Genetic mutual relationship between PTEN and p53 in gastric cancer.

abstract：:Inadequate immunity that occurs in a tumor environment is in part due to the presence of M2-type tumor-associated macrophages (TAMs). TGF-β has a multi-functional role in tumor development including modulating the biological activity of both the tumor and TAMs. In this study, using an in vitro TAM/tumor cell co-cultur...

journal_title：Cancer letters

authors： Peng J,Tsang JY,Li D,Niu N,Ho DH,Lau KF,Lui VC,Lamb JR,Chen Y,Tam PK

更新日期：2013-05-01 00:00:00

abstract：:Retinoic acid and retinol induced functional and morphological differentiation of human promyelocytic leukemia cells (HL-60) into mature granulocytes, but did not induce functional or morphological differentiation of mouse myeloid leukemia cells (M1). Cellular retinoic acid-binding protein, but not retinol-binding pr...

journal_title：Cancer letters

authors： Takenaga K,Honma Y,Hozumi M

更新日期：1981-06-01 00:00:00

abstract：:The effect of Pseudomonas aeruginosa colonizing in the gut on the development of gastrointestinal tumors was studied in rats treated orally with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The animals were inoculated with or accidentally colonized by P. aeruginosa after MNNG treatment. In 3 serial experiments, P. aer...

journal_title：Cancer letters

authors： Morishita Y,Shimizu T

更新日期：1983-01-01 00:00:00

abstract：:The addition of recombinant human interleukin-6 (rIL-6) to either soleus or extensor digitorum longus (EDL) muscle preparations did not affect the rate of protein breakdown as measured by the rate of tyrosine released to the medium. In addition, the presence of the cytokine did not influence either the rate of protein...

journal_title：Cancer letters

authors： García-Martínez C,López-Soriano FJ,Argilés JM

更新日期：1994-01-15 00:00:00

abstract：:In situ markers for quantitative analysis of cell proliferation and apoptotic cell death have been used to evaluate both the proliferation level and net growth potential of preneoplastic nodules and malignant tumor tissues from rats experimentally induced for hepatocarcinogenesis by the dietary administration of 2-ace...

journal_title：Cancer letters

authors： Kong J,Ringer DP

更新日期：1996-08-02 00:00:00

abstract：:Mice with hereditary intestinal polyposis have mutations of the APC gene which causes formation of multiple polyps. At least one other gene influences the susceptibility for development of polyps in mice, and the locus was named Mom1. The causative gene for the Mom1 locus has recently been cloned and was found to be i...

journal_title：Cancer letters

authors： Kawamata N,Seriu T,Bartram CR,Koeffler HP

更新日期：1997-01-01 00:00:00

abstract：:The biological characteristic cell locomotion and invasion, melanin content, metalloproteinases and telomerase activity were studied in a parental mouse melanoma cell line B16 and two descendents B16BL6 and B16F10. The invasive potential of melanoma cells was assayed in a transwell cell culture chamber. Melanin conten...

journal_title：Cancer letters

authors： Zhao W,Liu H,Xu S,Entschladen F,Niggemann B,Zänker KS,Han R

更新日期：2001-01-01 00:00:00

abstract：:The lack of effective anti-tumor therapy for renal cell carcinoma (RCC) has stimulated the search for novel target whose inhibition could block tumorigenesis. Recently, reduced DLC-1 has been shown to be associated with aggressive and highly metastatic renal cell carcinoma. In this study, the biological role of DLC-1 ...

journal_title：Cancer letters

authors： Zhang T,Zheng J,Jiang N,Wang G,Shi Q,Liu C,Lu Y

更新日期：2009-09-28 00:00:00

abstract：:Circulating free DNA (CFDNA) has been shown to be a good source of liver tissue-derived DNA in African and Asian patients with chronic liver disease or HCC. In Egypt, HCC is a frequent carcinoma and mostly occur in the context of chronic infection by HCV, a widespread infection in the Egyptian population. Here we have...

journal_title：Cancer letters

authors： Hosny G,Farahat N,Tayel H,Hainaut P

更新日期：2008-06-18 00:00:00

abstract：:The binding of hematoporphyrin (HP) to human cells of the line NHIK 3025 has been studied with the aid of microfluorometry. HP is concentrated within cells when present in Hank's balanced salt solution in the concentration range 10(-5)--3 x 10(-3) M. The time course of binding is biphasic with a rapid initial binding ...

journal_title：Cancer letters

authors： Christensen T,Moan J

更新日期：1980-04-01 00:00:00

abstract：:6-(1-Hydroxyimino-4-methylpentyl)5,8-dimethyoxy 1,4-naphthoquinone S-52 (DMNQ S-52) was reported to have cytotoxic activity against L1210 leukemia cells. In the present study, we investigated the apoptotic mechanism of DMNQ S-52 in vitro and in vivo in murine solid cancer cells. DMNQ S-52 exerted cytotoxicity against ...

journal_title：Cancer letters

authors： Lee SJ,Sakurai H,Koizumi K,Song GY,Bae YS,Kim HM,Kang KS,Surh YJ,Saiki I,Kim SH

更新日期：2006-02-20 00:00:00

abstract：:RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...

journal_title：Cancer letters

authors： Landesman-Milo D,Goldsmith M,Leviatan Ben-Arye S,Witenberg B,Brown E,Leibovitch S,Azriel S,Tabak S,Morad V,Peer D

更新日期：2013-07-01 00:00:00

abstract：:The rationale for melanoma specific antitumor agents containing phenolic amines is based in part upon the ability of the enzyme tyrosinase to oxidize these prodrugs to toxic intermediates. Two phenolic amine compounds, N-acetyl-4-S-cysteaminylphenol (N-Ac-4-S-CAP) and 4-S-cysteaminylphenol (4-S-CAP), demonstrated grow...

journal_title：Cancer letters

authors： Prezioso JA,Epperly MW,Wang N,Bloomer WD

更新日期：1992-03-31 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) remain active even in the absence of cancer cells. However, the molecular mechanism underlying the sustained active status of CAFs is largely unrevealed. We found that in CAFs, DNMT3B was not only a target of miR-200b, miR-200c and miR-221, but was able to induce DNA methylation of...

journal_title：Cancer letters

authors： Tang X,Tu G,Yang G,Wang X,Kang L,Yang L,Zeng H,Wan X,Qiao Y,Cui X,Liu M,Hou Y

更新日期：2019-06-28 00:00:00

abstract：:Treatment of mouse lymphoma L5178Y cells with spermine in Fischer's medium containing bovine serum lead to formation of chromatid aberrations. The cause of this effect seems to be that bovine serum contains spermine oxidase which catalyzes oxidation of spermine to unstable aldehyde derivatives (oxidized spermine) and ...

journal_title：Cancer letters

authors： Bouzyk E,Rosiek O

更新日期：1988-02-01 00:00:00

abstract：:Immune checkpoint blockade (ICB) has revolutionised the treatment of solid tumours, yet most patients do not derive a clinical benefit. Resistance to ICB is often contingent on the tumour microenvironment (TME) and modulating aspects of this immunosuppressive milieu is a goal of combination treatment approaches. Radia...

journal_title：Cancer letters

authors： Donlon NE,Power R,Hayes C,Reynolds JV,Lysaght J

更新日期：2021-01-12 00:00:00

abstract：:Chronic myeloproliferative disorders (CMPD) are clonal disorders of the hematopoietic stem cell. The myeloid lineage shows increased proliferation with effective maturation, while peripheral leukocytosis, thrombocytosis or elevated red blood cell mass are found. In Philadelphia negative CMPD recurrent cytogenetic abno...

journal_title：Cancer letters

authors： Panani AD

更新日期：2007-09-18 00:00:00

abstract：:Interferon-beta (IFN-β) is reported to augment anti-tumor effects by temozolomide in glioblastoma via down-regulation of MGMT. Promyelocytic leukemia (PML), a gene induced by IFN-β, is a tumor suppressor. Here, we report for the first time that in combination therapy, an IFN-β-induced increase in endogenous PML contri...

journal_title：Cancer letters

authors： Okazaki T,Kageji T,Kuwayama K,Kitazato KT,Mure H,Hara K,Morigaki R,Mizobuchi Y,Matsuzaki K,Nagahiro S

更新日期：2012-10-28 00:00:00

abstract：:CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients. In the Chilean healthy group, frequencies of CYP1A1 variant alleles for MspI (m2 or CYP1A1*2A) and ile/val (val or CYP1A1*2B) polymorphisms were 0.25 and 0.33, respectively. Frequencies of variant alleles C (CYP...

journal_title：Cancer letters

authors： Quiñones L,Lucas D,Godoy J,Cáceres D,Berthou F,Varela N,Lee K,Acevedo C,Martínez L,Aguilera AM,Gil L

更新日期：2001-12-10 00:00:00

abstract：:Major cytotoxic components were fractionated from Korean mistletoe and the changes of their cytotoxic effects caused by heat treatment were investigated. The high cytotoxicity of isolated lectin I completely disappeared by heating for 30 min. The fractions of viscotoxins and alkaloids maintained their activities even ...

journal_title：Cancer letters

authors： Park JH,Hyun CK,Shin HK

更新日期：1999-05-24 00:00:00

abstract：:Brain metastasis is an important cause of morbidity and mortality in cancer-patients. Breast tumor cells frequently metastasize to brain and initiate severe therapeutic complications. In the present study, we evaluated the anti-metastatic effects of 2'-hydroxyflavanone (2HF) alone and in combination with RLIP targeted...

journal_title：Cancer letters

authors： Singhal J,Singhal P,Horne D,Salgia R,Awasthi S,Singhal SS

更新日期：2018-12-01 00:00:00

abstract：:Hepatocellular cancer (HCC) has always been considered a therapeutic challenge, given the cytoxic drug resistant nature of the cancer and associated disorder in liver function, reducing the safety of many conventional chemotherapy agents. The Multikinase inhibitor sorafenib has been found to prolong survival in patien...

journal_title：Cancer letters

authors： Kerr SH,Kerr DJ

更新日期：2009-12-01 00:00:00

abstract：:Upregulation of serine biosynthesis pathway activity is an increasingly apparent feature of many cancers. Most notably, the first rate-limiting enzyme of the pathway, phosphoglycerate dehydrogenase (PHGDH), is genomically amplified in some melanomas and breast cancers and can be transcriptionally regulated by various ...

journal_title：Cancer letters

authors： Li AM,Ye J

更新日期：2020-04-28 00:00:00

abstract：:Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade, Gli1 is also induced by non-canonical pathway...

journal_title：Cancer letters

authors： Dixit D,Ghildiyal R,Anto NP,Ghosh S,Sharma V,Sen E

更新日期：2013-08-19 00:00:00

abstract：:Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies. Hypoxia is associated with tumor progression, increased aggressiveness, enhanced metastatic potential and poor prognosis. Hypoxic tumor cells are resistant to radiotherapy and some forms of chemotherapy. Using an animal model, ...

journal_title：Cancer letters

authors： Li XF,O'Donoghue JA

更新日期：2008-06-18 00:00:00

abstract：:Multidrug-resistant MCF-7 breast adenocarcinoma cells (originally named MCF-7/AdrR cells and later re-designated NCI/ADR-RES) have served as an important and widely used research tool during the last two decades. However, the real identity of these cells has been in doubt since 1998 and has since been debated. The ori...

journal_title：Cancer letters

authors： Liscovitch M,Ravid D

更新日期：2007-01-08 00:00:00

abstract：:Internal tandem duplication (ITD) of the juxtamembrane region of FMS-like tyrosine kinase-3 (FLT3) receptor is a common type of mutation in adult acute myeloid leukemia (AML), and patient response to FLT3 inhibitors appears to be transient due to the emergence of drug resistance. We established two sorafenib-resistant...

journal_title：Cancer letters

authors： Huang A,Ju HQ,Liu K,Zhan G,Liu D,Wen S,Garcia-Manero G,Huang P,Hu Y

更新日期：2016-07-28 00:00:00

abstract：:Formation of DNA-adducts by 3-BHA or its metabolites, i.e., tert-butyl-1,4-benzoquinone (TBQ) and 5-methoxy-3-tert-butyl-1,2-benzoquinone (3-TBOQ), as well as DNA-adduct formation by 4-nitroquinoline-N-oxide (4NQO), in rat forestomach were examined by an enzymatic 32P-postlabeling assay. Four DNA-adducts were clearly ...

journal_title：Cancer letters

authors： Saito K,Nakagawa S,Yoshitake A,Miyamoto J,Hirose M,Ito N

更新日期：1989-12-01 00:00:00

abstract：:Many of the polycyclic aromatic hydrocarbons (e.g., benzo[a]pyrene (B[a]P), benzanthracene (BA), 3-methylcholanthrene (3-MC)) are not only carcinogenic, but also induce AHH in human tissues. Recently, chrysene has been implicated as an etiologic determinant of chemical carcinogenesis. Here we describe the ability of c...

journal_title：Cancer letters

authors： Snodgrass DR,McLemore TL,Marshall MV,Wray NP,Cantrell ET,Busbee DL,Arnott MA

更新日期：1979-10-01 00:00:00

abstract：:Interstitial fluid pressure was measured by the wick-in-needle technique in DMBA-induced rat mammary tumours during resting conditions and during noradrenaline infusion. The rate of infusion was chosen to increase the systemic blood pressure by 30-40 mmHg, known to result in a markedly increased vascular resistance of...

journal_title：Cancer letters

authors： Tveit E,Hultborn R,Weiss L

更新日期：1985-07-01 00:00:00