当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Epstein-Barr virus infection leads to partial phenotypic reversion of terminally differentiated malignant B cells.

Epstein-Barr virus infection leads to partial phenotypic reversion of terminally differentiated malignant B cells.

Abstract：

:The B cell lymphomas associated with Epstein-Barr virus (EBV) are not limited to any specific stage of B cell differentiation but covers widely different B cell phenotypes. In vitro infection of the virus negative tumors with a recombinant EBV strain has provided important insights into virus-tumor interaction. Here, we investigated the interaction between EBV and terminally differentiated tumor derived B cells, namely multiple myeloma (MM). The in vitro EBV infected MM expressed restricted viral latency. Acquisition of the virus was accompanied by a partial reprogramming to a mature B cell phenotype. Thus, the plasma cell markers syndecan-1 (CD138), Blimp1 and MUM1 were downregulated, while expression of HLADR, CIITA and TCL1, which are normally not expressed in plasmacytoid cells, was upregulated. The silenced transcription factor gene encoding Pax5 and its target BLNK were activated. Significantly, the free lambda light chains secreted in the medium were reduced in EBV infected MM clones. Collectively, these results suggest that the restricted EBV latency can cause at least partial phenotypic reversion of terminally differentiated B tumor cells. We suggest that the restricted EBV latent gene expression may not only be the consequence but the cause of the mature B cell phenotype, actively participating in the virus persistence.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Anastasiadou E,Vaeth S,Cuomo L,Boccellato F,Vincenti S,Cirone M,Presutti C,Junker S,Winberg G,Frati L,Wade PA,Faggioni A,Trivedi P

doi

10.1016/j.canlet.2009.04.025

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

165-74

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(09)00293-6

journal_volume

284

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Inhibition of phthalocyanine-sensitized photohemolysis of human erythrocytes by polyphenolic antioxidants: description of quantitative structure-activity relationships.

    abstract：:Polyphenolic antioxidants protected against Al-phthalocyanine tetrasulfonate-sensitized photohemolysis of human erythrocytes. A quantitative structure-activity relationship has been obtained to describe the protective effects of di- and trihydroxybenzenes: log cI(50) (microM)=(1.8620+/-1.5565)+(3.6366+/-2.8245) E(1)(7...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00469-9

    authors： Maroziene A,Kliukiene R,Sarlauskas J,Cenas N

    更新日期：2000-08-31 00:00:00

  • Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells.

    abstract：:Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stro...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.02.016

    authors： Saijo A,Goto H,Nakano M,Mitsuhashi A,Aono Y,Hanibuchi M,Ogawa H,Uehara H,Kondo K,Nishioka Y

    更新日期：2018-05-01 00:00:00

  • Growth factors in chronic myelogenous leukemia.

    abstract：:Transforming growth factors (TGFs) are implicated in malignancy, therefore qualitative and quantitative differences of these growth factors in chronic myelogenous leukemia (CML) in chronic phase has been investigated in this report. Induction of anchorage independent growth of BALB/c 3T3 and NRK-49F fibroblasts was us...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(86)90181-3

    authors： Kothari V,Advani SH,Rao SG

    更新日期：1986-09-01 00:00:00

  • Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells.

    abstract：:In the present study, Tbx3, a member of the T-box family of transcription factors, was identified as an up-regulated gene by mRNA differential display in the regression (apoptosis) stage after uracil-induction of papillomatosis in the rat urinary bladder. Immunohistochemical analysis revealed that apoptosis cells are ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.07.051

    authors： Ito A,Asamoto M,Hokaiwado N,Takahashi S,Shirai T

    更新日期：2005-02-28 00:00:00

  • Trabectedin overcomes doxorubicin-resistance, counteracts tumor-immunosuppressive reprogramming of monocytes and decreases xenograft growth in Hodgkin lymphoma.

    abstract：:Classical Hodgkin lymphoma (cHL) tumor cells are surrounded by a protective tumor microenvironment (TME). Trabectedin, an anticancer drug targeting both tumor cells and TME, demonstrated a potent antitumor activity against Hodgkin Reed Sternberg (HRS) cells. It was cytotoxic against cHL cell lines, including the doxor...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.12.015

    authors： Casagrande N,Borghese C,Favero A,Vicenzetto C,Aldinucci D

    更新日期：2021-03-01 00:00:00

  • MITF suppression improves the sensitivity of melanoma cells to a BRAF inhibitor.

    abstract：:Microphthalmia-associated transcription factor (MITF) is expressed in melanomas and has a critical role in melanocyte development and transformation. Because inhibition of MITF inhibits cell growth in melanoma, MITF is a potential therapeutic target molecule. Here, we report the identification of CH6868398, which has ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.09.008

    authors： Aida S,Sonobe Y,Tanimura H,Oikawa N,Yuhki M,Sakamoto H,Mizuno T

    更新日期：2017-11-28 00:00:00

  • The enigmatic effects of caffeine in cell cycle and cancer.

    abstract：:Caffeine may very well be the most frequently ingested neuroactive drug in the world. Mechanistically, caffeine has been reported to affect cell cycle function, induce programmed cell death or apoptosis and perturb key cell cycle regulatory proteins. Although the effects of caffeine have been heavily investigated, muc...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2006.03.032

    authors： Bode AM,Dong Z

    更新日期：2007-03-08 00:00:00

  • Vasohibin 2 promotes human luminal breast cancer angiogenesis in a non-paracrine manner via transcriptional activation of fibroblast growth factor 2.

    abstract：:Vasohibin 2 (VASH2) is an angiogenic factor and cancer-related protein that acts via paracrine mechanisms. Here, we investigated the angiogenic function and mechanism of action of VASH2 in 200 human breast cancer tissues by performing immunohistochemical staining, western blot, indirect sandwich enzyme-linked immunoso...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.09.031

    authors： Tu M,Lu C,Lv N,Wei J,Lu Z,Xi C,Chen J,Guo F,Jiang K,Li Q,Wu J,Song G,Wang S,Gao W,Miao Y

    更新日期：2016-12-28 00:00:00

  • Effect of methylazoxymethanol acetate on adenylate cyclase and 5'-nucleotidase in rat liver plasma membranes.

    abstract：:A single tumorigenic dose of methylazoxymethanol acetate increased adenylate cyclase activity in total liver homogenates 70-100% by the seventh day after treatment. The increased activity occurred in the plasma membranes rather than in the nuclei and was accompanied by a significant increase in 5'-nucleotidase activit...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(75)95764-x

    authors： Zedeck MS,Swislocki NI

    更新日期：1975-11-01 00:00:00

  • Prostate-specific membrane antigen-targeted photodynamic therapy induces rapid cytoskeletal disruption.

    abstract：:Prostate-specific membrane antigen (PSMA), an established enzyme-biomarker for prostate cancer, has attracted considerable attention as a target for imaging and therapeutic applications. We aimed to determine the effects of PSMA-targeted photodynamic therapy (PDT) on cytoskeletal networks in prostate cancer cells. PSM...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2010.04.003

    authors： Liu T,Wu LY,Berkman CE

    更新日期：2010-10-01 00:00:00

  • Angiogenesis in colon hyperplastic polyp.

    abstract：:Despite the significance of tumor angiogenesis and the extensive knowledge on the molecular basis of blood vessel formation in carcinoma of colorectum, no data exist in hyperplastic polyp. This prompted us to examine angiogenesis in hyperplastic polyp. Eleven small hyperplastic polyps, 13 large hyperplastic polyps and...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/S0304-3835(03)00183-6

    authors： Sano Y,Maeda N,Kanzaki A,Fujii T,Ochiai A,Takenoshita S,Takebayashi Y

    更新日期：2005-02-10 00:00:00

  • Therapeutic effect of neural stem cells expressing TRAIL and bortezomib in mice with glioma xenografts.

    abstract：:Treatment of glioblastoma remains a challenge in neuro-oncology. We investigated if treatment with neural stem cells engineered to express membrane-bound TRAIL (NSCs-mTRAIL) alone or in combination with proteasome inhibitors is a feasible therapeutic approach for experimental glioma. Glioma cells showed resistance to ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.06.029

    authors： Balyasnikova IV,Ferguson SD,Han Y,Liu F,Lesniak MS

    更新日期：2011-11-28 00:00:00

  • Mouse trophoblastic cells exhibit a dominant invasiveness phenotype over cancer cells.

    abstract：:Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and a...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2010.08.008

    authors： Fang LQ,Zhang H,Ding XY,Li DQ,Hou XL,Qiao H,Bai J,Wang ZB

    更新日期：2010-12-28 00:00:00

  • Guggulsterone sensitizes glioblastoma cells to Sonic hedgehog inhibitor SANT-1 induced apoptosis in a Ras/NFκB dependent manner.

    abstract：:Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade, Gli1 is also induced by non-canonical pathway...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.03.025

    authors： Dixit D,Ghildiyal R,Anto NP,Ghosh S,Sharma V,Sen E

    更新日期：2013-08-19 00:00:00

  • Inhibition of transforming growth factor-beta/Smad signaling by phosphatidylinositol 3-kinase pathway.

    abstract：:Gastrin-releasing peptide (GRP) activates phosphatidylinositol 3-kinase (PI3-K)/Akt, an important cell survival signaling pathway, to stimulate growth of various cell types. Transforming growth factor (TGF) superfamily ligands activate intracellular Smad signaling to regulate cell growth, differentiation and apoptosis...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.11.007

    authors： Qiao J,Kang J,Ko TC,Evers BM,Chung DH

    更新日期：2006-10-28 00:00:00

  • The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.

    abstract：:We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.12.026

    authors： Jiao L,Hassan MM,Bondy ML,Abbruzzese JL,Evans DB,Li D

    更新日期：2007-01-08 00:00:00

  • Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues.

    abstract：:Activation of telomerase by the induction of a full-length telomerase reverse transcriptase (hTERT) transcript is a critical step during cellular immortalization and malignant transformation. Telomerase activity or hTERT expression has thus served as diagnostic and/or prognostic markers in different types of human mal...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.10.018

    authors： Li W,Li L,Liu Z,Liu C,Liu Z,Strååt K,Björkholm M,Jia J,Xu D

    更新日期：2008-02-18 00:00:00

  • Recent advances in strategies for overcoming hypoxia in photodynamic therapy of cancer.

    abstract：:The selectivity of photodynamic therapy (PDT) derived from the tailored accumulation of photosensitizing drug (photosensitizer; PS) in the tumor microenvironment (TME), and from local irradiation, turns it into a "magic bullet" for the treatment of resistant tumors without sparing the healthy tissue and possible adver...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.07.007

    authors： Pucelik B,Sułek A,Barzowska A,Dąbrowski JM

    更新日期：2020-11-01 00:00:00

  • Blood autoantibodies against tumor-associated antigens as biomarkers in early detection of colorectal cancer.

    abstract：:Multiple studies have shown that cancer patients produce detectable autoantibodies against certain tumor-associated antigens, which might be promising blood biomarkers for early detection of colorectal cancer (CRC). We aimed to provide an overview of published studies on blood autoantibody markers for early detection ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.01.007

    authors： Chen H,Werner S,Tao S,Zörnig I,Brenner H

    更新日期：2014-05-01 00:00:00

  • Resistance factors in colon cancer tissue and the adjacent normal colon tissue: glutathione S-transferases alpha and pi, glutathione and aldehyde dehydrogenase.

    abstract：:Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00059-7

    authors： Hengstler JG,Böttger T,Tanner B,Dietrich B,Henrich M,Knapstein PG,Junginger T,Oesch F

    更新日期：1998-06-05 00:00:00

  • Inhibitors of mTOR overcome drug resistance from topoisomerase II inhibitors in solid tumors.

    abstract：:The present study was performed to investigate the possible role of mTOR inhibitors in restoring chemosensitivity to adriamycin/cisplatin and elucidate the underlying mechanism. Combining adriamycin/cisplatin with torisel synergistically inhibited the cell proliferation in human oropharyngeal carcinoma cell line KB an...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.06.005

    authors： Gaur S,Chen L,Yang L,Wu X,Un F,Yen Y

    更新日期：2011-12-01 00:00:00

  • Integrin receptors and ECM proteins involved in preferential adhesion of colon carcinoma cells to lung cells.

    abstract：:To assess the putative role of extracellular matrix (ECM) proteins on lung cells interacting with integrin receptors on colon carcinoma cells, an in vitro adhesion assay was used to investigate these factors. Tumor necrosis factor (TNF)-alpha treatment of fetal lung cell line MRC 9, upregulated expression of ECM prote...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(03)00208-8

    authors： Karmakar S,Mukherjee R

    更新日期：2003-07-10 00:00:00

  • The biology, function and clinical implications of exosomes in lung cancer.

    abstract：:Exosomes are 30-100 nm small membrane vesicles of endocytic origin that are secreted by all types of cells, and can also be found in various body fluids. Increasing evidence implicates that exosomes confer stability and can deliver their cargos such as proteins and nucleic acids to specific cell types, which subsequen...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2017.08.003

    authors： Zhou L,Lv T,Zhang Q,Zhu Q,Zhan P,Zhu S,Zhang J,Song Y

    更新日期：2017-10-28 00:00:00

  • Nitrated T helper cell epitopes enhance the immunogenicity of HER2 vaccine and induce anti-tumor immunity.

    abstract：:Human epidermal growth factor receptor 2 (HER2) is an attractive target for cancer vaccine. However, autoimmune tolerance prevents vaccines based on HER2 protein from inducing long-lasting, highly effective anti-tumor immunity. In this study, we proved that the introduction of p-nitrophenylalanine in the universal T c...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.05.021

    authors： Tian H,He Y,Song X,Jiang L,Luo J,Xu Y,Zhang W,Gao X,Yao W

    更新日期：2018-08-28 00:00:00

  • Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma.

    abstract：:The etiology of prostatic adenocarcinoma remains unclear. Prostate cancer cells of varying metastatic potential and apoptotic resistance show altered expression of plasma membrane ion channels and unbalanced Ca2+ homeostasis. Ca(2+)-activated Cl(-) channels (CaCCs) are robustly expressed in epithelial cells and functi...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2012.07.015

    authors： Liu W,Lu M,Liu B,Huang Y,Wang K

    更新日期：2012-12-29 00:00:00

  • Formation of mutagens in cooked foods. V. The mutagen reducing effect of soy protein concentrates and antioxidants during frying of beef.

    abstract：:Cooking beef patties results in the formation of mutagens detectable by Salmonella typhimurium TA98 with metabolic activation. Decreased mutagenic activity results when frying beef with added soy protein concentrates (SPC). The reduction in mutagenicity takes place during the cooking process. Whereas fried beef hambur...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90059-3

    authors： Wang YY,Vuolo LL,Spingarn NE,Weisburger JH

    更新日期：1982-07-01 00:00:00

  • Tumor-initiating activity of the beta-blocker ZAMI 1305 in the liver of the female Wistar rat.

    abstract：:A 1-week treatment with the hepatocarcinogen beta-blocker DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1305) induces the appearance of preneoplastic liver lesions--oval cell hyperplasia, basophilic and gamma-glutamyltranspeptidase positive (GGT+) foci--in female Wistar rats, as evidenced by the ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(84)80019-1

    authors： Zavanella T,Presta M,Braga G,Dimito E,Mazzocchi C,Ziliani S,Ragnotti G

    更新日期：1984-11-01 00:00:00

  • miRNA 146a promotes chemotherapy resistance in lung cancer cells by targeting DNA damage inducible transcript 3 (CHOP).

    abstract：:The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.04.028

    authors： Tan W,Liao Y,Qiu Y,Liu H,Tan D,Wu T,Tang M,Zhang S,Wang H

    更新日期：2018-08-01 00:00:00

  • Accumulation of benzoporphyrin derivative in malignant and host cell populations of the murine RIF tumor.

    abstract：:The accumulation of benzoporphyrin derivative (BPD) in malignant and host cell populations of the mouse RIF tumor was studied by flow cytometry analysis of cells dissociated from the tumor tissue. The highest cellular BPD levels were found in a subpopulation of tumor associated macrophages (TAMs) characterized by a hi...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03985-6

    authors： Korbelik M,Krosl G

    更新日期：1995-11-06 00:00:00

  • Fluorescent diagnostics of human gastric cancer and sodium fluorescein accumulation in experimental gastric cancer in rats.

    abstract：:Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (F1). Eighty-five percent of gastric cancers showed positive fluorescence. The F1 distribution in the stomach of...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90163-4

    authors： Braginskaja OV,Lazarev VV,Polsachev VI,Rubin LB,Stoskii VE

    更新日期：1993-04-30 00:00:00