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Decreased cytosolic levels of the heme binding Z protein in rat hepatocyte nodules and hepatocellular carcinomas.

Abstract：

:Hepatocyte nodules and hepatocellular carcinomas were induced in male Fischer rats using the resistant hepatocyte model. The immunoreactive cytosolic levels of the heme-binding Z protein (HBP) were reduced by 56% (P less than 0.001; 2-tailed t-test) in early hepatocyte nodules (25 weeks) and hepatocellular carcinomas (10-12 months). This finding is in accordance with the previously reported reduced heme content of hepatocyte nodules and is consistent with the postulated role for HBP in intracellular heme transport and distribution. The immunoreactive levels of the glutathione S-transferase isozymes (GST) which like HBP bind heme, were elevated 2-fold (P less than 0.01) in early and late hepatocyte nodules and were unchanged in hepatocellular carcinomas.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Roomi MW,Vincent SH,Farber E,Muller-Eberhard U

doi

10.1016/0304-3835(88)90213-3

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

55-8

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(88)90213-3

journal_volume

43

pub_type

杂志文章

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