Abstract:
:BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation of BRCA1, but repressed BRCA1-mediated transactivation by up to 75% in transfected cells normalized for nuclear BRCA1 levels. The BRCA1 (C61G) RING mutant transactivation function was not regulated by BARD1. We propose that BARD1 reduces BRCA1 transcriptional activity, and that this at least partly involves BRCA1/BARD1 E3 ubiquitin ligase activity, which is disrupted by the C61G mutation.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Fabbro M,Henderson BRdoi
10.1016/j.canlet.2008.01.001subject
Has Abstractpub_date
2008-05-18 00:00:00pages
189-96issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00002-5journal_volume
263pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::The T-cell lymphoma cell line YACUT was fused with the Mls-1a antigen-responsive non-tumorigenic T-cell line G4 to construct growth-arrested hybrids which could be induced to proliferate in the presence of Mls-1a antigen. Prolonged growth of the hybrids by repeated antigenic stimulation resulted in the emergence of ce...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04135-3
更新日期:1996-03-29 00:00:00
abstract::Aberrant activation of mammalian target of rapamycin complex 1 (mTORC1), caused by loss or inactivation of TSC1/TSC2 protein complex, leads to negative feedback inhibition of Akt. The exact mechanisms of this process are still not fully understood. Here we present evidence for the involvement of STAT3, a known mTORC1 ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.09.006
更新日期:2011-12-27 00:00:00
abstract::Ashwagandha, also called as "Queen of Ayurveda" and "Indian ginseng", is a commonly used plant in Indian traditional medicine, Ayurveda. Its roots have been used as herb remedy to treat a variety of ailments and to promote general wellness. However, scientific evidence to its effects is limited to only a small number ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.11.037
更新日期:2008-04-08 00:00:00
abstract::Cervical cytology specimens prepared as monolayers were analyzed with a combination of high-resolution single-cell image analysis and lower-resolution contextual image analysis. For the latter, quantitative features of cluster architecture, object distribution and background were used to mimic the pathologists global ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90096-5
更新日期:1994-03-15 00:00:00
abstract::Inactivation of antineoplastics is a serious problem in cancer therapy, and prevention of the inactivation is a surpassing strategy for enhancement of their therapeutic effects. BOF-A2, which contains both EM-FU, a masked form of 5-fluorouracil (5-FU), and CNDP, an inhibitor of 5-FU degradation, was developed with thi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00330-9
更新日期:1999-03-22 00:00:00
abstract::Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.03.014
更新日期:2004-08-10 00:00:00
abstract::Retinoids are derivatives of vitamin A that include all trans-retinoic acid (ATRA), 13-cis-retinoic acid, (13-cis-RA), and fenretinide (4-HPR). High levels of either ATRA or 13-cis-RA can cause arrest of cell growth and morphological differentiation of human neuroblastoma cell lines, and phase I trials showed that hig...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/s0304-3835(03)00108-3
更新日期:2003-07-18 00:00:00
abstract::Dihydroambazone (DHA) is a water-soluble derivative of the experimental anticancer drug ambazone. In vitro, a combination of DHA and human recombinant tumor necrosis factor alpha (TNF) exerted a strong synergism of cytotoxicity against both mouse melanoma B16K cells and the TNF-sensitive mouse fibroblast line L-M (S)....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90032-s
更新日期:1990-11-05 00:00:00
abstract::Accumulating evidence suggested that the irreversible tyrosine kinase inhibitors (TKIs) have potential to override the acquired resistance to target-based therapies. Herein, we reported IC-4 as a novel irreversible TKI for epidermal growth factor receptor (EGFR). IC-4 potentially suppressed proliferation, induced apop...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.07.005
更新日期:2013-10-28 00:00:00
abstract::Third generation bisphosphonates (BPs), including YM175 and YM529, are known to inhibit bone resorption. The aim of this study was to evaluate the anti-tumor effects of these drugs on murine osteosarcoma cell lines, in terms of proliferation and apoptosis. We found that both YM175 and YM529 strongly inhibited the in v...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.06.041
更新日期:2006-07-08 00:00:00
abstract::Glucose and glutamine metabolism of two microregions of human infiltrating ductile breast cancer, the center and the periphery, was studied and the results were compared with those of healthy mammary glands. In general, the activities of glycolytic enzymes and of phosphate-dependent glutaminase were as follows: center...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.04.018
更新日期:2004-12-28 00:00:00
abstract::Gastric adenocarcinoma and esophageal adenocarcinoma are aggressive cancers with a poor prognosis. Therefore, new therapeutic strategies are needed, especially for patients refractory to conventional treatment. Cancer immunotherapy (CIT), is a promising new treatment option and is effective in a proportion of patients...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.11.001
更新日期:2019-02-01 00:00:00
abstract::The carcinogenic effect of dimethylnitrosamine (DMN) s.c. injected at two different dose levels was studied in laboratory bred European hamsters (EH) and data compared to findings for captured EH. Malignant haemangioendotheliomas of the liver and kidney, hepatocellular carcinomas and cholangiocarcinomas were induced. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(78)92972-5
更新日期:1978-01-01 00:00:00
abstract::The growth of a transplantable myeloid leukaemia into its syngeneic host is accompanied by a progressive increase in the number of blood monocytes. These were shown to be of host origin and were not derived from the inoculated leukaemia cells. The host response which is responsible for the monocytosis differs from tha...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(75)94893-4
更新日期:1975-09-01 00:00:00
abstract::The rate and extent of metastasis by prostate adenocarcinoma-III cells was enhanced in Lobund-Wistar rats by administration of immune-suppressive cyclosporine A. PA-III cells spread from the subcutaneous PA-III-derived tumor, through ipsilateral lymph nodes, to the lungs in which they developed secondary tumors. Swoll...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04538-7
更新日期:1997-01-01 00:00:00
abstract::Despite the significance of tumor angiogenesis and the extensive knowledge on the molecular basis of blood vessel formation in carcinoma of colorectum, no data exist in hyperplastic polyp. This prompted us to examine angiogenesis in hyperplastic polyp. Eleven small hyperplastic polyps, 13 large hyperplastic polyps and...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/S0304-3835(03)00183-6
更新日期:2005-02-10 00:00:00
abstract::Cancers of the gastrointestinal (GI) tract continue to represent a major health problem, despite progress in therapy. Gut microbiota is a key element related to the genesis of GI cancers, countless papers addressing this burning issue across the world. We provide an updated knowledge of the involvement of gut microbio...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.08.013
更新日期:2014-04-10 00:00:00
abstract::Human epidermal growth factor receptor 2 (HER2), a member of the HER family of tyrosine kinases and a binding partner of Heat shock protein 90 (Hsp90), is found amplifies in approximately 25% breast cancers. Treatment of HER2+ breast cancers has been greatly improved in recent years, but the accompanying upregulation ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.10.040
更新日期:2015-01-28 00:00:00
abstract::Recently developed quantitative and high-throughput technologies that allow automated and rapid screening of the whole genome, transcriptome and proteome have revolutionized the field of cancer genetics. At the same time, new challenges are met, e.g. the need for improved data analysis and standardization of tumor sam...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/s0304-3835(03)00084-3
更新日期:2003-07-18 00:00:00
abstract::Starvation-induced hypoglycaemia and streptozotocin-induced diabetes suppressed the growth of Ehrlich ascites tumor in mice. The suppression of tumor growth by diabetes was alleviated by administration of insulin. The number of glucose carriers on tumour cells was found to be reduced in diabetes and partial resumption...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90035-7
更新日期:1985-09-30 00:00:00
abstract::In vitro and pre-clinical studies have suggested that addition of the diet-derived agent curcumin may provide a suitable adjunct to enhance efficacy of chemotherapy in models of colorectal cancer. However, the majority of evidence for this currently derives from established cell lines. Here, we utilised patient-derive...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.05.005
更新日期:2015-08-10 00:00:00
abstract::Doxorubicin (dox) is an anthracycline antibiotic which is broadly used in solid tumors. Long-term therapy with this drug is accompanied by potentially lethal, dose-dependent side effects. Several reports suggest that oxygen free radicals produced during the metabolic activation of dox may have toxic effects on heart m...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)04021-8
更新日期:1996-01-19 00:00:00
abstract::Transcripts from the murine gene family proliferin, which are increased by a wide assortment of chemical promoters of C3H10T1/2 cell morphological transformation, were shown to be induced by tri-n-butyltin chloride at concentrations above 50 nM. Two-stage transformation assays, with 3-methylcholanthrene as inducer and...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90112-m
更新日期:1993-07-30 00:00:00
abstract::Cancer results from the interaction of multiple aberrations including activation of dominant oncogenes and upregulation of signal transduction pathways. Identification of the genes involved in malignant transformation is a pre-requisite for understanding cancer and improving its diagnosis and treatment. Quite a few of...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2007.04.015
更新日期:2007-10-08 00:00:00
abstract::Growing evidence from epidemiologic and preclinical studies suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, colorectal cancer, and hepatocellular carcinoma. However, there is also evidence indicating the absence of...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.09.001
更新日期:2014-04-10 00:00:00
abstract::Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.05.043
更新日期:2008-11-18 00:00:00
abstract::Hepatitis B virus (HBV) is a major etiologic agent of hepatocellular carcinoma (HCC). However, the molecular mechanism by which HBV infection contributes to HCC development is not fully understood. Here, we initially showed that HBV stimulates the production of cancer stem cells (CSCs)-related markers (CD133, CD117 an...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.04.017
更新日期:2017-08-01 00:00:00
abstract::Costunolide (CT), a sesquiterpene lactone constituent isolated from Saussurea lappa (Compositae), exerted an antiangiogenic effect. CT selectively inhibited the endothelial cell proliferation induced by vascular endothelial growth factor (VEGF). Further, CT was also found to inhibit the VEGF-induced chemotaxis of huma...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00361-0
更新日期:2002-12-10 00:00:00
abstract::Antimutagenic activity of copper chlorophyllin against various carcinogenic mutagens was assayed with Drosophila genotoxicity tests, i.e., the wing spot test for detecting somatic cell mutations and the DNA repair test for detecting DNA damage. In these tests, Drosophila larvae were fed carcinogens together with chlor...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90313-1
更新日期:1994-08-15 00:00:00
abstract::The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.04.028
更新日期:2018-08-01 00:00:00