Abstract:
:We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a significantly reduced risk when compared with those carrying the (312)Asp allele (OR=0.46, 95% confidence interval 0.24-0.88) (P for interaction=0.03). The (312)Asp-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Jiao L,Hassan MM,Bondy ML,Abbruzzese JL,Evans DB,Li Ddoi
10.1016/j.canlet.2005.12.026keywords:
subject
Has Abstractpub_date
2007-01-08 00:00:00pages
61-8issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(05)01095-5journal_volume
245pub_type
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