DNA damage response of A549 cells treated with particulate matter (PM10) of urban air pollutants.

abstract：:The effects of glucocorticoids and cholesterol on morphological transformation have been studied using hamster embryo cells. The cells were exposed sequentially to benzo[a]pyrene (BP) (3 days) and the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) (4 days) before scoring for morphologically transformed colo...

journal_title：Cancer letters

authors： Rivedal E

更新日期：1982-02-01 00:00:00

abstract：:In order to study the interaction between cis-diamminedichloroplatinum(II) (CDDP) and representative human DNA in a highly defined manner, alphoid sequence DNA was isolated from two human parental cancer lines (one of head and neck squamous cell origin, SCC-25, and one of breast carcinoma origin, MCF-7) as well as fro...

journal_title：Cancer letters

authors： Chan V,Elliott KE,Herman TS,Teicher BA

更新日期：1988-12-15 00:00:00

abstract：:To clarify the detailed molecular mechanism underlying cellular responses to nonthermal low-intensity pulsed ultrasound (LIPUS), gene expression patterns and genetic networks in human lymphoma U937 cells were examined using global-scale microarrays and computational gene expression analysis tools. Six hours after LIPU...

journal_title：Cancer letters

authors： Tabuchi Y,Takasaki I,Zhao QL,Wada S,Hori T,Feril LB Jr,Tachibana K,Nomura T,Kondo T

更新日期：2008-11-08 00:00:00

abstract：:Endometrial cancer is the leading gynecologic cancer in women in the United States with 52,630 women predicted to be diagnosed with the disease in 2014. The objective of this study was to determine if progesterone (P4) receptor membrane component 1 (PGRMC1) influenced endometrial cancer cell viability in response to c...

journal_title：Cancer letters

authors： Friel AM,Zhang L,Pru CA,Clark NC,McCallum ML,Blok LJ,Shioda T,Peluso JJ,Rueda BR,Pru JK

更新日期：2015-01-28 00:00:00

abstract：:The levels of 26 kDa-soluble (S) and 30 kDa-membrane-bound (MB) catechol-O-methyltransferase (COMT) polypeptides were determined in paired samples from normal and neoplastic breast tissue of 32 patients with breast cancer. Immunohistochemical staining showed that the COMT reaction in normal mammary tissue was restrict...

journal_title：Cancer letters

authors： Tenhunen J,Heikkilä P,Alanko A,Heinonen E,Akkila J,Ulmanen I

更新日期：1999-09-20 00:00:00

abstract：:Time trends and the geographical variation of mortality from gastric cancer in Spain are analysed. The national (1961-1980) and the provincial (1975-1980) crude death rates as well as the age adjusted death rates were calculated using the population census (years 1960 and 1970) and the figures for national and provinc...

journal_title：Cancer letters

authors： Palmeiro R,Senra A,Garcia-Blanco P,Millan J

更新日期：1988-09-01 00:00:00

abstract：:Interferons are able to enhance the expression of carcinoembryonic antigen (CEA) on tumour cells, allowing improved tumour targeting. In this report the hypothesis is tested that combinations of cytokines may further increase the tumour antigen expression. The combination of both IFN-gamma and IFN-alpha with interleuk...

journal_title：Cancer letters

authors： Verhaar MJ,Damen CA,Zonnenberg BA,Blijham GH

更新日期：1999-05-03 00:00:00

abstract：:One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often lead...

journal_title：Cancer letters

authors： Padler-Karavani V

更新日期：2014-09-28 00:00:00

abstract：:Retinoic acid and retinol induced functional and morphological differentiation of human promyelocytic leukemia cells (HL-60) into mature granulocytes, but did not induce functional or morphological differentiation of mouse myeloid leukemia cells (M1). Cellular retinoic acid-binding protein, but not retinol-binding pr...

journal_title：Cancer letters

authors： Takenaga K,Honma Y,Hozumi M

更新日期：1981-06-01 00:00:00

abstract：:BRAFV600- and MEK1/2-targeting therapies rarely produce durable response in melanoma patients. We investigated five BRAFV600E melanoma cell lines derived from drug-naïve tumor specimens to assess cell death response to encorafenib (Braftovi), a recently FDA-approved BRAFV600 inhibitor. Drug-naïve cell lines (i) did no...

journal_title：Cancer letters

authors： Hartman ML,Gajos-Michniewicz A,Talaj JA,Mielczarek-Lewandowska A,Czyz M

更新日期：2021-02-28 00:00:00

abstract：:Chromosome 22q shows a high frequency of loss of heterozygosity (LOH) in ovarian cancers suggesting the existence of one or more important tumor suppressor genes (TSGs). The tissue inhibitor of metalloproteinase-3 (TIMP-3) is a plausible TSG candidate since it is often encompassed within these regions of LOH. TIMP-3 h...

journal_title：Cancer letters

authors： Liu MC,Choong DY,Hooi CS,Williams LH,Campbell IG

更新日期：2007-03-08 00:00:00

abstract：:Arginine deiminase (ADI), isolated from Mycoplasma cell extracts, has been suggested to inhibit endothelial cell growth in vitro. However, anti-angiogenic activity by ADI has not yet been demonstrated. In this study, we investigated the in vitro effect of recombinant ADI (rADI) on the growth, migration, and tube forma...

journal_title：Cancer letters

authors： Beloussow K,Wang L,Wu J,Ann D,Shen WC

更新日期：2002-09-26 00:00:00

abstract：:The B cell lymphomas associated with Epstein-Barr virus (EBV) are not limited to any specific stage of B cell differentiation but covers widely different B cell phenotypes. In vitro infection of the virus negative tumors with a recombinant EBV strain has provided important insights into virus-tumor interaction. Here, ...

journal_title：Cancer letters

authors： Anastasiadou E,Vaeth S,Cuomo L,Boccellato F,Vincenti S,Cirone M,Presutti C,Junker S,Winberg G,Frati L,Wade PA,Faggioni A,Trivedi P

更新日期：2009-11-01 00:00:00

abstract：:The binding of hematoporphyrin (HP) to human cells of the line NHIK 3025 has been studied with the aid of microfluorometry. HP is concentrated within cells when present in Hank's balanced salt solution in the concentration range 10(-5)--3 x 10(-3) M. The time course of binding is biphasic with a rapid initial binding ...

journal_title：Cancer letters

authors： Christensen T,Moan J

更新日期：1980-04-01 00:00:00

abstract：:As a cellular degradation mechanism, autophagy exerts crucial and complicated effects on HCC development. Liver non-parenchymal cells, including hepatic resident macrophage Kupffer cells, also play important roles in this process. However, most associated studies have focused on the influence of the autophagy level in...

journal_title：Cancer letters

authors： Sun K,Xu L,Jing Y,Han Z,Chen X,Cai C,Zhao P,Zhao X,Yang L,Wei L

更新日期：2017-03-01 00:00:00

abstract：:To discover novel drugs for neuroblastoma treatment, we have previously screened a panel of drugs and identified 30 active agents against neuroblastoma cells. Here we performed microarray gene expression analysis to monitor the impact of these agents on a neuroblastoma cell line and used the connectivity map (cMAP) to...

journal_title：Cancer letters

authors： Gheeya J,Johansson P,Chen QR,Dexheimer T,Metaferia B,Song YK,Wei JS,He J,Pommier Y,Khan J

更新日期：2010-07-01 00:00:00

abstract：:The growth of a transplantable myeloid leukaemia into its syngeneic host is accompanied by a progressive increase in the number of blood monocytes. These were shown to be of host origin and were not derived from the inoculated leukaemia cells. The host response which is responsible for the monocytosis differs from tha...

journal_title：Cancer letters

authors： Gauci CL,Wrathmell A,Alexander P

更新日期：1975-09-01 00:00:00

abstract：:Gene methylation is an important molecular event in prostate carcinogenesis that may have diagnostic and prognostic significance. We evaluated the methylation status of eight genes implicated in prostate carcinogenesis. DNA was extracted from archived paraffin-embedded tumor blocks from 90 prostate cancer patients. Ge...

journal_title：Cancer letters

authors： Woodson K,Hanson J,Tangrea J

更新日期：2004-03-18 00:00:00

abstract：:The family of cyclin-dependent kinase complexes (Cdks) are well known for their role in the cell division cycle. What is less well known, however, is that Cdks also participate in a subset of apoptosis programs. Evidence for the role of Cdks in apoptosis comes from a variety of experimental approaches, including studi...

journal_title：Cancer letters

authors： Golsteyn RM

更新日期：2005-01-20 00:00:00

abstract：:Previous studies have demonstrated that fibroblast growth factor 8b (FGF8b) is up-regulated in a large proportion of prostate cancer patients and that it plays a key role in prostate carcinogenesis. In this study, we designed and synthesized a gN helix domain derived short peptide (termed 8b-13) based on the analysis ...

journal_title：Cancer letters

authors： Li T,Luo W,He D,Wang R,Huang Y,Zeng X,Wang W,Chen X,Gao S,Yu Y,Li X,Wu X

更新日期：2013-10-10 00:00:00

abstract：:Multiple therapeutic strategies have been developed to treat pancreatic cancer. However, the outcomes of these approaches are disappointing. Due to deeper understandings of the pivotal roles of the immune system in pancreatic cancer tumorigenesis and progression, novel therapeutic strategies based on immune cells and ...

journal_title：Cancer letters

authors： Xu JW,Wang L,Cheng YG,Zhang GY,Hu SY,Zhou B,Zhan HX

更新日期：2018-07-01 00:00:00

abstract：:Bone metastasis is a major cause of prostate cancer (PCa) mortality. Although docetaxel chemotherapy initially extends patients' survival, in most cases PCa becomes chemoresistant and eventually progresses without a cure. In this study, we developed a novel small-molecule compound BKM1972, which exhibited potent in vi...

journal_title：Cancer letters

authors： Chen Y,Gera L,Zhang S,Li X,Yang Y,Mamouni K,Wu AY,Liu H,Kucuk O,Wu D

更新日期：2019-04-01 00:00:00

abstract：:Acquired resistance to mechanisms of programmed cell death is one of the hallmarks of cancer. Human melanoma, in advanced stage, is hardly curable, due to development of several strategies that impair apoptosis induced by the death receptor and the mitochondrial pathways of apoptosis. Among these apoptosis escape stra...

journal_title：Cancer letters

authors： Anichini A,Mortarini R,Sensi M,Zanon M

更新日期：2006-07-18 00:00:00

abstract：:The Arp2/3 complex and filamins play important roles in organization of actin cytoskeleton, and thus in cellular morphology and locomotion. We recently identified decreased expression of a gene for one of seven subunits of the Arp2/3 complex, the p41-Arc gene, and silencing of a filamin gene, the FLNc gene, in human g...

journal_title：Cancer letters

authors： Kaneda A,Kaminishi M,Sugimura T,Ushijima T

更新日期：2004-08-30 00:00:00

abstract：:In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Eucalyptus plants were screened. Consequently, the phlorogrucinol-monoterpene derivative, euglobal-G1 (EG-1), was obtained from the leaves of Eucalyptus grandis as an active constituent. EG-1 exhibited...

journal_title：Cancer letters

authors： Takasaki M,Konoshima T,Etoh H,Pal Singh I,Tokuda H,Nishino H

更新日期：2000-07-03 00:00:00

abstract：:Our earlier studies have shown that simultaneous inhibition of glycolysis and pentose phosphate pathway using 2-deoxy-d-glucose (2-DG, an inhibitor of glycolysis) and 6-aminonicotinamide (6-AN, an inhibitor of pentose phosphate pathway) lead to metabolic oxidative stress (MOS), resulting in radiosensitization in malig...

journal_title：Cancer letters

authors： Sharma PK,Bhardwaj R,Dwarakanath BS,Varshney R

更新日期：2010-09-28 00:00:00

abstract：:Gastric cancers with and those without high-frequency microsatellite instability (MSI-H) represent distinctive pathways of carcinogenesis. The aim of this study was to clarify if expression of p53 related genes involved in angiogenesis is differentially regulated between these cancers. We systematically analyzed the e...

journal_title：Cancer letters

authors： Miyamoto N,Yamamoto H,Taniguchi H,Miyamoto C,Oki M,Adachi Y,Imai K,Shinomura Y

更新日期：2007-08-28 00:00:00

abstract：:Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Using the 32P-postlabeling assay we showed that AAI is activated by human recombinant cytochrome P450 (CYP) 1A1, CYP1A2 and NADPH:CYP reductase to species generating DNA ad...

journal_title：Cancer letters

authors： Stiborová M,Sopko B,Hodek P,Frei E,Schmeiser HH,Hudecek J

更新日期：2005-11-18 00:00:00

abstract：:Activation of the cytoplasmic (Ras-Raf-MEK-ERK) signaling cascade was shown to be both, necessary and sufficient for transformation in vitro as well as in vivo. However, over the last years the involvement of stress-activated protein kinases (SAPKs)/Jun N-terminal kinases (JNKs), and their substrate c-Jun in the proce...

journal_title：Cancer letters

authors： Rennefahrt U,Illert B,Greiner A,Rapp UR,Troppmair J

更新日期：2004-11-08 00:00:00

abstract：:Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity ...

journal_title：Cancer letters

authors： Mannello F,Bocchiotti GD,Morano FP,Fratepietro LM,Gazzanelli G

更新日期：1996-01-02 00:00:00