The Wnt signaling pathway in solid childhood tumors.

abstract：:The DR5/TRAIL receptor 2 gene is a novel TNF receptor family member and induces apoptosis by overexpression of its product. DR5 is located on chromosome 8p21, where allelic deletions are often observed in advanced colorectal cancers. This evidence led us to examine whether or not mutations of the DR5 gene exist in the...

journal_title：Cancer letters

authors： Arai T,Akiyama Y,Okabe S,Saito K,Iwai T,Yuasa Y

更新日期：1998-11-27 00:00:00

abstract：:Doxycycline has been found to induce apoptosis and to inhibit the growth of a variety of tumor cells, in addition to its use as an antibiotic. However, the mechanism of its actions, especially at the molecular level, remains unknown and needs to be resolved. A crucial step possibly lies in the early period of doxycycl...

journal_title：Cancer letters

authors： Sun T,Zhao N,Ni CS,Zhao XL,Zhang WZ,Su X,Zhang DF,Gu Q,Sun BC

更新日期：2009-11-28 00:00:00

abstract：:Triple-negative breast cancer (TNBC) treatment offers only limited benefits, and it is very relevant given the significant number of deaths that it causes. DNA repair pathways can enable tumor cells to survive DNA damage that is induced by chemotherapeutic or radiation treatments. Histone deacetylase inhibitors (HDACi...

journal_title：Cancer letters

authors： Wu YH,Hong CW,Wang YC,Huang WJ,Yeh YL,Wang BJ,Wang YJ,Chiu HW

更新日期：2017-08-01 00:00:00

abstract：:The anticarcinogenic action of the garlic constituent diallyl sulfide (DAS), was examined in the hamster buccal pouch and forestomach. Groups of hamsters were topically treated, for up to 14 weeks, with a 0.5% solution of the buccal pouch and forestomach carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Prior to, duri...

journal_title：Cancer letters

authors： Nagabhushan M,Line D,Polverini PJ,Solt DB

更新日期：1992-10-21 00:00:00

abstract：:In a series of invasive ductal breast carcinoma, we investigated the status of chromosomal and intrachromosomal instability by fluorescence in situ hybridisation and determined the level of mRNA expression for two genes involved in the mitotic spindle checkpoint pathway, BUB1B and MAD2L1. All breast cancers demonstrat...

journal_title：Cancer letters

authors： Scintu M,Vitale R,Prencipe M,Gallo AP,Bonghi L,Valori VM,Maiello E,Rinaldi M,Signori E,Rabitti C,Carella M,Dallapiccola B,Altomare V,Fazio VM,Parrella P

更新日期：2007-09-08 00:00:00

abstract：:Our aim was to identify novel tumor-associated antigens from the esophageal squamous cell carcinoma (ESCC) cell line EC0156, and related autoantibodies in sera from patients with ESCC. We used modified serological proteome analysis, involving one- and two-dimensional electrophoresis, Western blot, and MALDI-TOF/TOF-MS...

journal_title：Cancer letters

authors： Gao H,Zheng Z,Mao Y,Wang W,Qiao Y,Zhou L,Liu F,He H,Zhao X

更新日期：2014-03-01 00:00:00

abstract：:In order to characterize the enzymes involved in the purine nucleotide catabolism as indicators of invasiveness and aggressiveness of malignant gliomas, the degradation of extracellular nucleotides by five different glioma cell lines was investigated and compared with primary astrocytes. Rapid hydrolysis of extracellu...

journal_title：Cancer letters

authors： Wink MR,Lenz G,Braganhol E,Tamajusuku AS,Schwartsmann G,Sarkis JJ,Battastini AM

更新日期：2003-08-20 00:00:00

abstract：:Costunolide (CT), a sesquiterpene lactone constituent isolated from Saussurea lappa (Compositae), exerted an antiangiogenic effect. CT selectively inhibited the endothelial cell proliferation induced by vascular endothelial growth factor (VEGF). Further, CT was also found to inhibit the VEGF-induced chemotaxis of huma...

journal_title：Cancer letters

authors： Jeong SJ,Itokawa T,Shibuya M,Kuwano M,Ono M,Higuchi R,Miyamoto T

更新日期：2002-12-10 00:00:00

abstract：:BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation...

journal_title：Cancer letters

authors： Fabbro M,Henderson BR

更新日期：2008-05-18 00:00:00

abstract：:The (32)P-postlabelling method for the analysis of carcinogen-DNA adducts originated 30years ago from Baylor College of Medicine in Houston and was the work of a team comprised of Kurt and Erica Randerath, Ramesh Gupta and Vijay Reddy. With subsequent modifications and developments, it has become a highly sensitive an...

journal_title：Cancer letters

authors： Phillips DH

更新日期：2013-06-28 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) is an attractive target for cancer vaccine. However, autoimmune tolerance prevents vaccines based on HER2 protein from inducing long-lasting, highly effective anti-tumor immunity. In this study, we proved that the introduction of p-nitrophenylalanine in the universal T c...

journal_title：Cancer letters

authors： Tian H,He Y,Song X,Jiang L,Luo J,Xu Y,Zhang W,Gao X,Yao W

更新日期：2018-08-28 00:00:00

abstract：:These studies examined the impact of dietary corn oil and its major constituent fatty acids on the occurrence of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary DNA adducts. In study 1, rats were fed diets containing 5, 10 or 20% corn oil for 2 weeks prior to DMBA treatment (25 mg/kg). Mammary DNA adducts increa...

journal_title：Cancer letters

authors： Schaffer EM,Milner JA

更新日期：1996-09-10 00:00:00

abstract：:The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...

journal_title：Cancer letters

authors： Papadopoulos D,Seidegard J,Rydström J

更新日期：1984-02-01 00:00:00

abstract：:Metabolic syndrome (MS) and related disorders, including cancer, are steadily increasing in most countries of the world. However, mechanisms underlying the link between MS and colon carcinogenesis have yet to be fully elucidated. In this review article we focus on the relationships between various individual associate...

journal_title：Cancer letters

authors： Ishino K,Mutoh M,Totsuka Y,Nakagama H

更新日期：2013-06-28 00:00:00

abstract：:The addition of recombinant human interleukin-6 (rIL-6) to either soleus or extensor digitorum longus (EDL) muscle preparations did not affect the rate of protein breakdown as measured by the rate of tyrosine released to the medium. In addition, the presence of the cytokine did not influence either the rate of protein...

journal_title：Cancer letters

authors： García-Martínez C,López-Soriano FJ,Argilés JM

更新日期：1994-01-15 00:00:00

abstract：:We have examined the expression of nitrotyrosine, a marker of peroxynitrite formation, in 55 esophageal cancers by immunohistochemistry. Nitrotyrosine was detected in 21 of 55 (38.2%) esophageal cancers. Comparison of nitrotyrosine expression and the pathological findings showed that there was a significant associatio...

journal_title：Cancer letters

authors： Kato H,Miyazaki T,Yoshikawa M,Nakajima M,Fukai Y,Tajima K,Masuda N,Tsutsumi S,Tsukada K,Nakajima T,Kuwano H

更新日期：2000-05-29 00:00:00

abstract：:Development of antiandrogen-resistance in advanced prostate cancer involves multiple androgen receptor (AR)-dependent and -independent pathways. Here, we demonstrated that endothelial nitric oxide synthase (eNOS) exhibited an overexpression pattern in hormone-refractory prostate cancer and several models of advanced h...

journal_title：Cancer letters

authors： Yu S,Jia L,Zhang Y,Wu D,Xu Z,Ng CF,To KK,Huang Y,Chan FL

更新日期：2013-01-01 00:00:00

abstract：:scFv fragments of a monoclonal antibody that penetrates living cells and localizes in nuclei were designed as fusion proteins with C-terminal p53 peptides and tested for restoring p53 function in p53 mutant cancer cells. scFv fragments transported a 30-mer C-terminal peptide of p53 into cancer cells and induced cellul...

journal_title：Cancer letters

authors： Weisbart RH,Miller CW,Chan G,Wakelin R,Ferreri K,Koeffler HP

更新日期：2003-06-10 00:00:00

abstract：:The induction of differentiation of SENCAR murine granulocyte-macrophage precursor cells (GM-CFU) by the tumor-promoting phorbol diester 12-O--tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by agents reported to inhibit specific aspects of arachidonic acid metabolism. These agents included phospholipase A2 inhib...

journal_title：Cancer letters

authors： Baxter CS,Lawrence AT

更新日期：1987-11-01 00:00:00

abstract：:The kinetics of total DNA adducts were compared in the liver, bladder epithelium and small intestinal epithelium of rats and mice following a single oral dose (100 mg/kg) of 3,3'-dichlorobenzidine [( 14C]DCB). Peak DNA binding (expressed as pmol DCB bound/mg DNA) in rat tissues was 153.5, 144.8 and 36.9 in the intesti...

journal_title：Cancer letters

authors： Ghosal A,Iba MM

更新日期：1990-09-01 00:00:00

abstract：:The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, a...

journal_title：Cancer letters

authors： Yi CH,Zheng T,Leaderer D,Hoffman A,Zhu Y

更新日期：2009-11-01 00:00:00

abstract：:The clinical use of chemotherapy in cancer treatment is limited by the occurrence of multidrug resistance (MDR) associated with the overexpression of membrane transporters, one of the best known is P-glycoprotein (Pgp), that actively expels drugs out of tumor cells. To overcome Pgp-mediated MDR, synthetic peptides cor...

journal_title：Cancer letters

authors： Gatouillat G,Odot J,Balasse E,Nicolau C,Tosi PF,Hickman DT,López-Deber MP,Madoulet C

更新日期：2007-11-18 00:00:00

abstract：:Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables, with particularly high levels detected in broccoli and broccoli sprouts. Over a decade ago, this phytochemical was identified as a likely chemopreventive agent based on its ability to induce Phase 2 detoxification enzymes, as well as to inhibit P...

journal_title：Cancer letters

authors： Myzak MC,Dashwood RH

更新日期：2006-02-28 00:00:00

abstract：:We subcutaneously inoculated parental and glioma cells genetically engineered to express interleukin-2 (SR/IL-2) into syngeneic mice. The tumor growth of the transfectants was slower than that of the parental cells. We then stereotactically inoculated transfectants into the brains of mice. The survival of the mice inj...

journal_title：Cancer letters

authors： Kikuchi T,Joki T,Akasaki Y,Abe T,Ohno T

更新日期：1999-01-08 00:00:00

abstract：:Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors. Many of the patients harbor insertion/deletion mutations in the hypermutable poly(C)(8) tract in exon 11 of the BHD gene. This mutational hot spot ...

journal_title：Cancer letters

authors： Jiang W,Fujii H,Matsumoto T,Ohtsuji N,Tsurumaru M,Hino O

更新日期：2007-04-08 00:00:00

abstract：:Gene amplification has been found to be biologically important in cancer. We report a complementary DNA sequence obtained using a subtractive hybridization approach which is frequently and highly amplified in human gliomas. 39/45 (87%) glial tumor specimens (of pathologically low and high grade) revealed increases in ...

journal_title：Cancer letters

authors： Liang BC,Hays L

更新日期：1996-08-02 00:00:00

abstract：:Carbaryl (1-naphthyl methyl carbamate: C12H11NO2) CAS Reg. No. 63-25-2) is a widely used broad spectrum carbamate insecticide known to exert various toxic effects on experimental animals. Along with various other toxicological effects carbaryl is reported to increase the incidence of neoplasm in various tissues in rat...

journal_title：Cancer letters

authors： Shukla Y,Antony M,Mehrotra NK

更新日期：1992-02-29 00:00:00

abstract：:Akt1 is essential for the oncogenic transformation and tumor growth in various cancers. However, the precise role of Akt1 in advanced cancers is conflicting. Using a neuroendocrine TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, we first show that the genetic ablation or pharmacological inhibition of Ak...

journal_title：Cancer letters

authors： Gao F,Alwhaibi A,Sabbineni H,Verma A,Eldahshan W,Somanath PR

更新日期：2017-08-28 00:00:00

abstract：:The newly identified protein BLAP75/RMI1 associates with the helicase BLM and is critical for the function of the homologous recombination complex. Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom's syndrome). We have analyzed the common polymorphism Ser455Asn in RMI1 an...

journal_title：Cancer letters

authors： Broberg K,Höglund M,Gustafsson C,Björk J,Ingvar C,Albin M,Olsson H

更新日期：2007-12-08 00:00:00

abstract：:The occurrence and persistence of DNA fragmentation, as detected by the alkaline elution technique, have been studied in rats treated with single oral doses of the hepatocarcinogen 2-nitropropane (2-NP). A progressive increase of liver DNA fragmentation was observed at doses ranging from 0.5 to 8 mmol/kg; single stran...

journal_title：Cancer letters

authors： Robbiano L,Mattioli F,Brambilla G

更新日期：1991-04-01 00:00:00