Abstract：
:Mice with hereditary intestinal polyposis have mutations of the APC gene which causes formation of multiple polyps. At least one other gene influences the susceptibility for development of polyps in mice, and the locus was named Mom1. The causative gene for the Mom1 locus has recently been cloned and was found to be identical to the secretory type II phospholipase A2 (PLA2S-II) gene. Although the mechanism of contribution of PLA2S-II to formation of polyps is unclear, abnormalities of the PLA2S-II gene contribute to cellular transformation in mice. We speculated that this gene could contribute to tumorigenesis in human neoplasms. The human homologue of this gene maps to 1p35-36.1. Chromosomal deletions involving this region are frequently observed in neuroblastomas. We analyzed 19 neuroblastomas to detect point mutations of the PLA2S-II gene by PCR-single strand conformational polymorphism (SSCP). A polymorphism was detected at codon 32; no point mutations were found in the coding region of the gene. Moreover, in cases that were heterozygous at codon 32, three samples had hemizygous deletion of the gene. Taken together, PLA2S-II is frequently hemizygously deleted, but no point mutations are observed in neuroblastomas.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Kawamata N,Seriu T,Bartram CR,Koeffler HPdoi
10.1016/s0304-3835(96)04503-xsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
71-5issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(96)04503-Xjournal_volume
111pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:The T-cell lymphoma cell line YACUT was fused with the Mls-1a antigen-responsive non-tumorigenic T-cell line G4 to construct growth-arrested hybrids which could be induced to proliferate in the presence of Mls-1a antigen. Prolonged growth of the hybrids by repeated antigenic stimulation resulted in the emergence of ce...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04135-3
更新日期：1996-03-29 00:00:00
abstract：:The progression of hepatocellular carcinoma (HCC) is known to be strongly related to overexpression of hepatitis Bx (HBx) protein and dysfunction of p53. While the inhibition of p53 by HBx is well known, the effect of p53 on HBx function has not been well studied. In this report, we found that p53 affects the stabilit...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.03.019
更新日期：2009-09-18 00:00:00
abstract：:The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(82)90093-3
更新日期：1982-05-01 00:00:00
abstract：:Medroxyprogesterone acetate (MPA) is currently used therapeutically in the treatment of mammary and endometrial carcinomas. In order to develop a more potent and useful drug, we synthesized the novel compound, 9alpha-fluoromedoroxyprogesterone acetate (FMPA), by fluorinating MPA, and we also previously reported that F...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00375-x
更新日期：2000-06-01 00:00:00
abstract：:Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous history of colon cancer) and 7 were diagnosed with colon can...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(88)90023-7
更新日期：1988-01-01 00:00:00
abstract：:The induction of differentiation of SENCAR murine granulocyte-macrophage precursor cells (GM-CFU) by the tumor-promoting phorbol diester 12-O--tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by agents reported to inhibit specific aspects of arachidonic acid metabolism. These agents included phospholipase A2 inhib...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(87)90109-1
更新日期：1987-11-01 00:00:00
abstract：:MicroRNAs (miRNAs) are a group of non-coding RNAs that play a crucial role in post-transcriptional gene regulation and act as indispensable mediators in several critical biological processes, including tumorigenesis, tissue homeostasis, and regeneration. MiR-424 and miR-503 are intragenic miRNAs that are clustered on ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.08.027
更新日期：2020-12-01 00:00:00
abstract：:BRCA2-associated pancreatic ductal adenocarcinoma (PDAC) may be sensitive to agents that target homology-directed DNA repair, such as DNA crosslinking agents (DCLs) and PARP inhibitors (PARPis). Here, we assessed the sensitivities of BRCA2-deficient (Capan-1) and BRCA2-proficient (MIA PaCa-2) PDAC cell lines to a pane...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2015.04.003
更新日期：2015-08-01 00:00:00
abstract：:Sprague--Dawley rats, both intact and colostomized animals, were given 24 weekly injections of azoxymethane. Rats were fed either Rat Purina Chow or the same diet plus 0.25% disulfiram. In the intact animals, disulfiram reduced tumors from an average of 6.3 to 0.95. The number of rats developing tumors was reduced fro...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(78)80050-0
更新日期：1978-08-01 00:00:00
abstract：:The mutagenic effects of chamuvaritin, dihydrobenzylchalcone isolated from Uvaria chamae, were investigated using Salmonella typhimurium tester strains TA92, TA94--98, TA100--1535, TA1537 and TA1538. The phytochemical was mutagenic in tester strains TA98 and TA100 and required activation by the hepatic S-9 microsomal ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(79)90027-2
更新日期：1979-11-01 00:00:00
abstract：:Glioblastoma multiforme (GBM), a malignant brain tumor, is the deadliest form of human cancer with low survival rates because of its highly invasive nature. In recent years, there has been a growing appreciation for the role that glioblastoma stem cells (GSCs) play during tumorigenesis and tumor recurrence of GBM. GSC...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2018.05.007
更新日期：2018-08-10 00:00:00
abstract：:The in vitro sensitivities to differentiating agents of a murine neuroblastoma cell line (N18) and a selected variant cell line (N18-LM5) were examined. In addition, the sensitivities to differentiating agents of cells from spontaneous metastases produced by N18 cells were examined. When N18 cells (1 X 10(5) cells/mou...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90133-7
更新日期：1983-05-01 00:00:00
abstract：:Despite the improved 5-year survival rate of breast cancer, triple-negative breast cancer (TNBC) remains a challenge due to lack of effective targeted therapy and higher recurrence and metastasis than other subtypes. To identify novel druggable targets and to understand its unique biology, we tried to implement 24 pat...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.04.020
更新日期：2018-08-01 00:00:00
abstract：:Okadaic acid, a potent tumor promoter and an inhibitor of protein phosphatase 1 and 2A, has also been characterized as an angiogenic inducer in the chorioallantoic membrane of the chick embryo. To elucidate the roles of okadaic acid on angiogenic processes, we conducted in vitro angiogenesis assays. In this study, we ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.10.034
更新日期：2009-04-08 00:00:00
abstract：:Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.06.038
更新日期：2011-12-01 00:00:00
abstract：:The intrinsic limits of conventional ultrasound microbubble contrast agent greatly promoted the development and application of various nanomaterials for more efficient cancer ultrasound theranostics. Considerable successes have been achieved in the field of ultrasound molecular imaging and targeted therapy for tumor b...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2019.11.034
更新日期：2020-02-01 00:00:00
abstract：:The nuclear transcription factor kappaB (NF-kappaB) plays an important role in the development and progression of cancers. However, the mechanism by which cancer cells in the head and neck region acquire high NF-kappaB activity has not yet been clarified. In this study, we examined the NF-kappaB binding activity and t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00611-5
更新日期：2001-10-10 00:00:00
abstract：:The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated MDR, synthetic peptides cor...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.04.001
更新日期：2007-11-18 00:00:00
abstract：:Neuroblastoma is the most common extra-cranial solid tumor in children. Despite advances in the treatment of childhood cancer, outcomes for children with advanced-stage neuroblastoma remain poor. Here we reported that 2-methoxyestradiol (2-ME) inhibited the proliferation and induced apoptosis in human neuroblastoma SK...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.09.005
更新日期：2011-12-27 00:00:00
abstract：:To improve the knowledge of the underlying mechanisms of action involved in air pollution Particulate Matter (PM)-induced toxicity in human lungs, with a particular interest of the crucial role played by coated-organic chemicals, we were interested in the metabolic activation of Polycyclic Aromatic Hydrocarbons (PAH)-...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.04.044
更新日期：2008-10-18 00:00:00
abstract：:Inactivation of antineoplastics is a serious problem in cancer therapy, and prevention of the inactivation is a surpassing strategy for enhancement of their therapeutic effects. BOF-A2, which contains both EM-FU, a masked form of 5-fluorouracil (5-FU), and CNDP, an inhibitor of 5-FU degradation, was developed with thi...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00330-9
更新日期：1999-03-22 00:00:00
abstract：:In order to discover the role in the promotion process of 5-lipoxygenase (5-LO), a key enzyme in the arachidonate cascade, the antipromoting effects of the 5-LO inhibiting 3-nitro-2,4,6-trihydroxybenzamide (NTB) derivatives were studied in a two-stage transformation assay system using BALB 3T3 cells. All compounds inh...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90097-s
更新日期：1993-07-30 00:00:00
abstract：:Several classes of plant polyphenols namely, flavonoids, chalcones and coumarins exhibited varying degrees of inhibition on the cell proliferation of human colon adenocarcinoma cell line 220.1. At the highest concentration tested (100 microM), many of the chalcones showed > 100% growth inhibition and their order of po...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90147-3
更新日期：1994-07-15 00:00:00
abstract：:The mutational activation of the neu proto-oncogene was analyzed in schwannomas of the peripheral nervous system transplacentally induced by N-ethyl-N-nitrosourea (ENU) in rats. All nine primary schwannomas investigated contained a T-->A transversion mutation at nucleotide 2012 of the neu gene, leading to the substitu...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90073-i
更新日期：1993-06-15 00:00:00
abstract：:EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk. EGFR intronic SNPs rs12535536, rs207511...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.12.008
更新日期：2015-02-28 00:00:00
abstract：:Sleeping Beauty (SB) is a genetically engineered insertional mutagenesis system. Its ability to rapidly induce cancer in SB-transgenic mice as well as the ease of identification of the mutated genes suggest important roles for SB in the discovery of novel cancer genes as well as the generation of models of human cance...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2011.11.006
更新日期：2012-04-01 00:00:00
abstract：:Carcinogenic studies were performed on the skin of inbred male Lister rats using 7,12-dimethylbenz[alpha]anthracene (DMBA) in low doses (2.5 mg and 5.0 mg), followed by promotion with croton oil (CO) in one half of the animals. The clinically observed tumour rate did not differ after the two carcinogen doses and was p...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90160-w
更新日期：1992-08-14 00:00:00
abstract：:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(89)90104-3
更新日期：1989-01-01 00:00:00
abstract：:Gastric juice samples of 71 patients undergoing upper gastrointestinal endoscopy were collected as well as saliva samples from 40 of these patients. Age, sex, endoscopic diagnosis and medication were recorded. The gastric juice samples were analyzed for the presence and quantity of individual volatile N-nitrosamines, ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00467-9
更新日期：1998-02-27 00:00:00
abstract：:Glycyrrhetic acid is an anti-inflammatory agent isolated from licorice root that inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated tumor promotion in mouse skin. Although it has been established that glycyrrhetic acid inhibits a number of events induced by the phorbol ester tumor promoter TPA in cultured ce...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(90)90132-h
更新日期：1990-01-01 00:00:00
