Abstract：
:Celecoxib has a potential role for oral cancer chemoprevention but its systemic side effects are a concern. Topical chemoprevention is a promising way to reduce the toxicity. This study was designed to determine whether topical application of polymer delivered celecoxib would have an inhibitory effect on human oral carcinoma cells. Seventeen nude mice were intradermally inoculated with the carcinoma cells, and then were divided into control and treatment groups. Tumor growth was measured for 15 days, at which significant difference was found between two groups (P<0.001). This study indicates a potential role of polymer film delivered celecoxib for topical inhibition of oral cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wang Z,Polavaram R,Shapshay SMdoi
10.1016/s0304-3835(03)00272-6keywords:
subject
Has Abstractpub_date
2003-07-30 00:00:00pages
53-8issue
1eissn
0304-3835issn
1872-7980pii
S0304383503002726journal_volume
198pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Glioblastoma (GBM) has limited therapeutic options. DNA repair mechanisms contribute GBM cells to escape therapies and re-establish tumor growth. Multiple studies have shown that POLD2 plays a critical role in DNA replication, DNA repair and genomic stability. We demonstrate for the first time that POLD2 is highly exp...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.01.011
更新日期：2020-07-10 00:00:00
abstract：:Metastasis is a major cause of poor prognosis in patients suffered with salivary adenoid cystic carcinoma (SACC), in which many factors are implicated. In this study, we identified that IGFBP2, overexpressed in SACC, correlated positively with perineural invasion or metastasis and indicated worse outcome. Moreover, IG...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.06.008
更新日期：2018-09-28 00:00:00
abstract：:Tumor biopsies obtained from 25 Saudi Arab patients with nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Barr virus (EBV) DNA detected by the polymerase chain reaction (PCR) and for the incidence of p53 mutations screened by a combination of PCR, single strand conformation polymorphism (SSCP) ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90011-6
更新日期：1994-07-29 00:00:00
abstract：:Multidrug resistance (MDR) interferes with the efficiency of chemotherapy. Therefore, developing novel anti-cancer agents that can overcome MDR is necessary. Here, we screened a series of colchicine binding site inhibitors (CBSIs) and found that 5-(3, 4, 5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) displa...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.05.016
更新日期：2017-08-28 00:00:00
abstract：:Gastric adenocarcinoma and esophageal adenocarcinoma are aggressive cancers with a poor prognosis. Therefore, new therapeutic strategies are needed, especially for patients refractory to conventional treatment. Cancer immunotherapy (CIT), is a promising new treatment option and is effective in a proportion of patients...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.11.001
更新日期：2019-02-01 00:00:00
abstract：:Estrogens are important for the development and growth of estrogen receptor (ER)-positive breast cancer, for which anti-estrogen therapy is one of the most effective treatments. However, its efficacy can be limited by either de novo or acquired resistance. Aromatase is a key enzyme for the biosynthesis of estrogens, a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.05.003
更新日期：2014-08-28 00:00:00
abstract：:Experiments were conducted to determine whether gamma-ray-induced genetic damage in parental rats can lead to the development of cancer in their offspring rats using glutathione S-transferase-positive (GST-P+) hepatic foci with or without the addition of diethylnitrosamine (DEN), a carcinogen. A single 1 Gy whole-body...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00155-4
更新日期：1998-10-23 00:00:00
abstract：:The important goal of cancer drug discovery is to develop therapeutic agents that are effective, safe, and affordable. In the present study, we demonstrated that alantolactone, which is a sesquiterpene lactone, has potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal tran...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.11.049
更新日期：2015-02-01 00:00:00
abstract：:Tissue samples from germ-free and conventional rats fed pectins with different degrees of esterification (DE) were tested for containing indigenous DNA adducts (I-compounds). For 21 days groups of six germ-free and 10 conventional rats each were fed either pectin-free or with diets containing 7.5% of three differently...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04621-1
更新日期：1997-03-19 00:00:00
abstract：:Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2010.08.008
更新日期：2010-12-28 00:00:00
abstract：:Peroxiredoxin 2 (Prdx2) has been shown to act as an antioxidant whose main function is to reduce hydrogen peroxide (H2O2) in cells, and Prdx2 is abnormally elevated in colorectal cancer (CRC). However, the functional significance of this up-regulation and the detailed molecular mechanism behind the regulatory effect o...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.10.002
更新日期：2014-02-28 00:00:00
abstract：:The acquisition and persistence of fetal microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Fetal microchimerism has been associated with several classical autoimmune diseases, but its role in normal health remains undefi...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.07.025
更新日期：2009-04-08 00:00:00
abstract：:The purpose of this study was to investigate the possible role of PI-3K/Akt2 pathway in docetaxel-induced apoptosis. Here we showed that transfection of full-length Akt2 into breast and ovarian cancer cells could provoke Akt phosphorylation and induce an enhanced resistance to docetaxel. FN adhesion promoted Akt phosp...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.11.022
更新日期：2008-03-08 00:00:00
abstract：:The phenomenon of cellular dormancy has been observed in normal adult stem cells in many different tissues such as the skin, the intestine and the hematopoietic system. These dormant cells have been proposed to be important for life-long self-renewal and for the generation of the different cellular lineages. As tumor ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2013.04.019
更新日期：2013-11-28 00:00:00
abstract：:Cucurbitacin B (CuB), has recently emerged as a potent anticancer agent; however, its efficacy in non-small-cell lung cancer (NSCLC) and the mechanism(s) initiating its biological effects remain largely unclear. In this study, CuB potently suppressed the growth of four NSCLC cells (H1299, A549, HCC-827 and H661) in vi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.01.008
更新日期：2013-05-10 00:00:00
abstract：:CD95, TNFR1, TRAILR1 and TRAILR2 belong to a subgroup of TNF receptors which is characterized by a conserved cell death-inducing protein domain that connects these receptors to the apoptotic machinery of the cell. Activation of death receptors in malignant cells attracts increasing attention as a principle to fight ca...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2010.12.019
更新日期：2013-05-28 00:00:00
abstract：:Gene delivery vectors, including adenovirus (Ad) and adeno-associated virus (AAV), are inefficient and non-selective for cancer due to low levels of viral receptors with high levels on other tissues, including liver. We tested Ads and AAVs with the SIGYPLP-targeting peptide inserted into virus capsids for transduction...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.07.003
更新日期：2003-11-25 00:00:00
abstract：:Vesnarinone (OPC-8212; 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone ) is a synthetic oral cardiotonic agent that has been used for the treatment of patients with congestive heart failure. Six days of treatment with 30 microg/ml of vesnarinone induced 20-80% growth inhibitions in five out of...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00061-0
更新日期：1999-06-01 00:00:00
abstract：:Aquaporin 3 (AQP3) and c-Met are both overexpressed in human gastric carcinoma and highly associated with its metastasis and invasion. However, it still remains unknown whether c-Met and AQP3 correlate with each other. Herein, we demonstrated that c-Met expression in gastric cancer tissues significantly correlated wit...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.12.040
更新日期：2012-06-01 00:00:00
abstract：:We investigated the effects of the ethyl acetate extract of grapefruit juice (GFJ), that of orange juice (OJ) and their components on the uptake of [(3)H]vincristine into adriamycin-resistant human myelogenous leukemia cells. Its uptake was increased by the extracts of GFJ and OJ up to 7- and 3-fold, respectively, as ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00549-8
更新日期：2000-11-10 00:00:00
abstract：:Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90141-6
更新日期：1983-05-01 00:00:00
abstract：:We investigated the influence of TNF-alpha on the metastasis of cancer cells. Treatment of cultured colon 26 cells with TNF-alpha enhanced metastatic properties including production of MMP-9, adhesion, migration and invasion. Cells treated with TNF-alpha in vitro showed marked potential to metastasize to the lung and ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.12.027
更新日期：2005-12-08 00:00:00
abstract：:Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00059-7
更新日期：1998-06-05 00:00:00
abstract：:We have examined the expression of nitrotyrosine, a marker of peroxynitrite formation, in 55 esophageal cancers by immunohistochemistry. Nitrotyrosine was detected in 21 of 55 (38.2%) esophageal cancers. Comparison of nitrotyrosine expression and the pathological findings showed that there was a significant associatio...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00358-x
更新日期：2000-05-29 00:00:00
abstract：:The present study was conducted to investigate protein levels of inducible NO synthase (iNOS) and cayclooxygenase-2 (COX-2) in human colon cancer tissues. Significant increase of iNOS and COX-2 levels in tumors as compared to paired normal tissue was observed in 15 and 28, respectively, of 29 cases investigated. No co...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.08.014
更新日期：2006-08-08 00:00:00
abstract：:Citral inhibits the formation of retinoic acid from retinol in mouse epidermis. Since skin-carcinogenesis is sensitive to retinoid status, and retinoic acid may be the active form of vitamin A in the epidermis, citral was tested for its ability to modulate tumor promotion in a two-stage skin-carcinogenesis study in ha...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90189-o
更新日期：1991-01-01 00:00:00
abstract：:Hepatitis C virus Core plays a vital role in the development of hepatocellular carcinoma; however, its action mechanism is still controversial. Here, we showed that Core down-regulated levels of p16, resulting in inactivation of Rb and subsequent activation of E2F1, which lead to growth stimulation of hepatocytes. For...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.06.012
更新日期：2011-11-01 00:00:00
abstract：:Mining and mineral processing are important industries in the United States. A large number of workers are potentially exposed to silica during mining and to glass fibers during manufacturing. There is a concern regarding lung cancer risk among workers exposed to silica and glass fibers. Our previous studies showed th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(96)04546-6
更新日期：1997-01-15 00:00:00
abstract：:Cyclin A is an S and G2/M phase regulatory protein and associates with Skp 2 in many transformed cells. Our previous results showed that 12 (39%) and 17 (55%) out of 31 hepatocellular carcinoma (HCC) patients exhibited higher protein expression levels of cyclin A and Skp 2, respectively, in their tumorous compared to ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00352-8
更新日期：1999-05-03 00:00:00
abstract：:Interleukin-6 (IL-6) contributes to a multitude of physiological and pathophysiological processes. We sought to determine the level of the IL-6 in serum and tumoral tissue of patients with staging of the tumor and whether serum IL-6 level in patients with colorectal cancer correlate with tumoral tissue level of it. Se...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.12.003
更新日期：2006-11-28 00:00:00
