Abstract：
:Currently, chemoresistance is an important cause of treatment failure in colorectal cancer. Cancer stem cells, which are a population of multi-potent cells with the capacity to self-renew and differentiate, have been found to participate in chemoresistance. In the present study, the chemotherapeutic drug oxaliplatin induced autophagy in colorectal cancer cell lines, which in turn protected cancer cells from apoptosis. Further results showed that oxaliplatin-induced autophagy enriched the population of colorectal CSCs and participated in maintaining the stemness of colorectal CSCs, thus making the cells more resistant to chemotherapy. Taken together, the results indicate that autophagy might enhance the chemoresistance of colorectal cancer cells by protecting the stemness and chemoresistance of colorectal CSCs. Our study demonstrates that autophagy plays a pro-survival role in colorectal CSCs subjected to oxaliplatin. Therefore, targeting autophagy may be considered as a potential therapeutic strategy to address chemoresistance in the treatment of colorectal cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Yang HZ,Ma Y,Zhou Y,Xu LM,Chen XJ,Ding WB,Zou HBdoi
10.1016/j.canlet.2015.02.045subject
Has Abstractpub_date
2015-05-28 00:00:00pages
128-36issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(15)00160-3journal_volume
361pub_type
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