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Simultaneous mitochondrial Ca(2+) overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells.

Abstract：

:In this study, we investigated the role of Ca(2+) in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca(2+) overload selectively in the malignant breast cancer cells, but not in the normal breast cell, contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. In addition, we found that simultaneous inhibition of the mitochondrial Na(+)/Ca(2+) exchanger (mNCX) and proteasomes can trigger a sustained mitochondrial Ca(2+) overload and effectively induce paraptosis in malignant breast cancer cells.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Yoon MJ,Kim EH,Kwon TK,Park SA,Choi KS

doi

10.1016/j.canlet.2012.05.018

subject

Has Abstract

pub_date

2012-11-28 00:00:00

pages

197-209

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(12)00312-6

journal_volume

324

pub_type

杂志文章

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