BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters.

Abstract:

:BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation of BRCA1, but repressed BRCA1-mediated transactivation by up to 75% in transfected cells normalized for nuclear BRCA1 levels. The BRCA1 (C61G) RING mutant transactivation function was not regulated by BARD1. We propose that BARD1 reduces BRCA1 transcriptional activity, and that this at least partly involves BRCA1/BARD1 E3 ubiquitin ligase activity, which is disrupted by the C61G mutation.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Fabbro M,Henderson BR

doi

10.1016/j.canlet.2008.01.001

subject

Has Abstract

pub_date

2008-05-18 00:00:00

pages

189-96

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(08)00002-5

journal_volume

263

pub_type

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