当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > An M(r) 7-kDa membrane protein overexpressed in human multidrug-resistant ovarian cancer cells.

An M(r) 7-kDa membrane protein overexpressed in human multidrug-resistant ovarian cancer cells.

Abstract：

:We have developed a monoclonal antibody (designated 1D7) which recognizes an M(r) 7-kDa plasma membrane protein overexpressed in ovarian MDR cancer cells. The expression of the M(r) 7-kDa protein in various human multidrug-resistant and drug-sensitive cell lines was analysed by Western blot and flow cytometry methods. The small molecular weight protein was overexpressed in the human ovarian carcinoma cell line, SKVLB which was selected for vinblastine resistance from SKOV3 cells and in OVCAR 4/ADR100 and OVCAR 4/VBL200 which were generated from NIH:OVCAR4 by stepwise selection against adriamycin and vinblastine, respectively. Only a minor amount of the M(r) 7-kDa protein was found in the parent cell line, SKOV3. It was not found in other drug-resistant human cell lines such as the vinblastine-resistant CEM cells (CEM/VLB300), the intrinsic MDR colon cell line HCT15 and the human MDR breast cancer cell line, MCF7/AdrVp. 1D7 specifically inhibited the proliferation of the resistant cells. Our results suggest that the expression of the M(r) 7-kDa protein on the plasma membrane of ovarian MDR cancer cells may be involved in a mechanism related to the proliferation of the drug resistant cancer cells.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Yang X,Pagé M

doi

10.1016/0304-3835(94)03634-u

subject

Has Abstract

pub_date

1995-01-27 00:00:00

pages

171-8

issue

2

eissn

0304-3835

issn

1872-7980

pii

030438359403634U

journal_volume

88

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Formation of nitroso compounds and mutagens from cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide by drug/nitrite interaction.

    abstract：:The formation of nitroso compounds and mutagens from 5 nitrogen-containing drugs (cinnarizine, ethambutol, piromidic acid, pyridinol carbamate and tiaramide) by drug/nitrite interaction was examined. On the reaction of 50 micrometers drug and 500 micrometers nitrite at pH 3.0--3.4 and 37 degrees C for 4 h, the conside...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90075-1

    authors： Takeda Y,Kanaya H

    更新日期：1982-01-01 00:00:00

  • The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells.

    abstract：:The human myelocytic leukemia cell line HL-60 is a useful model for the study of cellular differentiation. Phorbol 12-myristate 13-acetate (PMA) induces the monocyte/macrophage-like differentiation of HL-60 cells and results in growth arrest, increasing adherence. In PMA-induced differentiation of HL-60 cells, phospho...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00505-5

    authors： Kim MS,Lim WK,Cha JG,An NH,Yoo SJ,Park JH,Kim HM,Lee YM

    更新日期：2001-09-28 00:00:00

  • CD133-induced TM4SF5 expression promotes sphere growth via recruitment and blocking of protein tyrosine phosphatase receptor type F (PTPRF).

    abstract：:CD133 is a surface marker of liver cancer stem cells. Transmembrane 4 L six family member 5 (TM4SF5) promotes sphere growth and circulation. However, it is unknown how CD133 and TM4SF5 cross-talk with each other for cancer stem cell properties. Here, we investigated the significance of inter-relationships between CD13...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.09.009

    authors： Kim S,Cho CY,Lee D,Song DG,Kim HJ,Jung JW,Kim JE,Park D,Lee H,Um H,Park J,Choi Y,Kim Y,Nam SH,Lee JW

    更新日期：2018-12-01 00:00:00

  • Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma.

    abstract：:We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA (shRNA) human kinase library. CellTiter 96(R)AQueous One Solution Cell Proliferation Assay was used to measure cell growth and survival. We identified several kinases, inc...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2010.01.014

    authors： Duan Z,Ji D,Weinstein EJ,Liu X,Susa M,Choy E,Yang C,Mankin H,Hornicek FJ

    更新日期：2010-07-28 00:00:00

  • BARD1 splice variants display mislocalization in breast cancer cells and can alter the apoptotic response to cisplatin.

    abstract：:We previously showed that BARD1 is a shuttling protein with pro-apoptotic activity in MCF-7 breast cancer cells. BARD1 is expressed as splice variant isoforms in breast cancer. Here we characterized YFP-tagged BARD1 splice variants (beta, omega, phi, ΔRIN, epsilon) for subcellular localization and apoptotic efficacy. ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.07.034

    authors： Marzec KA,Martino-Echarri E,Irminger-Finger I,Henderson BR

    更新日期：2016-10-10 00:00:00

  • Inhibitory effect of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid, on azoxymethane-induced intestinal carcinogenesis in rats.

    abstract：:Modifying effects of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid (KYN-54), on intestinal carcinogenesis were examined in a rat model using azoxymethane (AOM). A total of ninety male F344 rats, 6 weeks old, were divided into 4 groups. Group 1 (20 rats) was fed a diet containing KYN-5...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(92)90220-p

    authors： Mori H,Yoshimi N,Sugie S,Tanaka T,Morishita Y,Jinlong G,Tamai Y,Torihara M,Yamahara J

    更新日期：1992-09-30 00:00:00

  • Binding of [14C] azaserine to DNA and protein in the rat and hamster.

    abstract：:The binding of [14C] azaserine or its metabolites to DNA and protein in the organs of rats and hamsters was determined at various time after treatment with [14C] azaserine. The specific activity of 14C labelling of DNA and protein was determined. Rat liver DNA and protein were most extensively labelled at 90 min post-...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90092-1

    authors： Zurlo J,Coon CI,Longnecker DS,Curphey TJ

    更新日期：1982-05-01 00:00:00

  • Suppression of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced DNA damage in rat colon after grapefruit juice intake.

    abstract：:The influence of grapefruit juice intake on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced colon DNA damage was examined using comet assay in F344 rats given 60 mg/kg of PhIP by gavage. F344 rats allowed free access to grapefruit juice for 5 days experienced clearly reduced DNA damage in the colon to a...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00109-x

    authors： Miyata M,Takano H,Takahashi K,Sasaki YF,Yamazoe Y

    更新日期：2002-09-08 00:00:00

  • Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib.

    abstract：:Human epidermal growth factor receptor 2 (HER2), a member of the HER family of tyrosine kinases and a binding partner of Heat shock protein 90 (Hsp90), is found amplifies in approximately 25% breast cancers. Treatment of HER2+ breast cancers has been greatly improved in recent years, but the accompanying upregulation ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.10.040

    authors： Huang W,Wu QD,Zhang M,Kong YL,Cao PR,Zheng W,Xu JH,Ye M

    更新日期：2015-01-28 00:00:00

  • P5 HER2/neu-derived peptide conjugated to liposomes containing MPL adjuvant as an effective prophylactic vaccine formulation for breast cancer.

    abstract：:Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based vaccine delivery system using P5 HER2/neu-der...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.09.016

    authors： Shariat S,Badiee A,Jalali SA,Mansourian M,Yazdani M,Mortazavi SA,Jaafari MR

    更新日期：2014-12-01 00:00:00

  • An improved CTC isolation scheme for pairing with downstream genomics: Demonstrating clinical utility in metastatic prostate, lung and pancreatic cancer.

    abstract：:Improvements in technologies to yield purer circulating tumor cells (CTCs) will enable a broader range of clinical applications. We have previously demonstrated the use of a commercially available cell-adhesion matrix (CAM) assay to capture invasive CTCs (iCTCs). To improve the purity of the isolated iCTCs, here we us...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.06.017

    authors： Premasekharan G,Gilbert E,Okimoto RA,Hamirani A,Lindquist KJ,Ngo VT,Roy R,Hough J,Edwards M,Paz R,Foye A,Sood R,Copren KA,Gubens M,Small EJ,Bivona TG,Collisson EA,Friedlander TW,Paris PL

    更新日期：2016-09-28 00:00:00

  • Anti-angiogenic activity of ursodeoxycholic acid and its derivatives.

    abstract：:Ursodeoxycholic acid (UDCA) and its derivatives were examined for anti-angiogenic activities by using the chick embryo chorioallantoic membrane (CAM) assay. The presence of UDCA or its derivatives inhibited angiogenesis in a dose-dependent manner; the dose required for half-maximal inhibition (ID50) was 4 microg per C...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)04604-1

    authors： Suh H,Jung EJ,Kim TH,Lee HY,Park YH,Kim KW

    更新日期：1997-02-26 00:00:00

  • Induced expression of B7-H4 on the surface of lung cancer cell by the tumor-associated macrophages: a potential mechanism of immune escape.

    abstract：:B7-homolog 4 (B7-H4), a recently identified homolog of B7.1/2 (CD80/86), has been described to exert co-stimulatory and immune regulatory functions. We investigated the expression and the functional activity of B7-H4 in lung cancer in vitro and in vivo. Although a lung cancer cell line constitutively expressed B7-H4 m...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.11.017

    authors： Chen C,Qu QX,Shen Y,Mu CY,Zhu YB,Zhang XG,Huang JA

    更新日期：2012-04-01 00:00:00

  • Oligonucleotide microarray expression analysis of genes whose expression is correlated with tumorigenic and non-tumorigenic phenotype of HeLa x human fibroblast hybrid cells.

    abstract：:In order to understand the differences and similarities between tumorigenic and non-tumorigenic HeLaxhuman fibroblast hybrids, gene expression profiles were examined with synthetic oligonucleotide arrays containing nearly 7000 gene probe sets. We used two pairs of genetically related hybrids, each pair representing in...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00437-2

    authors： Nishizuka S,Winokur ST,Simon M,Martin J,Tsujimoto H,Stanbridge EJ

    更新日期：2001-04-26 00:00:00

  • Metabolic tumor burden: a new promising way to reach precise personalized therapy in PDAC.

    abstract：:Pancreatic cancer is currently one of the deadliest solid malignancies and pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. In the past decade, diagnostics and surgical techniques for PDAC have been evolving steadily; however, clinical outcomes of patients with PDAC have shown litt...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2015.01.023

    authors： Xiang J,Liu L,Wang W,Xu H,Wu C,Xu J,Liu C,Long J,Ni Q,Yu X

    更新日期：2015-04-10 00:00:00

  • Histone deacetylase inhibitors prevent activation of tumour-reactive NK cells and T cells but do not interfere with their cytolytic effector functions.

    abstract：:Histone deacetylase inhibitors (HDIs) exert direct tumour-toxic activity and sensitise tumour cells for other therapeutic regimens as well as the cytotoxic effects of activated immune cells. However, the HDI suberoylanilide hydroxamic acid (SAHA; vorinostat) interfered with the IL-2 activation of human NK cells and th...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2010.02.024

    authors： Schmudde M,Friebe E,Sonnemann J,Beck JF,Bröker BM

    更新日期：2010-09-28 00:00:00

  • Reactive oxygen species-independent G1 arrest induced by evening primrose extract in Ehrlich ascites tumor cells.

    abstract：:We previously demonstrated that evening primrose extract (EPE) induced apoptosis in Ehrlich ascites tumor cells (EATC), and this effect was specific on tumor cells. Furthermore, our results demonstrated that EPE exposure elicited a rapid increase in the activity of superoxide dismutase and intracellular peroxides leve...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2003.11.001

    authors： Arimura T,Kojima-Yuasa A,Kennedy DO,Matsui-Yuasa I

    更新日期：2004-04-15 00:00:00

  • MELK is an oncogenic kinase essential for early hepatocellular carcinoma recurrence.

    abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Many kinases have been found to be intimately involved in oncogenesis and the deregulation of kinase function has emerged as a major mechanism by which cancer cells evade normal physiological constraints on growth and surviv...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.09.017

    authors： Xia H,Kong SN,Chen J,Shi M,Sekar K,Seshachalam VP,Rajasekaran M,Goh BKP,Ooi LL,Hui KM

    更新日期：2016-12-01 00:00:00

  • alpha-Toxin of Staphylococcus aureus overcomes acquired cisplatin-resistance in malignant mesothelioma cells.

    abstract：:alpha-Toxin (alpha-hemolysin) of Staphylococcus aureus is a pore-forming bacterial toxin which after caveolin-1-dependent assembly induces apoptosis in eukaryotic cells. We investigated if a sub-toxic concentration of staphylococcal alpha-toxin could enhance cisplatin-induced apoptosis and overcome acquired cisplatin-...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.02.007

    authors： Johansson D,Johansson A,Behnam-Motlagh P

    更新日期：2008-06-28 00:00:00

  • Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells.

    abstract：:The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated MDR, synthetic peptides cor...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.04.001

    authors： Gatouillat G,Odot J,Balasse E,Nicolau C,Tosi PF,Hickman DT,López-Deber MP,Madoulet C

    更新日期：2007-11-18 00:00:00

  • DNA adducts in tissues of germ-free and conventional rats fed high- and low-esterified pectins.

    abstract：:Tissue samples from germ-free and conventional rats fed pectins with different degrees of esterification (DE) were tested for containing indigenous DNA adducts (I-compounds). For 21 days groups of six germ-free and 10 conventional rats each were fed either pectin-free or with diets containing 7.5% of three differently...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)04621-1

    authors： Zunft HJ,Goldin-Lang P,Dongowski G

    更新日期：1997-03-19 00:00:00

  • Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray.

    abstract：:The 5-Fluorouracil (5-FU) is an anticancer drug that is widely used in the treatment of cancer. To identify novel genes associated with 5-FU in gastric cancer, the time-dependent expression profiling of genes in response to 5-FU was examined in 5-FU sensitive and/or resistant gastric cancer cell lines using a 'KUGI 14...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.04.012

    authors： Park JS,Young Yoon S,Kim JM,Yeom YI,Kim YS,Kim NS

    更新日期：2004-10-08 00:00:00

  • ShRNA-based POLD2 expression knockdown sensitizes glioblastoma to DNA-Damaging therapeutics.

    abstract：:Glioblastoma (GBM) has limited therapeutic options. DNA repair mechanisms contribute GBM cells to escape therapies and re-establish tumor growth. Multiple studies have shown that POLD2 plays a critical role in DNA replication, DNA repair and genomic stability. We demonstrate for the first time that POLD2 is highly exp...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.01.011

    authors： Xu Q,Hu C,Zhu Y,Wang K,Lal B,Li L,Tang J,Wei S,Huang G,Xia S,Lv S,Laterra J,Jiang Y,Li Y

    更新日期：2020-07-10 00:00:00

  • Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells.

    abstract：:Pancreatic cancer is an aggressive malignancy and unresponsive to conventional chemotherapies. Here, the anti-inflammatory and anti-tumor effects of embelin on pancreatic cancer were investigated. Embelin significantly attenuated cells invasion, proliferation and induced apoptosis through inhibition of STAT3 and activ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.08.011

    authors： Peng M,Huang B,Zhang Q,Fu S,Wang D,Cheng X,Wu X,Xue Z,Zhang L,Zhang D,Da Y,Dai Y,Yang Q,Yao Z,Qiao L,Zhang R

    更新日期：2014-11-28 00:00:00

  • Depletion of end-binding protein 1 (EB1) promotes apoptosis of human non-small-cell lung cancer cells via reactive oxygen species and Bax-mediated mitochondrial dysfunction.

    abstract：:Although end-binding protein 1 (EB1) is well known to regulate microtubule dynamics, the role of EB1 in apoptosis of non-small cell lung cancer (NSCLC) is poorly understood. Here, we investigated the molecular mechanism by which EB1 regulates apoptosis in H460, A549, and H1299 cells. Depletion of EB1 in A549 and H1299...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.07.027

    authors： Kim MJ,Yun HS,Hong EH,Lee SJ,Baek JH,Lee CW,Yim JH,Kim JS,Park JK,Um HD,Hwang SG

    更新日期：2013-10-01 00:00:00

  • C-type virus particles in the transplantable mouse bladder tumour FCB grown in vitro.

    abstract：:Electron microscopic studies were made on an in vitro cultured cell line obtained from the FCB transplantable murine bladder tumour. The cells exhibited a loss of differentiation compared with solid tumour and the presence of C-type virus particles, many in the process of budding. The possible relation of this virus t...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(77)94211-2

    authors： Flaks A

    更新日期：1977-07-01 00:00:00

  • Long non-coding RNAs in glioma progression.

    abstract：:Glioma is one of most malignant primary tumors of the brain. However, due to a lack of effective means for diagnosing and treating glioma, the prognosis of glioma patients remains poor. Therefore, understanding the molecular mechanism of glioma progression is essential for effective treatment. Long non-coding RNAs (ln...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2018.01.041

    authors： Xi J,Sun Q,Ma L,Kang J

    更新日期：2018-04-10 00:00:00

  • The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis.

    abstract：:Third generation bisphosphonates (BPs), including YM175 and YM529, are known to inhibit bone resorption. The aim of this study was to evaluate the anti-tumor effects of these drugs on murine osteosarcoma cell lines, in terms of proliferation and apoptosis. We found that both YM175 and YM529 strongly inhibited the in v...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.06.041

    authors： Horie N,Murata H,Nishigaki Y,Matsui T,Segawa H,Nogawa M,Yuasa T,Kimura S,Maekawa T,Fushiki S,Kubo T

    更新日期：2006-07-08 00:00:00

  • Stress kinase signaling in cancer: fact or fiction?

    abstract：:Cancer results from genetic alterations in intracellular signaling pathways, which normally orchestrate the execution of developmental programs and the organismic response to extrinsic factors. Mutations in upstream activators and components of the cytoplasmic (Ras-Raf MEK-ERK) cascade frequently occur in tumors. In v...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2004.08.003

    authors： Rennefahrt U,Janakiraman M,Ollinger R,Troppmair J

    更新日期：2005-01-10 00:00:00

  • Genetic damage and the inhibition of 7,12-dimethylbenz[a]anthracene-induced genetic damage by the phytoestrogens, genistein and daidzein, in female ICR mice.

    abstract：:Populations consuming soybeans have reduced rates of breast, colon and prostate cancer possibly due, in part, to the presence in soybeans of two estrogenic isoflavones, genistein and daidzein. This study investigated the genotoxicity of these soya isoflavones and their interactions with 7,12-dimethylbenz[a]anthracene ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03877-y

    authors： Giri AK,Lu LJ

    更新日期：1995-08-16 00:00:00