Abstract:
:Pseudogenes are a subclass of long non-coding (lnc) RNAs that arose from protein-coding genes, but have lost the ability to produce proteins. Pseudogenes play an important role in the pathogenesis of various tumors; however, the role of pseudogenes in hepatocellular carcinoma (HCC) is poorly understood. In this study, we investigated a novel pseudogene, PDIA3P1, which was upregulated in HCC tissues compared with paired normal adjacent tissues. The expression of PDIA3P1 was significantly correlated with tumor size, metastasis, TNM stage, and overall stage. Knockdown of PDIA3P1decreased proliferation, migration, and invasion of HCC cells. PDIA3P1 knockdown also promoted cell apoptosis and inhibited tumor growth in vivo. We performed a GeneChip assay to investigate the underlying mechanism of PDIA3P1 action on biological function, and our results suggested that PDIA3P1 may promote proliferation and inhibit apoptosis of liver cancer cells by inhibiting the p53 pathway. Thus, our data suggest that PDIA3P1 acts as an oncogene in HCC and could be a potential prognostic marker and therapeutic target for HCC.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Kong Y,Zhang L,Huang Y,He T,Zhang L,Zhao X,Zhou X,Zhou D,Yan Y,Zhou J,Xie H,Zhou L,Zheng S,Wang Wdoi
10.1016/j.canlet.2017.07.031subject
Has Abstractpub_date
2017-10-28 00:00:00pages
76-83eissn
0304-3835issn
1872-7980pii
S0304-3835(17)30467-6journal_volume
407pub_type
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