当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma.

Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma.

Abstract：

:Oral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the precise roles of Fascin in OSCC have not been elucidated clearly. The aim of this study was to analyze the roles of Fascin in OSCC progression using OSCC clinical samples. We demonstrated that Fascin over-expression was found in OSCC clinical samples and its expression was significantly associated with nodal metastasis (p=0.027), tumor recurrence (p<0.001) and poor patients' overall survival (p=0.013). Consistently, Fascin proteins were detected in all OSCC cell lines with the expression level corresponding to the invasion ability. To specifically investigate the mechanism of Fascin in OSCC, we examined the E-cadherin expression in the same set of OSCC specimens. Fascin was negatively correlated with E-cadherin expression (p=0.018, r=-0.513). In conclusion, our findings suggested that Fascin over-expression might enhance OSCC aggressiveness, possibly by interacting with E-cadherin expression.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Lee TK,Poon RT,Man K,Guan XY,Ma S,Liu XB,Myers JN,Yuen AP

doi

10.1016/j.canlet.2007.03.017

subject

Has Abstract

pub_date

2007-09-08 00:00:00

pages

308-15

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(07)00150-4

journal_volume

254

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Inhibition of azoxymethane-induced intestinal cancer by disulfiram.

    abstract：:Sprague--Dawley rats, both intact and colostomized animals, were given 24 weekly injections of azoxymethane. Rats were fed either Rat Purina Chow or the same diet plus 0.25% disulfiram. In the intact animals, disulfiram reduced tumors from an average of 6.3 to 0.95. The number of rats developing tumors was reduced fro...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(78)80050-0

    authors： Nigro ND,Campbell RL

    更新日期：1978-08-01 00:00:00

  • Feasibility of using lower doses of chemopreventive agents in a combination regimen for cancer protection.

    abstract：:In experimental cancer chemoprevention studies, the doses of the agent used to produce an inhibitory response are generally very high, sometimes bordering on levels that will result in toxicity to the test animals. The present study was designed to test the hypothesis that low doses of two or more agents may be just a...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90066-3

    authors： Ip C

    更新日期：1988-04-01 00:00:00

  • Loss of histone lysine methyltransferase EZH2 confers resistance to tyrosine kinase inhibitors in non-small cell lung cancer.

    abstract：:Tyrosine kinase inhibitor (TKI) treatment is the first-line therapy for non-small cell lung cancer (NSCLC) caused by activating mutations of epidermal growth factor receptor (EGFR). However, acquired resistance to EGFR-TKI occurs almost inevitably. Aberrant activation of proto-oncogene MET has been known to confer EGF...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.09.003

    authors： Quan C,Chen Y,Wang X,Yang D,Wang Q,Huang Y,Petersen RB,Liu X,Zheng L,Li Y,Huang K

    更新日期：2020-12-28 00:00:00

  • Oxidative DNA base damage in cancerous tissues of patients undergoing brachytherapy.

    abstract：:This aim of this study was to measure the typical free radical-induced products of DNA bases in cellular DNA of cervical cancer tissues directly irradiated by applying brachytherapy to the patients. Significant increases in the amounts of modified bases over the control level were observed in the samples isolated afte...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00170-0

    authors： Foksinski M,Jaruga P,Makarewicz R,Olinski R

    更新日期：1998-10-23 00:00:00

  • BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition.

    abstract：:Transcriptional factor BTB and CNC homology 1 (Bach1) has been linked to tumor progression and metastasis, but the mechanisms underlying the effects of Bach1 on tumor growth and metastasis are largely uncharacterized. Here, we report that Bach1 expression was significantly higher in human epithelial ovarian cancer (EO...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.01.003

    authors： Han W,Zhang Y,Niu C,Guo J,Li J,Wei X,Jia M,Zhi X,Yao L,Meng D

    更新日期：2019-03-31 00:00:00

  • Erufosine simultaneously induces apoptosis and autophagy by modulating the Akt-mTOR signaling pathway in oral squamous cell carcinoma.

    abstract：:We investigated the anticancer activity of erufosine in oral squamous carcinoma cell lines in terms of cell proliferation, colony formation, induction of autophagy/apoptosis, cell cycle and mTOR signaling pathway. Erufosine showed dose-dependent cytotoxicity in all cell lines, it induced autophagy as well as apoptosis...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.12.032

    authors： Kapoor V,Zaharieva MM,Das SN,Berger MR

    更新日期：2012-06-01 00:00:00

  • Alkali-labile sites are prevalent in kidney tissue DNA.

    abstract：:Inherent DNA damage in the form of single strand breaks and alkali labile sites is generated by essential intracellular processes, such as DNA replication and repair. Utilizing the in situ DNA unwinding assay and the comet assay (single cell gel), we have observed high levels of alkali induced DNA strand breaks in cel...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90166-x

    authors： Fairbairn DW,Reyes WA,O'Neill KL

    更新日期：1994-06-15 00:00:00

  • AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.

    abstract：:SIRT2, a member of the sirtuin family, is involved in the regulation of a variety of physiological functions. In addition, SIRT2 has been studied in the context of pathological conditions including neurodegenerative diseases, metabolic syndrome, and cancer. The effect of SIRT2 on cancer cell growth depends on cancer t...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.10.012

    authors： Cheon MG,Kim W,Choi M,Kim JE

    更新日期：2015-01-28 00:00:00

  • Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma.

    abstract：:We describe an optimized systematic screen of known kinases using osteosarcoma cell lines (KHOS and U-2OS) and a lentiviral-based short hairpin RNA (shRNA) human kinase library. CellTiter 96(R)AQueous One Solution Cell Proliferation Assay was used to measure cell growth and survival. We identified several kinases, inc...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2010.01.014

    authors： Duan Z,Ji D,Weinstein EJ,Liu X,Susa M,Choy E,Yang C,Mankin H,Hornicek FJ

    更新日期：2010-07-28 00:00:00

  • Highlights in experimental therapeutics.

    abstract：:The past two decades have seen a dramatic change in cancer treatment paradigms. Anticancer agents are no longer being developed based on empiricism and serendipity, but are now being aimed to inhibit a validated target that is relatively specific for tumours rather than normal cells. The vast majority of cancers arise...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2006.03.012

    authors： Burger AM

    更新日期：2007-01-08 00:00:00

  • Inhibitory activity of chlorophyllin on the genotoxicity of carcinogens in Drosophila.

    abstract：:Antimutagenic activity of copper chlorophyllin against various carcinogenic mutagens was assayed with Drosophila genotoxicity tests, i.e., the wing spot test for detecting somatic cell mutations and the DNA repair test for detecting DNA damage. In these tests, Drosophila larvae were fed carcinogens together with chlor...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90313-1

    authors： Negishi T,Nakano H,Kitamura A,Itome C,Shiotani T,Hayatsu H

    更新日期：1994-08-15 00:00:00

  • Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis.

    abstract：:Castration is the standard therapeutic treatment for advanced prostate cancer but with limited benefit due to the profound relapse and metastasis. Activation of inflammatory signaling pathway and initiation of epithelial-mesenchymal transition (EMT) are closely related to drug resistance, tumor relapseas well as metas...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.12.031

    authors： Tong D,Liu Q,Liu G,Xu J,Lan W,Jiang Y,Xiao H,Zhang D,Jiang J

    更新日期：2017-03-28 00:00:00

  • In vivo formation of DNA-adducts in mouse skin DNA by tamoxifen.

    abstract：:Tamoxifen (TAM)-induced DNA adduct formation in mouse skin was determined by a nuclease P1-enhanced 32P-postlabelling technique. Topical application of TAM significantly induced a number of DNA-adducts in mouse skin in a dose- and time-dependent manner. When SENCAR mice were topically treated with different doses of T...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(95)03802-4

    authors： Cai Q,Wei H

    更新日期：1995-06-08 00:00:00

  • Metronomic chemotherapy in metastatic colorectal cancer.

    abstract：:Overall survival and quality of life of patients with metastatic colorectal cancer (mCRC) have improved due to the development of standard systemic treatment. However, many patients are still suffering from the eventual progression of cancer, treatment-related toxicities, and the economic burden of new drugs. Salvage ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2017.02.034

    authors： Woo IS,Jung YH

    更新日期：2017-08-01 00:00:00

  • Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells.

    abstract：:Microtubule targeting based therapies have revolutionized cancer treatment; however, resistance and side effects remain a major limitation. Therefore, novel strategies that can overcome these limitations are urgently needed. We made a novel discovery that fisetin, a hydroxyflavone, is a microtubule stabilizing agent. ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.07.030

    authors： Mukhtar E,Adhami VM,Sechi M,Mukhtar H

    更新日期：2015-10-28 00:00:00

  • Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families.

    abstract：:Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present s...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.05.043

    authors： Frank B,Burwinkel B,Bermejo JL,Försti A,Hemminki K,Houlston R,Mangold E,Rahner N,Friedl W,Friedrichs N,Buettner R,Engel C,Loeffler M,Holinski-Feder E,Morak M,Keller G,Schackert HK,Krüger S,Goecke T,Moeslein G,Kloo

    更新日期：2008-11-18 00:00:00

  • Aiming at the sweet side of cancer: aberrant glycosylation as possible target for personalized-medicine.

    abstract：:One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often lead...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2013.10.005

    authors： Padler-Karavani V

    更新日期：2014-09-28 00:00:00

  • Adipocytokines visfatin and resistin in breast cancer: Clinical relevance, biological mechanisms, and therapeutic potential.

    abstract：:Obesity is one of the major modifiable risk factors in breast cancer, with obese adipose tissue showing a pathological role in breast cancer development and malignancy via the release of secretory factors, such as proinflammatory cytokines and adipocytokines. The current article focuses on visfatin and resistin, two s...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.10.045

    authors： Wang YY,Hung AC,Lo S,Yuan SF

    更新日期：2021-02-01 00:00:00

  • Trabectedin overcomes doxorubicin-resistance, counteracts tumor-immunosuppressive reprogramming of monocytes and decreases xenograft growth in Hodgkin lymphoma.

    abstract：:Classical Hodgkin lymphoma (cHL) tumor cells are surrounded by a protective tumor microenvironment (TME). Trabectedin, an anticancer drug targeting both tumor cells and TME, demonstrated a potent antitumor activity against Hodgkin Reed Sternberg (HRS) cells. It was cytotoxic against cHL cell lines, including the doxor...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.12.015

    authors： Casagrande N,Borghese C,Favero A,Vicenzetto C,Aldinucci D

    更新日期：2021-03-01 00:00:00

  • Resistance factors in colon cancer tissue and the adjacent normal colon tissue: glutathione S-transferases alpha and pi, glutathione and aldehyde dehydrogenase.

    abstract：:Glutathione S-transferases (GST) alpha and pi, glutathione (GSH) and aldehyde dehydrogenase (ADH) were determined in colorectal cancer tissue specimens and in the adjacent normal colon tissue. The median contents in normal and cancer tissue were 8.1 (2.3-30.3) (5-95% quantiles) and 15.1 (5.3-50.3) microg/mg protein fo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00059-7

    authors： Hengstler JG,Böttger T,Tanner B,Dietrich B,Henrich M,Knapstein PG,Junginger T,Oesch F

    更新日期：1998-06-05 00:00:00

  • Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer.

    abstract：:Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma and some other solid tumors. However, the direct functional mechanisms of tumor lethality mediated by apatinib have not yet been fully characterized, and the precise mechanis...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.05.046

    authors： Cheng X,Feng H,Wu H,Jin Z,Shen X,Kuang J,Huo Z,Chen X,Gao H,Ye F,Ji X,Jing X,Zhang Y,Zhang T,Qiu W,Zhao R

    更新日期：2018-09-01 00:00:00

  • Effects of eicosanoid metabolism inhibitors on growth of a human gastric tumour cell line (HGT).

    abstract：:HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90189-g

    authors： Denizot Y,Najid A,Rigaud M

    更新日期：1993-09-15 00:00:00

  • Overexpression of DLC-1 induces cell apoptosis and proliferation inhibition in the renal cell carcinoma.

    abstract：:The lack of effective anti-tumor therapy for renal cell carcinoma (RCC) has stimulated the search for novel target whose inhibition could block tumorigenesis. Recently, reduced DLC-1 has been shown to be associated with aggressive and highly metastatic renal cell carcinoma. In this study, the biological role of DLC-1 ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.03.025

    authors： Zhang T,Zheng J,Jiang N,Wang G,Shi Q,Liu C,Lu Y

    更新日期：2009-09-28 00:00:00

  • The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis.

    abstract：:Third generation bisphosphonates (BPs), including YM175 and YM529, are known to inhibit bone resorption. The aim of this study was to evaluate the anti-tumor effects of these drugs on murine osteosarcoma cell lines, in terms of proliferation and apoptosis. We found that both YM175 and YM529 strongly inhibited the in v...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.06.041

    authors： Horie N,Murata H,Nishigaki Y,Matsui T,Segawa H,Nogawa M,Yuasa T,Kimura S,Maekawa T,Fushiki S,Kubo T

    更新日期：2006-07-08 00:00:00

  • NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.

    abstract：:Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett's tumorigenesis. In this study, we investigated the role of NRF2 in response to exposure to acidic bile salts (ABS), in conditions that mimic GERD, using Barrett's esophagus cell models. We detected an increase in NRF2 protein levels, following...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.05.031

    authors： Peng D,Lu H,Zhu S,Zhou Z,Hu T,Chen Z,Zaika A,El-Rifai W

    更新日期：2019-08-28 00:00:00

  • Emerging roles of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in cancer progression.

    abstract：:The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid -directed processes. Recently, this protein has emerged as an important player in carcinogenesis process. HnRNP K is overexpressed in several hum...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.06.019

    authors： Barboro P,Ferrari N,Balbi C

    更新日期：2014-10-01 00:00:00

  • Fetal fetuin selectively induces apoptosis in cancer cell lines and shows anti-cancer activity in tumor animal models.

    abstract：:An apoptosis-inducing protein with molecular weight of 60 kDa has been purified from fetal bovine serum. The N-terminal amino acid sequence of this protein (e.g. I-P-L-D-P-V-A-G-Y-K) reveals that it is bovine fetuin, a fetal protein functioning to control embryogenesis. The apoptosis-inducing activity of fetuin is tot...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00417-7

    authors： Yu CL,Tsai MH

    更新日期：2001-05-26 00:00:00

  • Targeting Hsp70: A possible therapy for cancer.

    abstract：:In all organisms, heat-shock proteins (HSPs) provide an ancient defense system. These proteins act as molecular chaperones by assisting proper folding and refolding of misfolded proteins and aid in the elimination of old and damaged cells. HSPs include Hsp100, Hsp90, Hsp70, Hsp40, and small HSPs. Through its substrate...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2016.01.056

    authors： Kumar S,Stokes J 3rd,Singh UP,Scissum Gunn K,Acharya A,Manne U,Mishra M

    更新日期：2016-04-28 00:00:00

  • Chemoprotection by sulforaphane: keep one eye beyond Keap1.

    abstract：:Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, with particularly high levels detected in broccoli and broccoli sprouts. Over a decade ago, this phytochemical was identified as a likely chemopreventive agent based on its ability to induce Phase 2 detoxification enzymes, as well as to inhibit P...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2005.02.033

    authors： Myzak MC,Dashwood RH

    更新日期：2006-02-28 00:00:00

  • Determination of cytotoxicity in vivo using 111indium-labeled human tumor cells.

    abstract：:Loss of radioactivity from nude mice was determined after inoculation of human tumor cells prelabeled with [111In]indium oxine (111InOx). Elimination of 111In was increased somewhat by treating the mice with diphtheria toxin (DT), which is toxic selectively for human cells compared to mice. Calcium disodium edetate (C...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(84)90134-4

    authors： Lockshin A,Giovanella BC,Kozielski T,Stehlin JS Jr

    更新日期：1984-09-01 00:00:00