Abstract:
:Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a ligand for CRABP-II, induced HCC cell apoptosis more effectively in hypoxia than in normoxia, whereas hypoxia-induced CRABP-II expression attenuated RA-induced apoptosis. Inhibition of CRABP-II enhanced RA-induced apoptosis and sensitized RA-resistant HCC cells to RA cytotoxicity by attenuating p42/44 MAPK and Akt activation. Therefore, RA/CRABP-II signal modulation is therapeutically implicated in infiltrative HCCs exposed to hypoxia.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Lee JH,Yoon JH,Yu SJ,Chung GE,Jung EU,Kim HY,Kim BH,Choi DH,Myung SJ,Kim YJ,Kim CY,Lee HSdoi
10.1016/j.canlet.2010.03.005subject
Has Abstractpub_date
2010-09-28 00:00:00pages
229-35issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(10)00142-4journal_volume
295pub_type
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