Effects of the synthetic trypsin inhibitor camostate on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters.

abstract：:Iron-oxide nanoparticles of small dimensions that have superparamagnetic properties show immense potential to revolutionize the future of cancer theranostics, the combinatorial diagnosis and therapeutic approach towards cancer. Superparamagnetic iron-oxide nanoparticles (SPIONs) have unique magnetic properties, due to...

journal_title：Cancer letters

authors： Santhosh PB,Ulrih NP

更新日期：2013-08-09 00:00:00

abstract：:In many parts of the world, green tea and black tea are produced from the plant Camellia sinensis. Tea is one of the most widely consumed beverages, second only to water. It is one of the safest beverages since it is made with boiling, sterile water and has been popular for over 4000 years. Dogma has it that people kn...

journal_title：Cancer letters

authors： Weisburger JH

更新日期：1997-03-19 00:00:00

abstract：:It is now increasingly evident that the immune system represents a barrier to tumor emergence, growth, and recurrence. Although this idea was originally proposed almost 50 years ago as the "immune surveillance hypothesis", it is commonly recognized that, with few rare exceptions, tumor cells always prevail. Thus, one ...

journal_title：Cancer letters

authors： Rodvold JJ,Mahadevan NR,Zanetti M

更新日期：2016-09-28 00:00:00

abstract：:In order to study the interaction between cis-diamminedichloroplatinum(II) (CDDP) and representative human DNA in a highly defined manner, alphoid sequence DNA was isolated from two human parental cancer lines (one of head and neck squamous cell origin, SCC-25, and one of breast carcinoma origin, MCF-7) as well as fro...

journal_title：Cancer letters

authors： Chan V,Elliott KE,Herman TS,Teicher BA

更新日期：1988-12-15 00:00:00

abstract：:Mice with hereditary intestinal polyposis have mutations of the APC gene which causes formation of multiple polyps. At least one other gene influences the susceptibility for development of polyps in mice, and the locus was named Mom1. The causative gene for the Mom1 locus has recently been cloned and was found to be i...

journal_title：Cancer letters

authors： Kawamata N,Seriu T,Bartram CR,Koeffler HP

更新日期：1997-01-01 00:00:00

abstract：:Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice and sunscreens, has been shown to exhibit anti-neoplastic effects in chemically induced skin and mammary cancers in several animal models. To date, no mechanism for the growth inhibitory effects of DBM on prostate cancer cells has been proposed. In ...

journal_title：Cancer letters

authors： Jackson KM,DeLeon M,Verret CR,Harris WB

更新日期：2002-04-25 00:00:00

abstract：:Increased abundance of the mRNA-binding protein human antigen R (HuR) is a characteristic feature of many cancers and frequently associated with a high grade malignancy and therapy resistance. HuR elicits a broad cell survival program mainly by stabilizing or increasing the translation of mRNAs coding for anti-apoptot...

journal_title：Cancer letters

authors： Badawi A,Hehlgans S,Pfeilschifter J,Rödel F,Eberhardt W

更新日期：2017-05-01 00:00:00

abstract：:The present study was undertaken to determine the kinetics of DNA synthesis and expression of cell cycle dependent proto-oncogenes in response to two types of cell proliferative stimuli in male Wistar rat liver. The peak of DNA synthesis was approximately 24 h after a compensatory cell proliferative stimulus induced b...

journal_title：Cancer letters

authors： Coni P,Bignone FA,Pichiri G,Ledda-Columbano GM,Columbano A,Rao PM,Rajalakshmi S,Sarma DS

更新日期：1989-09-15 00:00:00

abstract：:The traditional anti-angiogenic cancer therapy could trigger hypoxia induced factor (HIF) response, leading to "reactive resistance" to chemotherapy. Simultaneously inhibiting both angiogenesis and tumorigenesis would be ideal to overcome this limitation. MicroRNAs (miRNAs) are increasingly explored as new agents for ...

journal_title：Cancer letters

authors： Li Y,Cai B,Shen L,Dong Y,Lu Q,Sun S,Liu S,Ma S,Ma PX,Chen J

更新日期：2017-07-01 00:00:00

abstract：:Over the last decade the linkage between hyperthermia, heat shock proteins and fever with the body's immune system has been well investigated. The immunomodulatory function of hyperthermia has been found to be quite sensitively regulated by temperature, as different levels of heating can bring different modulatory eff...

journal_title：Cancer letters

authors： Zhang HG,Mehta K,Cohen P,Guha C

更新日期：2008-11-28 00:00:00

abstract：:The growth of primary subcutaneous fibrosarcomas and their pulmonary metastases was studied in normal and athymic Swiss mice. The metastases tended to develop more rapidly than did the primary tumors. However, when growth rates of tumors of small volumes (up to 1 cm3) were compared, the tumor and metastases exhibited ...

journal_title：Cancer letters

authors： Plesnicar S,Kuszynski C,Patil KD

更新日期：1982-03-01 00:00:00

abstract：:Herein we report a method for studying slow acting pharmaceutical COX-2 inhibitors in the MCF-7 breast cancer cell line where cells are grown in a three-dimensional format within an agarose matrix. The cancer cells are suspended in agarose and plated in a cell culture dish, where they will form small multicellular 'tu...

journal_title：Cancer letters

authors： Kinder DH,Aulthouse AL

更新日期：2004-03-08 00:00:00

abstract：:Ibrutinib, an inhibitor of Bruton tyrosine kinase (BTK), has shown promising pharmacologic effects in acute myeloid leukemia (AML). In this study, we report that abivertinib or AC0010, a novel BTK inhibitor, inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AM...

journal_title：Cancer letters

authors： Huang S,Pan J,Jin J,Li C,Li X,Huang J,Huang X,Yan X,Li F,Yu M,Hu C,Jin J,Xu Y,Ling Q,Ye W,Wang Y,Jin J

更新日期：2019-10-01 00:00:00

abstract：:To investigate mucin expression in breast cancer, immunohistochemical staining was performed on 30 mucinous carcinomas and 95 non-mucinous invasive carcinomas. MUC2 expression was detected in all mucinous carcinomas, but only in 11.1% of invasive ductal carcinomas, and in none of the invasive lobular carcinomas and me...

journal_title：Cancer letters

authors： Chu JS,Chang KJ

更新日期：1999-07-19 00:00:00

abstract：:Anthocyanins belong to the flavonoid family and are ubiquitous in plants, especially in flower petals and fruit peels. We established that anthocyanins isolated from fruits of Aronia melanocarpa markedly inhibited the mutagenic activity of benzo(a)pyrene and 2-amino fluorene in the Ames test. In the Sister Chromatid E...

journal_title：Cancer letters

authors： Gasiorowski K,Szyba K,Brokos B,Kołaczyńska B,Jankowiak-Włodarczyk M,Oszmiański J

更新日期：1997-10-28 00:00:00

abstract：:Oesophageal cancer is associated with high morbidity and mortality rates because it is highly invasive and prone to recurrence and metastasis, with a five-year survival rate of <20%. Therefore, there is an urgent need for new methods aimed at improving therapeutic intervention. Several studies have shown that targeted...

journal_title：Cancer letters

authors： Zhang Y,Liu S,Zhou S,Yu D,Gu J,Qin Q,Cheng Y,Sun X

更新日期：2021-01-01 00:00:00

abstract：:Succinate dehydrogenase is a heterotetrameric complex comprising four nuclear-encoded subunits, catalyzes the oxidation of succinate to fumarate in the tricarboxylic acid cycle. A subset of cancers have been found to be associated with mutations in the four SDH genes. However, the functional roles of the SDH complex i...

journal_title：Cancer letters

authors： Li J,Liang N,Long X,Zhao J,Yang J,Du X,Yang T,Yuan P,Huang X,Zhang J,He X,Xing J

更新日期：2019-10-01 00:00:00

abstract：:Lectins are suitable tools for investigating the glycoconjugate characteristics of metastatic cells. In the present study, we investigated whether there were differences between high metastatic T3 cells and a low metastatic isolate in their reactivities to several lectins specific for galactosyl and sialyl groups. Ana...

journal_title：Cancer letters

authors： Mannori G,Mugnai G,Ruggieri S

更新日期：1991-08-01 00:00:00

abstract：:As a promising method for local tumor treatment, nanosecond pulsed electric field (nsPEF) ablation elicits a potent anti-tumor immune response. However, the mechanism of the nsPEF-mediated anti-tumor immune response and its effects on the tumor microenvironment remains unclear. Here, we demonstrated that nsPEF treatme...

journal_title：Cancer letters

authors： Qian J,Chen T,Wu Q,Zhou L,Zhou W,Wu L,Wang S,Lu J,Wang W,Li D,Xie H,Su R,Guo D,Liu Z,He N,Yin S,Zheng S

更新日期：2020-12-28 00:00:00

abstract：:Numbers of circulating endothelial cells (CECs) are increased in cancer patients with progressive disease. Also, cancer patients have an increased risk for thrombotic events, being negatively associated with prognosis. Tissue factor (TF), the physiological initiator of coagulation, is present on the surface of many ex...

journal_title：Cancer letters

authors： Beerepoot LV,Mehra N,Linschoten F,Jorna AS,Lisman T,Verheul HM,Voest EE

更新日期：2004-09-30 00:00:00

abstract：:Pancreatic cancer cells are usually resistant to apoptosis mediated by tumor necrosis factor (TNF)-alpha or FasL, and their toxicity towards normal cells hampers their application for therapeutic use. TNF-related apoptosis-inducing ligand (TRAIL), a novel member of the TNF family, triggers apoptosis in a variety of ma...

journal_title：Cancer letters

authors： Ozawa F,Friess H,Kleeff J,Xu ZW,Zimmermann A,Sheikh MS,Büchler MW

更新日期：2001-02-10 00:00:00

abstract：:The phthalocyanines are a new class of photosensitizers with promising properties for use in photodynamic therapy of cancer [E. Ben-Hur and I. Rosenthal (1985) Int. J. Radiat. Biol., 47, 145--147]. The ability of aluminum phthalocyanine tetrasulfonate (AlPCS) to cause membrane damage upon light exposure was tested usi...

journal_title：Cancer letters

authors： Ben-Hur E,Rosenthal I

更新日期：1986-03-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive, deadliest, and most common brain malignancy in adults. Despite the advances made in surgical techniques, radiotherapy and chemotherapy, the median survival for GBM patients has remained at a mere 14 months. GBM poses several unique challenges to currently available treatments...

journal_title：Cancer letters

authors： Paw I,Carpenter RC,Watabe K,Debinski W,Lo HW

更新日期：2015-06-28 00:00:00

abstract：:The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription...

journal_title：Cancer letters

authors： Platet N,Hinkel I,Richert L,Murdamoothoo D,Moufok-Sadoun A,Vanier M,Lavalle P,Gaiddon C,Vautier D,Freund JN,Gross I

更新日期：2017-02-01 00:00:00

abstract：:The age-standardized mortality rates by sex for cancer of all sites and some specific sites were calculated in the 22 areas of Rosario (Argentina). The rates by area were correlated with education, occupation, housing quality and population density, applying Kendall's tau. Cervical cancer rates showed the strongest co...

journal_title：Cancer letters

authors： Poletto L,Morini JC

更新日期：1990-03-01 00:00:00

abstract：:This study was carried out to evaluate the diagnostic utility of autofluorescence photography for oral mucosal lesions. The materials consisted of 15 chemically-induced lesions containing carcinomas in 15 hamsters, and 32 oral lesions in 30 patients. In the animal models, orange fluorescence was detected in all squamo...

journal_title：Cancer letters

authors： Onizawa K,Saginoya H,Furuya Y,Yoshida H

更新日期：1996-11-12 00:00:00

abstract：:Low-frequency electromagnetic fields enhance the induction of mammary gland tumors in rats using nitrosomethyl urea. The incidence of tumors depended on the duration of exposure to static (dc) and variable (ac) magnetic fields. Variable magnetic fields induced mammary gland cancer much more frequently than static ones...

journal_title：Cancer letters

authors： Beniashvili DS,Bilanishvili VG,Menabde MZ

更新日期：1991-12-09 00:00:00

abstract：:Considerable evidences have shown that both heat shock transcription factor 1 (HSF1) and autophagy can attenuate the sensitivity of hepatocellular carcinoma (HCC) cells to chemotherapeutic reagents. However, it is still little known whether HSF1 is associated with autophagy in regulating the chemosensitivity of HCC ce...

journal_title：Cancer letters

authors： Zhang N,Wu Y,Lyu X,Li B,Yan X,Xiong H,Li X,Huang G,Zeng Y,Zhang Y,Lian J,Ni Z,He F

更新日期：2017-11-28 00:00:00

abstract：:Two hair dye components, carcinogenic 4-nitro-2-aminophenol and 5-nitro-2-aminophenol, induced Cu(II)-dependent DNA cleavage frequently at thymine and guanine residues in DNA fragments obtained from the c-Ha-ras-1 protooncogene. When the p53 tumor suppressor gene was used, 4-nitro-2-aminophenol caused Cu(II)-dependent...

journal_title：Cancer letters

authors： Chen F,Oikawa S,Hiraku Y,Murata M,Yamashita N,Kawanishi S

更新日期：1998-04-10 00:00:00

abstract：:The Wnt signaling pathway has long been known to direct growth and patterning during embryonic development. Recent evidence also implicates this pathway in the development of childhood tumors of the liver, the kidney, the brain, and the pancreas. Here, we review the current evidence on how constitutive activation of t...

journal_title：Cancer letters

authors： Koesters R,von Knebel Doeberitz M

更新日期：2003-08-20 00:00:00