Abstract:
:Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. This enhanced acquisition of tumor mass was a result of both increased cell proliferation and reduced apoptotic cell death and was accompanied by high angiogenic activity.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Connolly JM,Rose DPdoi
10.1016/s0304-3835(98)00171-2keywords:
subject
Has Abstractpub_date
1998-10-23 00:00:00pages
107-12issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(98)00171-2journal_volume
132pub_type
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