhibits cancer growth and w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.12.026
更新日期:2018-03-28 00:00:00
abstract::Mutations in oncogenes and tumor suppressor genes confer a fitness advantage to cells that can lead to cancer. The tumor phenotype normally results from the interaction of many mutant genes making it difficult to estimate the fitness advantage provided by any oncogene, except when tumors depend on one oncogene only. W...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.01.020
更新日期:2010-08-01 00:00:00
abstract::Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based vaccine delivery system using P5 HER2/neu-der...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.09.016
更新日期:2014-12-01 00:00:00