Abstract:
:The study describes the kinetics of demethylation of mononitrosocaffeidine (MNC), a new asymmetric N-nitrosamine derived from caffeine. The demethylation of its precursor compound caffeidine was also studied. The results presented here suggest (a) that liver microsomes from fasted rats preferentially demethylate the N-methylnitrosamine group in MNC indicating the demethylation by cytochrome P450IIE1, (b) demethylation of MNC shows two apparent Km values, one of 117-166 microM responsible for the demethylation at the N-methylnitrosamino group of MNC, and the other Km of 1.84-2.26 mM for the remaining N-demethylations, (c) in contrast, caffeidine is a low affinity substrate for microsomal demethylation as indicated by a high Km of 14.3-16.3 mM, and (d) the demethylation at amino-N amino-N, and N-1 in both these compounds are mainly catalysed by P450 enzymes induced by Aroclor 1245 in rats.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Razdan R,Frei E,Spiegelhalder B,Siddiqi Mdoi
10.1016/0304-3835(94)90071-xsubject
Has Abstractpub_date
1994-04-29 00:00:00pages
117-22issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(94)90071-Xjournal_volume
79pub_type
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