当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > p53 Codon 72 polymorphism and urothelial cancer risk.

p53 Codon 72 polymorphism and urothelial cancer risk.

Abstract：

:The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases and 175 male unrelated non-cancer controls. The allelic frequencies in Japanese non-cancer controls were 0.58 (Arg) and 0.42 (Pro). There was no significant difference in the three genotype frequencies (Arg/Arg, Arg/Pro, Pro/Pro) of the p53 codon 72 between the urothelial cancer cases and the controls. However, stratifying by smoking status, we found that the frequency of the Pro/Pro genotype for smokers was significantly more than that for never-smokers (odds ratio (OR)=2.28, 95% confidence interval (95%CI)=1.12-4.66). Furthermore, we divided smoking status (pack-years) into quartiles (<20, 20-40, 40-60, >60). OR (Pro/Pro vs. Arg/Arg) for the lighter smokers (<20 pack-years) was higher than in other groups (OR=6.83). Our results suggest that the Pro/Pro genotype of the p53 codon 72 polymorphism increases the risk of urothelial cancer in smokers.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Kuroda Y,Tsukino H,Nakao H,Imai H,Katoh T

doi

10.1016/s0304-3835(02)00518-9

keywords:

subject

Has Abstract

pub_date

2003-01-10 00:00:00

pages

77-83

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304383502005189

journal_volume

189

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Decreased cytosolic levels of the heme binding Z protein in rat hepatocyte nodules and hepatocellular carcinomas.

    abstract：:Hepatocyte nodules and hepatocellular carcinomas were induced in male Fischer rats using the resistant hepatocyte model. The immunoreactive cytosolic levels of the heme-binding Z protein (HBP) were reduced by 56% (P less than 0.001; 2-tailed t-test) in early hepatocyte nodules (25 weeks) and hepatocellular carcinomas ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90213-3

    authors： Roomi MW,Vincent SH,Farber E,Muller-Eberhard U

    更新日期：1988-12-01 00:00:00

  • Antimutagenic activity of anthocyanins isolated from Aronia melanocarpa fruits.

    abstract：:Anthocyanins belong to the flavonoid family and are ubiquitous in plants, especially in flower petals and fruit peels. We established that anthocyanins isolated from fruits of Aronia melanocarpa markedly inhibited the mutagenic activity of benzo(a)pyrene and 2-amino fluorene in the Ames test. In the Sister Chromatid E...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00248-6

    authors： Gasiorowski K,Szyba K,Brokos B,Kołaczyńska B,Jankowiak-Włodarczyk M,Oszmiański J

    更新日期：1997-10-28 00:00:00

  • Activation of signal transduction pathways during hepatic oncogenesis.

    abstract：BACKGROUND AND AIMS:Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. METHODS:Liver specific expression of HBV X protein (HBx) and insulin receptor substrate 1 (IRS1) w...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.09.016

    authors： Chung W,Kim M,de la Monte S,Longato L,Carlson R,Slagle BL,Dong X,Wands JR

    更新日期：2016-01-01 00:00:00

  • Stimulation of cultured colon 26 cells with TNF-alpha promotes lung metastasis through the extracellular signal-regulated kinase pathway.

    abstract：:We investigated the influence of TNF-alpha on the metastasis of cancer cells. Treatment of cultured colon 26 cells with TNF-alpha enhanced metastatic properties including production of MMP-9, adhesion, migration and invasion. Cells treated with TNF-alpha in vitro showed marked potential to metastasize to the lung and ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.12.027

    authors： Choo MK,Sakurai H,Koizumi K,Saiki I

    更新日期：2005-12-08 00:00:00

  • A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.

    abstract：:In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer c...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.01.022

    authors： Suh YA,Kim JH,Sung MA,Boo HJ,Yun HJ,Lee SH,Lee HJ,Min HY,Suh YG,Kim KW,Lee HY

    更新日期：2013-05-10 00:00:00

  • Determination of DNA topoisomerase II in newly diagnosed childhood acute lymphoblastic leukemia by immunocytochemistry and RT-PCR.

    abstract：:The expression of DNA-topoisomerase II was analysed at the protein level in newly diagnosed cases of acute lymphoblastic leukemia (ALL) in children. Blast cells obtained from 81 children with untreated ALL were determined by means of immunocytochemistry. Of the ALL, 49 (60%) were positive for topoisomerase II and 32 (...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90368-9

    authors： Stammler G,Sauerbrey A,Volm M

    更新日期：1994-09-15 00:00:00

  • Different ras gene mutational frequencies in thyroid papillary carcinomas in Japan and Thailand.

    abstract：:The incidence and pattern of ras oncogene mutations in human malignancies demonstrate geographic and racial differences. For example, specificity of alterations is found in cholangiocellular carcinomas in Thai patients with a different etiology from those in Japanese patients. In the present study, a comparison of ras...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00149-9

    authors： Naito H,Pairojkul C,Kitahori Y,Yane K,Miyahara H,Konishi N,Matsunaga T,Hiasa Y

    更新日期：1998-09-25 00:00:00

  • Tumoricidal bystander effect in the suicide gene therapy using mesenchymal stem cells does not injure normal brain tissues.

    abstract：:In our previous rat study, an established intracranial C6 glioma was successfully treated using intratumoral injection of mesenchymal stem cells transduced with the herpes simplex virus-thymidine kinase gene (MSCtk) and systemic administration of ganciclovir (GCV). In the present study, effect of the "bystander effect...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.02.037

    authors： Amano S,Gu C,Koizumi S,Tokuyama T,Namba H

    更新日期：2011-07-01 00:00:00

  • Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome.

    abstract：INTRODUCTION/HYPOTHESIS:Over-expression of the c-Met receptor tyrosine kinase has been described in a variety of cancers and implicated in tumor progression. Unlike some solid tumors, current evidence indicates that c-Met activation in colon cancer is unrelated to gene mutation, is ligand dependent, and occurs via a pa...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2006.07.007

    authors： Kammula US,Kuntz EJ,Francone TD,Zeng Z,Shia J,Landmann RG,Paty PB,Weiser MR

    更新日期：2007-04-18 00:00:00

  • Synergistic inhibitory effects of transplatin and beta-hydroxyisovalerylshikon on carcinoma A431 cells involve epidermal growth factor receptor.

    abstract：:Treatment of human epidermoid carcinoma A431 cells with transplatin (trans-DDP) and beta-hydroxyisovalerylshikon (beta-HIVS) together had a strong inhibitory effect on A431 cells. By contrast, trans-DDP and beta-HIVS by themselves, at the same respective concentrations, had practically no effect. The tyrosine kinase a...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00457-3

    authors： Xu Y,Nakajo S,Nakaya K

    更新日期：2002-12-15 00:00:00

  • Identification and analysis of CD133(+) melanoma stem-like cells conferring resistance to taxol: An insight into the mechanisms of their resistance and response.

    abstract：:The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.09.024

    authors： El-Khattouti A,Selimovic D,Haïkel Y,Megahed M,Gomez CR,Hassan M

    更新日期：2014-02-01 00:00:00

  • HA14-1 sensitizes TNF-alpha-induced apoptosis via inhibition of the NF-kappaB signaling pathway: involvement of reactive oxygen species and JNK.

    abstract：:Nuclear factor-kappa B (NF-kappaB) activation by tumor necrosis factor-alpha (TNF-alpha) attenuates the TNF-alpha-induced apoptosis pathway. Thus, blockage of NF-kappaB activity may improve the anti-cancer activity of TNF-alpha. HA14-1 induces apoptosis in various human cancer cells, and the molecular mechanisms of th...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.11.014

    authors： Moon DO,Kim MO,Kang SH,Choi YH,Park SY,Kim GY

    更新日期：2010-06-01 00:00:00

  • The missense mutations in the candidate prostate cancer gene ELAC2 do not alter enzymatic properties of its product.

    abstract：:The candidate prostate cancer gene ELAC2 encodes tRNA 3' processing endoribonuclease (tRNase ZL). We produced recombinant human tRNase ZL's, which contain one to three amino-acid substitutions from three missense mutations (Ser217Leu, Ala541Thr, and Arg781His) that are associated with the occurrence of prostate cancer...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.09.013

    authors： Minagawa A,Takaku H,Takagi M,Nashimoto M

    更新日期：2005-05-26 00:00:00

  • Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS.

    abstract：:Parthanatos is a new form of programmed cell death that is regulated by hyper-activated PARP-1, and is emerging as a new strategy to kill cancer cells. Deoxypodophyllotoxin (DPT) is a natural chemical that is found to induce cancer cell death, in which the role of parthanatos is unknown. Thus, we investigated this iss...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.11.044

    authors： Ma D,Lu B,Feng C,Wang C,Wang Y,Luo T,Feng J,Jia H,Chi G,Luo Y,Ge P

    更新日期：2016-02-28 00:00:00

  • Genomic rearrangements in MSH2 and MLH1 are rare mutational events in Spanish patients with hereditary nonpolyposis colorectal cancer.

    abstract：:Colorectal cancer (CRC) is one of the most common neoplasms and a leading cause of death related to cancer worldwide. Hereditary nonpolyposis colorectal cancer (HNPCC) is the most frequent autosomal dominant predisposition to the development of CRC, accounting for approximately 2.5% of the total CRC burden in Spain. G...

    journal_title：Cancer letters

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.canlet.2005.01.036

    authors： Castellví-Bel S,Castells A,Strunk M,Ferrández A,Piazuelo E,Milà M,Piñol V,Rodríguez-Moranta F,Andreu M,Lanas A,Piqué JM,Gastrointestinal Oncology Group of the Spanish Gastroenterological Association.

    更新日期：2005-07-08 00:00:00

  • P5 HER2/neu-derived peptide conjugated to liposomes containing MPL adjuvant as an effective prophylactic vaccine formulation for breast cancer.

    abstract：:Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based vaccine delivery system using P5 HER2/neu-der...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.09.016

    authors： Shariat S,Badiee A,Jalali SA,Mansourian M,Yazdani M,Mortazavi SA,Jaafari MR

    更新日期：2014-12-01 00:00:00

  • Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice.

    abstract：:Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00171-2

    authors： Connolly JM,Rose DP

    更新日期：1998-10-23 00:00:00

  • Transplacental effect of diethylstilbestrol in female rats.

    abstract：:The effect of diethylstilbestrol propionate (DES; 1 mg/kg body wt. was studied in the female offspring of rats exposed subcutaneously on the 19th day of gestation. Examination of vaginal smears showed persistent estrus in adult rats treated prenatally with DES. Compensatory ovarian hypertrophy (COH) induced by hemicas...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(79)80008-7

    authors： Napalkov NP,Anisimov VN

    更新日期：1979-02-01 00:00:00

  • The origin and role of blood-borne monocytes in rats with a transplanted myelogenous leukaemia.

    abstract：:The growth of a transplantable myeloid leukaemia into its syngeneic host is accompanied by a progressive increase in the number of blood monocytes. These were shown to be of host origin and were not derived from the inoculated leukaemia cells. The host response which is responsible for the monocytosis differs from tha...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(75)94893-4

    authors： Gauci CL,Wrathmell A,Alexander P

    更新日期：1975-09-01 00:00:00

  • Toxoplasma gondii antibodies in cancer patients.

    abstract：:To determine Toxoplasma gondii antibodies in cancer patients, 267 cancer patients were studied using ELISA and higher positivity rates of T. gondii IgG were detected than the control. The positivity rates of T. gondii IgG in nasopharyngeal carcinoma, rectal cancer groups were significantly higher than the other cancer...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.02.011

    authors： Yuan Z,Gao S,Liu Q,Xia X,Liu X,Liu B,Hu R

    更新日期：2007-08-28 00:00:00

  • Melanoma-associated antigen genes - an update.

    abstract：:To date, dozens of melanoma-associated antigens (MAGE) have been identified. Based on the differences in tissue-specific gene expression and gene structure, the MAGE family has been divided into two big subfamilies: MAGE-I and MAGE-II. MAGE-I genes were identified as a group of highly attractive targets for cancer imm...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2010.10.021

    authors： Sang M,Wang L,Ding C,Zhou X,Wang B,Wang L,Lian Y,Shan B

    更新日期：2011-03-28 00:00:00

  • Human hepatocellular carcinoma: expression profiles-based molecular interpretations and clinical applications.

    abstract：:Primary liver cancer is the fifth most common cancer worldwide and hepatocellular carcinoma (HCC) accounts for over 85% of all primary liver cancers. The clinical management of advanced and metastatic HCC is challenging on many counts. Besides largely occurs within a background of underlying chronic liver disease and ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2008.11.005

    authors： Hui KM

    更新日期：2009-12-01 00:00:00

  • piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells.

    abstract：:Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the e...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.10.004

    authors： Cheng J,Deng H,Xiao B,Zhou H,Zhou F,Shen Z,Guo J

    更新日期：2012-02-01 00:00:00

  • Potent tumorigenicity of 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene in the neonatal B6C3F (1) male mouse.

    abstract：:The tumorigenicity of 7-chlorobenz[a]anthracene (7-Cl-BA, and environmental contaminant, and 7 bromobenz[a]anthracene (7-Br-BA) was determines in the male B6C3F(1) newborn mouse. Mice receiving 7-Cl-BA and 7-Br-BA by i.p. injections at a dose of 1600 nmol per mouse on 1, 8, and 15 days after birth developed 92 and 96%...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(96)04111-0

    authors： Fu PP,Von Tungeln LS,Zhan DJ,Bucci T

    更新日期：1996-03-19 00:00:00

  • A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53.

    abstract：:Targeting specific tumor metabolic needs represents an actively investigated therapeutic strategy to bypass tumor resistance mechanisms. In this study, we describe an original approach to impact the cancer metabolism by exploiting the redox properties of a ruthenium organometallic compound. This organometallic complex...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.09.029

    authors： Vidimar V,Licona C,Cerón-Camacho R,Guerin E,Coliat P,Venkatasamy A,Ali M,Guenot D,Le Lagadec R,Jung AC,Freund JN,Pfeffer M,Mellitzer G,Sava G,Gaiddon C

    更新日期：2019-01-01 00:00:00

  • Long non-coding RNAs in glioma progression.

    abstract：:Glioma is one of most malignant primary tumors of the brain. However, due to a lack of effective means for diagnosing and treating glioma, the prognosis of glioma patients remains poor. Therefore, understanding the molecular mechanism of glioma progression is essential for effective treatment. Long non-coding RNAs (ln...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2018.01.041

    authors： Xi J,Sun Q,Ma L,Kang J

    更新日期：2018-04-10 00:00:00

  • Partial reversion of transformed phenotype of B104 cancer cells by antisense nucleic acids.

    abstract：:We used antisense RNA to inhibit the expression of oncogene neu and investigated the effects of diminished neu expression on the phenotypes of B104 cells containing activated oncogene neu. Antisense MT-neu and pSV-neo plasmids were cotransfected into neuroblastoma B104 cells. Southern analysis showed the integration o...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90028-8

    authors： Shaw YT,Chang SH,Chiou ST,Chang WC,Lai MD

    更新日期：1993-04-15 00:00:00

  • Detection of a novel lactate dehydrogenase isozyme and an apparent differentiation-associated shift in isozyme profile in hepatoma cell lines.

    abstract：:A hitherto unreported lactate dehydrogenase (LD) isoenzyme, which migrates electrophoretically to the relative position between LD2 and LD3 has been identified in the electropheratogram in 7 of 7 (100%) cultured hepatoma cell lines with various degrees of differentiation and is thus given the name LD2-3. LD2-3 seems t...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90222-4

    authors： Liu TZ,Chen PY,Chiu DT,Wei JS,Chang KS,Lin KH

    更新日期：1994-12-09 00:00:00

  • An M(r) 7-kDa membrane protein overexpressed in human multidrug-resistant ovarian cancer cells.

    abstract：:We have developed a monoclonal antibody (designated 1D7) which recognizes an M(r) 7-kDa plasma membrane protein overexpressed in ovarian MDR cancer cells. The expression of the M(r) 7-kDa protein in various human multidrug-resistant and drug-sensitive cell lines was analysed by Western blot and flow cytometry methods....

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)03634-u

    authors： Yang X,Pagé M

    更新日期：1995-01-27 00:00:00

  • Effect of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (vesnarinone) on the growth of gastric cancer cell lines.

    abstract：:Vesnarinone (OPC-8212; 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone ) is a synthetic oral cardiotonic agent that has been used for the treatment of patients with congestive heart failure. Six days of treatment with 30 microg/ml of vesnarinone induced 20-80% growth inhibitions in five out of...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00061-0

    authors： Yokozaki H,Ito R,Ono S,Hayashi K,Tahara E

    更新日期：1999-06-01 00:00:00