Cytotoxic effects of the components in heat-treated mistletoe (Viscum album).

abstract：:Atg4 proteases are cysteine proteases, which are well known for their crucial roles in the lipidation and delipidation of LC3 during the autophagy process. At least four human Atg4 homologs have been reported according to their sequence homology to the yeast Saccharomyces cerevisiae (Sc) Atg4. Accumulating evidence ha...

journal_title：Cancer letters

authors： Zhang L,Li J,Ouyang L,Liu B,Cheng Y

更新日期：2016-04-01 00:00:00

abstract：:The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...

journal_title：Cancer letters

authors： El-Khattouti A,Selimovic D,Haïkel Y,Megahed M,Gomez CR,Hassan M

更新日期：2014-02-01 00:00:00

abstract：:In the current study we examined the regulation of Bak, a death promoter of an apoptotic pathway, in the human breast cancer cell line MCF-7. We observed a time-dependent increase in both Bak mRNA and protein levels which appeared to correlate well with the increase in cell density. We also found that treatment of cel...

journal_title：Cancer letters

authors： Leung LK,Do L,Wang TT

更新日期：1998-02-13 00:00:00

abstract：:HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...

journal_title：Cancer letters

authors： Denizot Y,Najid A,Rigaud M

更新日期：1993-09-15 00:00:00

abstract：:Midkine (MK) is a heparin binding growth factor identified as a product of a retinoic acid-responsive gene; it is frequently expressed at high levels in many human carcinomas. Although the expression of the mRNA encoding truncated MK (tMK) in unique human cancer cells has been reported, the tMK polypeptide itself has ...

journal_title：Cancer letters

authors： Paul S,Mitsumoto T,Yamamoto I,Shinozawa T

更新日期：2001-02-26 00:00:00

abstract：:Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. ...

journal_title：Cancer letters

authors： Connolly JM,Rose DP

更新日期：1998-10-23 00:00:00

abstract：:Groups of 50 male and 50 female B6C3F1 mice inhaled 10 or 40 ppm 1,2-dibromoethane 6 h/day, 5 days/week, for 103 (10 ppm) or 90 (40 ppm) weeks. Focal epithelial hyperplasia was found in 1 (low dose group) and 10 (high dose group) males and 3 (low dose group) and 11 (high dose group) females. Squamous papillomas or ade...

journal_title：Cancer letters

authors： Stinson SF,Reznik G,Ward JM

更新日期：1981-03-01 00:00:00

abstract：:There is an urgent need to elucidate the mechanistic links between obesity and colon cancer. Convincing evidence for the role of Lgr5(+) stem cells in colon tumorigenesis has been established; however, the influence of obesity on stem cell maintenance is unknown. We assessed the effects of high fat (HF) feeding on col...

journal_title：Cancer letters

authors： DeClercq V,McMurray DN,Chapkin RS

更新日期：2015-12-28 00:00:00

abstract：:Angiogenesis is regulated by numerous "classic" factors such as vascular endothelial growth factor (VEGF) and many other endogenous "non-classic"peptides, including erythropoietin (Epo), and granulocyte-/granulocyte macrophage colony stimulating factor (G-/GM-CSF). The latter play an important regulatory role in angio...

journal_title：Cancer letters

authors： Ribatti D,Tamma R

更新日期：2019-01-01 00:00:00

abstract：:In this report we demonstrated that [3H]suramin enters polarized human colon adenocarcinoma cells when added to the apical side of the monolayer. Using light microscopic quantitative autoradiography, we showed that suramin was accumulated in the apical cytoplasm and in the nucleus. In contrast, a weak labeling was not...

journal_title：Cancer letters

authors： Baghdiguian S,Boudier JA,Boudier JL,Fantini J

更新日期：1993-12-20 00:00:00

abstract：:Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein). The deglycosylated Gc protein cannot be converted into major macrophage-activating factor (MAF), leading to immunosuppression. NaGalase is universally detected in a variety of cancer pa...

journal_title：Cancer letters

authors： Reddi AL,Sankaranarayanan K,Arulraj HS,Devaraj N,Devaraj H

更新日期：2000-09-29 00:00:00

abstract：:The 825C>T polymorphism in the gene for the G-protein beta3 subunit (GNB3) has been linked to the occurrence of a splice variant of GNB3 and distinct cellular and metabolic features and may be associated with malignant disease. 500 patients with histologically confirmed breast cancer and 500 female age-matched healthy...

journal_title：Cancer letters

authors： Krippl P,Langsenlehner U,Renner W,Yazdani-Biuki B,Wolf G,Wascher TC,Paulweber B,Samonigg H

更新日期：2004-03-31 00:00:00

abstract：:The overexpression of the MDM2 oncoprotein frequently occurs in hepatocellular carcinoma (HCC). Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type HCC, but most patients have p53-mutant tumors and intrinsic resistance to such MDM2 inhibitors. We have recently discovered that the NFAT1 tr...

journal_title：Cancer letters

authors： Wang W,Cheng JW,Qin JJ,Hu B,Li X,Nijampatnam B,Velu SE,Fan J,Yang XR,Zhang R

更新日期：2019-09-10 00:00:00

abstract：:Calcium channel blockers of 3 chemical classes and calmodulin antagonists have recently been shown to enhance the cytotoxicity of conventional cancer chemotherapeutic agents. We tested the ability of nifedipine, a dihydropyridine class calcium channel blocker, to enhance the cytotoxicity of cisplatin, the current chem...

journal_title：Cancer letters

authors： Onoda JM,Jacobs JR,Taylor JD,Sloane BF,Honn KV

更新日期：1986-02-01 00:00:00

abstract：:Modifying effects of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid (KYN-54), on intestinal carcinogenesis were examined in a rat model using azoxymethane (AOM). A total of ninety male F344 rats, 6 weeks old, were divided into 4 groups. Group 1 (20 rats) was fed a diet containing KYN-5...

journal_title：Cancer letters

authors： Mori H,Yoshimi N,Sugie S,Tanaka T,Morishita Y,Jinlong G,Tamai Y,Torihara M,Yamahara J

更新日期：1992-09-30 00:00:00

abstract：:The nuclear transcription factor kappaB (NF-kappaB) plays an important role in the development and progression of cancers. However, the mechanism by which cancer cells in the head and neck region acquire high NF-kappaB activity has not yet been clarified. In this study, we examined the NF-kappaB binding activity and t...

journal_title：Cancer letters

authors： Tamatani T,Azuma M,Aota K,Yamashita T,Bando T,Sato M

更新日期：2001-10-10 00:00:00

abstract：:Virtually all cervical cancer morbidities are associated with genital skin or mucosa cell infection with human papillomavirus (HPV). The HPV oncogenic proteins E6 and E7 are able to inactivate p53 and Rb proteins, which results in malignant transformation. Employing quantitative real-time PCR and Western blot analysis...

journal_title：Cancer letters

authors： Luczak MW,Jagodzinski PP

更新日期：2008-12-08 00:00:00

abstract：:The family of cyclin-dependent kinase complexes (Cdks) are well known for their role in the cell division cycle. What is less well known, however, is that Cdks also participate in a subset of apoptosis programs. Evidence for the role of Cdks in apoptosis comes from a variety of experimental approaches, including studi...

journal_title：Cancer letters

authors： Golsteyn RM

更新日期：2005-01-20 00:00:00

abstract：:Vascular mimicry (VM) describes the phenomenon that tumor cells but not endothelial cells form vascular-like channels, which provide blood perfusion for tumor tissues. VM is associated with tumor growth, metastasis and worse survival of different cancers. The mechanisms of VM formation remain largely unknown. We showe...

journal_title：Cancer letters

authors： Yang J,Lu Y,Lin YY,Zheng ZY,Fang JH,He S,Zhuang SM

更新日期：2016-12-01 00:00:00

abstract：:The role of mesothelial cells in the intraperitoneal spread of ovarian cancer is still elusive. In particular, it is unclear whether these cells constitute a passive barrier preventing cancer cell progression or perhaps act as an active promoter of this process. In this report we show that omental human peritoneal mes...

journal_title：Cancer letters

authors： Mikuła-Pietrasik J,Sosińska P,Kucińska M,Murias M,Maksin K,Malińska A,Ziółkowska A,Piotrowska H,Woźniak A,Książek K

更新日期：2014-12-28 00:00:00

abstract：:The potential of gadolinium neutron-capture therapy (Gd-NCT) for cancer was evaluated using chitosan nanoparticles as a novel gadolinium device. The nanoparticles, incorporating 1200 microg of natural gadolinium, were administered intratumorally twice in mice bearing subcutaneous B16F10 melanoma. The thermal neutron i...

journal_title：Cancer letters

authors： Tokumitsu H,Hiratsuka J,Sakurai Y,Kobayashi T,Ichikawa H,Fukumori Y

更新日期：2000-03-31 00:00:00

abstract：:Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, ...

journal_title：Cancer letters

authors： Sengupta A,Ghosh S,Das S

更新日期：2004-05-28 00:00:00

abstract：:Retinoic acid and retinol induced functional and morphological differentiation of human promyelocytic leukemia cells (HL-60) into mature granulocytes, but did not induce functional or morphological differentiation of mouse myeloid leukemia cells (M1). Cellular retinoic acid-binding protein, but not retinol-binding pr...

journal_title：Cancer letters

authors： Takenaga K,Honma Y,Hozumi M

更新日期：1981-06-01 00:00:00

abstract：:To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blott...

journal_title：Cancer letters

authors： Ishikawa Y,Furuta R,Miyoshi T,Satoh Y,Okumura S,Nakagawa K,Tsuchiya E

更新日期：2002-12-10 00:00:00

abstract：:The dynamic changes of chicken erythrocyte membranes induced by a series of N-methyl-N'-aryl-N-nitrosoureas (I X) were investigated in comparison with those of N-methyl-N-nitrosourea (MNU) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by electron spin resonance spectroscopy. Both I X and MNNG increased the intensity...

journal_title：Cancer letters

authors： Yano K,Sonoda M,Sakagishi Y

更新日期：1985-04-01 00:00:00

abstract：:The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the ...

journal_title：Cancer letters

authors： Heston WD,Kadmon D,Fair WR

更新日期：1982-05-01 00:00:00

abstract：:Ascorbate anion and glutathione were found to inhibit the aqueous reaction between nitrogen dioxide (NO2) and morpholine (MOR) and thereby prevented the formation of N-nitrosomorpholine (NMOR) and N-nitromorpholine (NTMOR) at both pH 7.4 and 12.5. These antioxidants are approximately 3 orders of magnitude more reactiv...

journal_title：Cancer letters

authors： Cooney RV,Ross PD,Bartolini GL

更新日期：1986-07-01 00:00:00

abstract：:We investigated the molecular mechanisms responsible for fisetin-induced apoptosis in U266 cells. Fisetin elicited the cytotoxicity in U266 cells, manifested as an increased fraction of the cells with sub-G1 content or stained positively with TUNEL labeling. Fisetin enhanced caspase-3 activation, downregulation of Bcl...

journal_title：Cancer letters

authors： Jang KY,Jeong SJ,Kim SH,Jung JH,Kim JH,Koh W,Chen CY,Kim SH

更新日期：2012-06-28 00:00:00

abstract：:The effects of turmeric (T), curcumins (Cs), aqueous turmeric extract (ATE) and curcumin-free aqueous turmeric extract (CFATE) on the formation of [3H]benzo[a]pyrene ([3H]B(a)P)-derived DNA adducts was studied in vitro employing mouse liver S9. A dose-dependent decrease in binding of [3H]B(a)P metabolites to calf thym...

journal_title：Cancer letters

authors： Deshpande SS,Maru GB

更新日期：1995-09-04 00:00:00

abstract：:The phthalocyanines are a new class of photosensitizers with promising properties for use in photodynamic therapy of cancer [E. Ben-Hur and I. Rosenthal (1985) Int. J. Radiat. Biol., 47, 145--147]. The ability of aluminum phthalocyanine tetrasulfonate (AlPCS) to cause membrane damage upon light exposure was tested usi...

journal_title：Cancer letters

authors： Ben-Hur E,Rosenthal I

更新日期：1986-03-01 00:00:00