Fetal microchimerism and cancer.

abstract：:Acquired resistance to mechanisms of programmed cell death is one of the hallmarks of cancer. Human melanoma, in advanced stage, is hardly curable, due to development of several strategies that impair apoptosis induced by the death receptor and the mitochondrial pathways of apoptosis. Among these apoptosis escape stra...

journal_title：Cancer letters

authors： Anichini A,Mortarini R,Sensi M,Zanon M

更新日期：2006-07-18 00:00:00

abstract：:N-α-Acetyltransferase 10 protein (Naa10p) mediates N-terminal acetylation of nascent proteins. Oncogenic or tumor suppressive roles of Naa10p were reported in cancers. Here, we report an oncogenic role of Naa10p in promoting metastasis of osteosarcomas. Higher NAA10 transcripts were observed in metastatic osteosarcoma...

journal_title：Cancer letters

authors： Chien MH,Lee WJ,Yang YC,Tan P,Pan KF,Liu YC,Tsai HC,Hsu CH,Wen YC,Hsiao M,Hua KT

更新日期：2018-10-01 00:00:00

abstract：:Aquaporin 3 (AQP3) and c-Met are both overexpressed in human gastric carcinoma and highly associated with its metastasis and invasion. However, it still remains unknown whether c-Met and AQP3 correlate with each other. Herein, we demonstrated that c-Met expression in gastric cancer tissues significantly correlated wit...

journal_title：Cancer letters

authors： Wang J,Gui Z,Deng L,Sun M,Guo R,Zhang W,Shen L

更新日期：2012-06-01 00:00:00

abstract：:Specific [3H]fucose-labeled glycoproteins were found in the serum of rats bearing Zajdela hepatoma, which possess different isoelectric points in comparison with serum glycoproteins from normal rats. The electrophoretic profile of the serum glycoproteins is significantly altered. There is approximately a 2.5 times inc...

journal_title：Cancer letters

authors： Ivanov D,Antonova M,Stoilov J,Zacharieva S,Gavazova E,Ivanov S

更新日期：1998-03-13 00:00:00

abstract：:Bombesin-like peptides (BLP) and their receptors are widely distributed throughout the intestine and are potential mitogens for gastrointestinal cancers. In this study we characterized the proliferation induced by BLP in the human adenocarcinoma cell line HT-29. The number of HT-29 cells, partially serum deprived (1% ...

journal_title：Cancer letters

authors： Cassano G,Resta N,Gasparre G,Lippe C,Guanti G

更新日期：2001-10-30 00:00:00

abstract：:We have developed a monoclonal antibody (designated 1D7) which recognizes an M(r) 7-kDa plasma membrane protein overexpressed in ovarian MDR cancer cells. The expression of the M(r) 7-kDa protein in various human multidrug-resistant and drug-sensitive cell lines was analysed by Western blot and flow cytometry methods....

journal_title：Cancer letters

authors： Yang X,Pagé M

更新日期：1995-01-27 00:00:00

abstract：:The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases an...

journal_title：Cancer letters

authors： Kuroda Y,Tsukino H,Nakao H,Imai H,Katoh T

更新日期：2003-01-10 00:00:00

abstract：:This study was carried out to evaluate the diagnostic utility of autofluorescence photography for oral mucosal lesions. The materials consisted of 15 chemically-induced lesions containing carcinomas in 15 hamsters, and 32 oral lesions in 30 patients. In the animal models, orange fluorescence was detected in all squamo...

journal_title：Cancer letters

authors： Onizawa K,Saginoya H,Furuya Y,Yoshida H

更新日期：1996-11-12 00:00:00

abstract：:Fluorescence-activated cell sorting (FACS) based on the surface marker CD133 is the most common method for isolating glioma stem cells (GSCs) from heterogeneous glioma cell populations. Optimization of this method will have profound implications for the future of GSC research. Five commonly used digestion reagents, Li...

journal_title：Cancer letters

authors： Lv D,Ma QH,Duan JJ,Wu HB,Zhao XL,Yu SC,Bian XW

更新日期：2016-07-10 00:00:00

abstract：:Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous ...

journal_title：Cancer letters

authors： Komatsu K,Kator K,Mitsuda Y,Mine M,Okumura Y

更新日期：1994-02-28 00:00:00

abstract：:Natural products play a pivotal role in medicine especially in the cancer arena. Many drugs that are currently used in cancer chemotherapy originated from or were inspired by nature. Jerantinine B (JB) is one of seven novel Aspidosperma indole alkaloids isolated from the leaf extract of Tabernaemontana corymbosa. Prel...

journal_title：Cancer letters

authors： Qazzaz ME,Raja VJ,Lim KH,Kam TS,Lee JB,Gershkovich P,Bradshaw TD

更新日期：2016-01-28 00:00:00

abstract：:It is well documented that CD44 plays an important role in tumor metastasis. We investigated whether there is a correlation between the expression of its isoforms in prostate cancer cells and patient prognosis using 72 cases with biopsy specimens. Immunohistochemistry demonstrated expression of CD44H (68.1%), v6 (36.1...

journal_title：Cancer letters

authors： Takahashi S,Kimoto N,Orita S,Cui L,Sakakibara M,Shirai T

更新日期：1998-07-03 00:00:00

abstract：:Multiple studies have shown that cancer patients produce detectable autoantibodies against certain tumor-associated antigens, which might be promising blood biomarkers for early detection of colorectal cancer (CRC). We aimed to provide an overview of published studies on blood autoantibody markers for early detection ...

journal_title：Cancer letters

authors： Chen H,Werner S,Tao S,Zörnig I,Brenner H

更新日期：2014-05-01 00:00:00

abstract：:Sorafenib has been used as a clinical targeted therapy for hepatocellular carcinoma (HCC) for more than a decade. In 2017, regorafenib was approved for HCC treatment and has since been reported to prolong the survival of advanced HCC patients after treatment failure with sorafenib. However, there has been no direct sy...

journal_title：Cancer letters

authors： Liu S,Du Y,Ma H,Liang Q,Zhu X,Tian J

更新日期：2019-07-01 00:00:00

abstract：:Cucurbitacin B is a natural anti-cancer compound found in Cucurbitaceae. Although the anti-cancer activity of cucurbitacin B in human leukemia cells has been reported, the underlining mechanism is still unclear. To clarify its anti-cancer activity and the mechanism of action, five different leukemia cell lines (CCRF-C...

journal_title：Cancer letters

authors： Chan KT,Li K,Liu SL,Chu KH,Toh M,Xie WD

更新日期：2010-03-01 00:00:00

abstract：:Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This multi-scale heterogeneity poses significant challenges for effective therapies, which ideally must not only distinguish between tumorous and healthy tissue, but also fully address the wide variety of tumorous sub-clones. Commo...

journal_title：Cancer letters

authors： Ivey JW,Bonakdar M,Kanitkar A,Davalos RV,Verbridge SS

更新日期：2016-09-28 00:00:00

abstract：:Imatinib has revolutionized treatment strategies for chronic myeloid leukemia patients: long-term overall survival was reported to be up to 80% at 8 years of follow-up in respondent patients. Despite the straightforward results obtained, it has been estimated a failure rate per year of 2-4%. Several attempts to improv...

journal_title：Cancer letters

authors： Breccia M,Alimena G

更新日期：2012-09-28 00:00:00

abstract：:Overall survival and quality of life of patients with metastatic colorectal cancer (mCRC) have improved due to the development of standard systemic treatment. However, many patients are still suffering from the eventual progression of cancer, treatment-related toxicities, and the economic burden of new drugs. Salvage ...

journal_title：Cancer letters

authors： Woo IS,Jung YH

更新日期：2017-08-01 00:00:00

abstract：:A 65K protein, known for promoting nucleocytoplasmic mRNA transport in a cell-free system, was previously found in fetal and tumor cells of the rat. The primary objective of this study was to show specificity of immunohistochemical staining for the 65K protein in the livers of rats subjected to a hepatocarcinogenesis ...

journal_title：Cancer letters

authors： Hanausek-Walaszek M,Del Rio M,Adams AK

更新日期：1989-12-01 00:00:00

abstract：:Forty female CBA mice aged 3-4 months were exposed twice a week during 2 months to intravaginal applications of polyurethane sponges impregnated with 0.1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in triethyleneglycol. Three hours after each application the sponges were taken out. Starting from the day of the ...

journal_title：Cancer letters

authors： Anisimov VN,Zabezhinski MA,Popovich IG,Zaripova EA,Musatov SA,Andre V,Vigreux C,Godard T,Sichel F

更新日期：2000-08-11 00:00:00

abstract：:Several enzymes metabolize the toxic aldehydes produced during lipid peroxidation, such as 4-hydroxynonenal. During carcinogenesis induced by diethylnitrosamine in rat liver, an increase in aldehyde dehydrogenase, in comparison with normal liver, has already been shown. This paper demonstrates that, although to a less...

journal_title：Cancer letters

authors： Canuto RA,Muzio G,Maggiora M,Biocca ME,Dianzani MU

更新日期：1993-02-01 00:00:00

abstract：:Immunogenic, methylcholanthrene-induced sarcomas failed to elicit the production of rapidly cytolytic T lymphocytes in syngeneic mice, although they did elicit the production of more slowly cytotoxic cells. They were, however, susceptible to attack by cytolytic T cells from allo-immune mice and, if infected with ectro...

journal_title：Cancer letters

authors： Nelson DS,Hopper KE,Blanden RV,Gardner ID,Kearney R

更新日期：1978-08-01 00:00:00

abstract：:Human promyelocytic leukemia cells (HL-60) were found to be induced by dimethylsulfoxide and several other compounds to phagocytize, reduce NBT dye, and change into forms that were morphologically similar to granulocytes and macrophages. Arginase also induced these differentiation-associated properties of the cells. T...

journal_title：Cancer letters

authors： Honma Y,Fujita Y,Okabe-Kado J,Kasukabe T,Hozumi M

更新日期：1980-10-01 00:00:00

abstract：:The tumorigenicity of 4-aminobiphenyl (4-ABP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in combination with caloric restriction in the male neonatal CD1 mouse bioassay. 4-ABP and PhIP exhibited moderate and weak tumorigenicity, respectively, in ad libitum fed mice; however, none of the ca...

journal_title：Cancer letters

authors： Von Tungeln LS,Bucci TJ,Hart RW,Kadlubar FF,Fu PP

更新日期：1996-07-12 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the pre...

journal_title：Cancer letters

authors： Lee TK,Poon RT,Man K,Guan XY,Ma S,Liu XB,Myers JN,Yuen AP

更新日期：2007-09-08 00:00:00

abstract：:We studied the influence of the vitamins retinol acetate, alpha-tocopherol acetate and thiamine chloride; the antioxidant sodium selenite and an inhibitor of polyamine biosynthesis, alpha-difluoromethylornithine, on the offspring of transplacental carcinogenesis by ethylnitrosourea in rats. Ethylnitrosourea was given ...

journal_title：Cancer letters

authors： Alexandrov VA,Bespalov VG,Boone CW,Kelloff GJ,Malone WF

更新日期：1991-11-01 00:00:00

abstract：:Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus. Groups of male rats were fed AIN-76A diet containing EA (4 g/kg), CRA (240 mg/kg), or a combination of EA and CRA (4 g/kg and 240 mg/...

journal_title：Cancer letters

authors： Daniel EM,Stoner GD

更新日期：1991-02-01 00:00:00

abstract：:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...

journal_title：Cancer letters

authors： Kleinjans JC,Pluijmen MH,Hageman GJ,Verhagen H

更新日期：1989-01-01 00:00:00

abstract：:Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with erbB2-overexpressing tumors. However, resistances to trastuzumab frequently occur, and novel strategies/agents are urgently needed to abrogate the resistant phenotype. Our current study expl...

journal_title：Cancer letters

authors： Huang X,Wang S,Lee CK,Yang X,Liu B

更新日期：2011-08-01 00:00:00

abstract：:We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a...

journal_title：Cancer letters

authors： Jiao L,Hassan MM,Bondy ML,Abbruzzese JL,Evans DB,Li D

更新日期：2007-01-08 00:00:00