Cellular retinoid-binding proteins in cultured human and mouse myeloid leukemia cells.

abstract：:Currently, animal models are used to test the efficacy of tumor treatment. A significant reduction of tumor mass is lauded as great improvement. As we begin the 21st century, one wonders if this is sufficient and acceptable for cancer treatment. Although the presence of cancer stem cell (CSCs) is not a new phenomenon,...

journal_title：Cancer letters

authors： Nahas G,Bliss SA,Sinha G,Ganta T,Greco SJ,Rameshwar P

更新日期：2015-01-28 00:00:00

abstract：:The effects of caloric restriction on the incidence of mammary tumor development, the levels of the expression of mouse mammary tumor virus (MMTV)- and prolactin-RNA, as well as the levels of serum prolactin, were investigated in virgin RIII/Sa mice, a strain known to display a high incidence of spontaneous mammary tu...

journal_title：Cancer letters

authors： Li HW,Zhao W,Sarkar NH

更新日期：1994-05-16 00:00:00

abstract：:The vectors PAI2, C595 and Herceptin target the membrane-bound uPA, MUC1 and HER2 antigens expressed by cancer cells, respectively. The expression of these receptors was tested in the ovarian cancer cell line OVCAR-3; MUC-1 was strongly expressed (3+), uPA moderately expressed (2+), but HER2 was negative (-). The alph...

journal_title：Cancer letters

authors： Song YJ,Qu CF,Rizvi SM,Li Y,Robertson G,Raja C,Morgenstern A,Apostolidis C,Perkins AC,Allen BJ

更新日期：2006-03-28 00:00:00

abstract：:We evaluated the ability of brain-derived neurotrophic factor (BDNF) to decrease the chemosensitivity of neuroblastoma cells to cisplatin. Two cell lines, one derived from SH-SY5Y (SY5Y-TB8) and the other from SK-N-AS (AS-TB8), transfected with a TrkB plasmid were generated, and used to assess the effects of activatio...

journal_title：Cancer letters

authors： Jaboin J,Hong A,Kim CJ,Thiele CJ

更新日期：2003-04-10 00:00:00

abstract：:These studies examined the impact of dietary corn oil and its major constituent fatty acids on the occurrence of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary DNA adducts. In study 1, rats were fed diets containing 5, 10 or 20% corn oil for 2 weeks prior to DMBA treatment (25 mg/kg). Mammary DNA adducts increa...

journal_title：Cancer letters

authors： Schaffer EM,Milner JA

更新日期：1996-09-10 00:00:00

abstract：:Suspensions of Walker and HeLa cells, rat fibroblasts and human stimulated lymphocytes were incubated over various periods with the synthetic amino steroid, 2 beta,16 beta-dipiperidino-5 alpha-androstane-3 alpha,17 beta-diol dipivalate (DAP). The acute cell destroying effect was found to be exponentially time and dose...

journal_title：Cancer letters

authors： Emminger A,Kahmann E,Savage DS

更新日期：1977-03-01 00:00:00

abstract：:Malignant mesothelioma (MM) frequently exhibits Hippo signaling pathway inactivation (HPI) mainly due to NF2 and/or LATS2 mutations, which leads to the activation of YAP transcriptional co-activator. Here, we show antitumor effects of statin on MM cells with HPI, through the interplay of the mevalonate and Hippo signa...

journal_title：Cancer letters

authors： Tanaka K,Osada H,Murakami-Tonami Y,Horio Y,Hida T,Sekido Y

更新日期：2017-01-28 00:00:00

abstract：:Classical Hodgkin lymphoma (cHL) tumor cells are surrounded by a protective tumor microenvironment (TME). Trabectedin, an anticancer drug targeting both tumor cells and TME, demonstrated a potent antitumor activity against Hodgkin Reed Sternberg (HRS) cells. It was cytotoxic against cHL cell lines, including the doxor...

journal_title：Cancer letters

authors： Casagrande N,Borghese C,Favero A,Vicenzetto C,Aldinucci D

更新日期：2021-03-01 00:00:00

abstract：:Mutations of Ki-ras and p53 genes in hepatocellular carcinomas (HCCs) induced by the choline deficient L-amino acid defined (CDAA) diet in rats were investigated by polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) analysis followed by direct sequencing. Male Fischer 344 rats, 6 weeks old...

journal_title：Cancer letters

authors： Tsujiuchi T,Kido A,Nakae D,Takahama M,Majima T,Kobitsu K,Okajima E,Tsutsumi M,Denda A,Konishi Y

更新日期：1996-11-12 00:00:00

abstract：:BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation...

journal_title：Cancer letters

authors： Fabbro M,Henderson BR

更新日期：2008-05-18 00:00:00

abstract：:Crk is a signaling adaptor protein which is mostly composed of SH2 and SH3 domains, and has been shown to play a pivotal role in cell proliferation, differentiation, and migration. Because Crk was originally isolated as an avian sarcoma virus CT10 encoding oncoprotein v-Crk, we examined a potential role for c-Crk in t...

journal_title：Cancer letters

authors： Nishihara H,Tanaka S,Tsuda M,Oikawa S,Maeda M,Shimizu M,Shinomiya H,Tanigami A,Sawa H,Nagashima K

更新日期：2002-06-06 00:00:00

abstract：:Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This multi-scale heterogeneity poses significant challenges for effective therapies, which ideally must not only distinguish between tumorous and healthy tissue, but also fully address the wide variety of tumorous sub-clones. Commo...

journal_title：Cancer letters

authors： Ivey JW,Bonakdar M,Kanitkar A,Davalos RV,Verbridge SS

更新日期：2016-09-28 00:00:00

abstract：:Bevacizumab (Avastin®, Genentech, CA) was granted accelerated approval by the FDA for metastatic breast cancer in 2008. This occurred after the initial clinical trial, E2100, demonstrated an improvement in progression-free survival (PFS) and overall survival (OS) with the addition of bevacizumab to a standard chemothe...

journal_title：Cancer letters

authors： Afranie-Sakyi JA,Klement GL

更新日期：2015-02-01 00:00:00

abstract：:Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a liga...

journal_title：Cancer letters

authors： Lee JH,Yoon JH,Yu SJ,Chung GE,Jung EU,Kim HY,Kim BH,Choi DH,Myung SJ,Kim YJ,Kim CY,Lee HS

更新日期：2010-09-28 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive disease and current treatment regimens fail to effectively cure PDAC. Development of resistance to current therapy is one of the key reasons for this outcome. Nimbolide (NL), a triterpenoid obtained from Azadirachta indica, exhibits anticancer properties in ...

journal_title：Cancer letters

authors： Kumar S,Inigo JR,Kumar R,Chaudhary AK,O'Malley J,Balachandar S,Wang J,Attwood K,Yadav N,Hochwald S,Wang X,Chandra D

更新日期：2018-01-28 00:00:00

abstract：:We have examined the expression of nitrotyrosine, a marker of peroxynitrite formation, in 55 esophageal cancers by immunohistochemistry. Nitrotyrosine was detected in 21 of 55 (38.2%) esophageal cancers. Comparison of nitrotyrosine expression and the pathological findings showed that there was a significant associatio...

journal_title：Cancer letters

authors： Kato H,Miyazaki T,Yoshikawa M,Nakajima M,Fukai Y,Tajima K,Masuda N,Tsutsumi S,Tsukada K,Nakajima T,Kuwano H

更新日期：2000-05-29 00:00:00

abstract：:Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based vaccine delivery system using P5 HER2/neu-der...

journal_title：Cancer letters

authors： Shariat S,Badiee A,Jalali SA,Mansourian M,Yazdani M,Mortazavi SA,Jaafari MR

更新日期：2014-12-01 00:00:00

abstract：:Expression of cyclooxygenase (COX)-2 protein in preneoplastic and neoplastic lung lesions induced by the administration of 2000 ppm of N-nitrosobis(2-hydroxypropyl)amine (BHP) in the drinking water to Wistar male rats, was examined immunohistochemically. The majority of alveolar/bronchiolar adenomas (ADs) and all aden...

journal_title：Cancer letters

authors： Kitayama W,Denda A,Yoshida J,Sasaki Y,Takahama M,Murakawa K,Tsujiuchi T,Tsutsumi M,Konishi Y

更新日期：2000-02-01 00:00:00

abstract：:Integrin cell adhesion molecules play a crucial role in tumor cell resistance to radio- and chemotherapy and are therefore considered attractive targets for cancer therapy. Here, we assessed the role of β1 integrin-interacting α integrin subunits in more physiological three-dimensional extracellular matrix grown head ...

journal_title：Cancer letters

authors： Steglich A,Vehlow A,Eke I,Cordes N

更新日期：2015-02-28 00:00:00

abstract：:Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous ...

journal_title：Cancer letters

authors： Komatsu K,Kator K,Mitsuda Y,Mine M,Okumura Y

更新日期：1994-02-28 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated wit...

journal_title：Cancer letters

authors： Casarsa C,Bassani N,Ambrogi F,Zabucchi G,Boracchi P,Biganzoli E,Coradini D

更新日期：2011-03-28 00:00:00

abstract：:Standard chemotherapy for pancreatic ductal adenocarcinoma (PDAC), nab-paclitaxel (NPT) plus gemcitabine (Gem), has led to an average survival of 8.5 months. Presently, no therapeutics exist that effectively target the KRAS oncogene, activated in 95% of PDACs, but alternative strategies focus on inhibition of downstre...

journal_title：Cancer letters

authors： Awasthi N,Kronenberger D,Stefaniak A,Hassan MS,von Holzen U,Schwarz MA,Schwarz RE

更新日期：2019-09-10 00:00:00

abstract：:The phenomenon of cellular dormancy has been observed in normal adult stem cells in many different tissues such as the skin, the intestine and the hematopoietic system. These dormant cells have been proposed to be important for life-long self-renewal and for the generation of the different cellular lineages. As tumor ...

journal_title：Cancer letters

authors： Schillert A,Trumpp A,Sprick MR

更新日期：2013-11-28 00:00:00

abstract：:Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication st...

journal_title：Cancer letters

authors： Stapelfeld C,Neumann KT,Maser E

更新日期：2017-10-01 00:00:00

abstract：:The primary aim of this study was to find novel chemopreventive agents effective against breast cancer. Endoplasmic reticulum (ER) stress can induce apoptosis through the unfolded protein response (UPR). 2'-Hydroxy-2,3,5'-trimethoxychalcone (DK143) is a synthetic flavonoid derivative. The present study provides eviden...

journal_title：Cancer letters

authors： Lee DH,Jung Jung Y,Koh D,Lim Y,Lee YH,Shin SY

更新日期：2016-03-01 00:00:00

abstract：:Membrane-type 1 matrix metalloproteinase (MT1-MMP), which hydrolyzes type I collagen and activates MMP-2, are deeply involved in angiogenesis as well as in tumor cell invasion and metastasis. We previously screened a number of natural and synthetic compounds to obtain a specific inhibitor of MT1-MMP and observed that ...

journal_title：Cancer letters

authors： Yamakawa S,Asai T,Uchida T,Matsukawa M,Akizawa T,Oku N

更新日期：2004-07-08 00:00:00

abstract：:Carbaryl (1-naphthyl methyl carbamate: C12H11NO2) CAS Reg. No. 63-25-2) is a widely used broad spectrum carbamate insecticide known to exert various toxic effects on experimental animals. Along with various other toxicological effects carbaryl is reported to increase the incidence of neoplasm in various tissues in rat...

journal_title：Cancer letters

authors： Shukla Y,Antony M,Mehrotra NK

更新日期：1992-02-29 00:00:00

abstract：:Helicobacter pylori (H. pylori) infection is considered a major risk factor for gastric cancer. CagA behaves as a major bacterial oncoprotein playing a key role in H. pylori-induced tumorigenesis. Cancer stem cells (CSCs) are believed to possess the ability to initiate tumorigenesis and promote progression. Although s...

journal_title：Cancer letters

authors： Yong X,Tang B,Xiao YF,Xie R,Qin Y,Luo G,Hu CJ,Dong H,Yang SM

更新日期：2016-05-01 00:00:00

abstract：:Hypoxia-inducible factor 1 alpha (HIF-1 alpha) that regulates genes involved in response to hypoxia and promotes neo-angiogenesis, is a transcriptional factor for vascular endothelial cell growth factor (VEGF). The aim of this study was to examine the expression of HIF-1 alpha and VEGF gene expressions and their relat...

journal_title：Cancer letters

authors： Nakayama K,Kanzaki A,Hata K,Katabuchi H,Okamura H,Miyazaki K,Fukumoto M,Takebayashi Y

更新日期：2002-02-25 00:00:00

abstract：:Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...

journal_title：Cancer letters

authors： Petrara MR,Giunco S,Serraino D,Dolcetti R,De Rossi A

更新日期：2015-12-01 00:00:00