Abstract:
:Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated with specific patterns of expression of a selected set of genes related to EMT, cell polarity and stemness features. The association between MPM histologies and genes expression were explored using active and passive Principal Components Analysis-based biplots and PAM analysis that provided evidence that with respect to normal tissues, MPMs histologies were better characterized by specific patterns of expression of genes involved in EMT activation, cell polarity and stemness.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Casarsa C,Bassani N,Ambrogi F,Zabucchi G,Boracchi P,Biganzoli E,Coradini Ddoi
10.1016/j.canlet.2011.01.009subject
Has Abstractpub_date
2011-03-28 00:00:00pages
136-43issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(11)00022-Xjournal_volume
302pub_type
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