Abstract：
:Human epidermal growth factor receptor 2 (HER2) is an attractive target for cancer vaccine. However, autoimmune tolerance prevents vaccines based on HER2 protein from inducing long-lasting, highly effective anti-tumor immunity. In this study, we proved that the introduction of p-nitrophenylalanine in the universal T cell epitope (named NitraTh) enhances humoral immunity induced by B cell epitope and cellular immunity induced by CTL epitope. Moreover, this NitraTh epitope can work in both mouse and human immune system. When fused with extracellular domain 23-83 of HER2, NitraTh epitope help to break the self-tolerance of HER2 and induced strong HER2 specific humoral immunity and cellular immunity. Vaccination with HER2-NitraTh can significantly inhibit the growth of HER2+B16F10 tumor cells. These findings have important implications for developing therapeutic cancer vaccines.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Tian H,He Y,Song X,Jiang L,Luo J,Xu Y,Zhang W,Gao X,Yao Wdoi
10.1016/j.canlet.2018.05.021subject
Has Abstractpub_date
2018-08-28 00:00:00pages
79-87eissn
0304-3835issn
1872-7980pii
S0304-3835(18)30352-5journal_volume
430pub_type
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