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Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals.

Abstract：

:Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts and fibroblast-derived modifications of the matrix compliance contribute to the regulation of epithelial cell morphogenesis. Readjustment of matrix tension by fibroblasts can even induce a phenotypic reversion of breast carcinoma cells. These data offer a basis to develop new strategies for the normalization of the tumor stroma as an innovative target in cancer therapy.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Lühr I,Friedl A,Overath T,Tholey A,Kunze T,Hilpert F,Sebens S,Arnold N,Rösel F,Oberg HH,Maass N,Mundhenke C,Jonat W,Bauer M

doi

10.1016/j.canlet.2012.06.014

subject

Has Abstract

pub_date

2012-12-28 00:00:00

pages

175-88

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(12)00380-1

journal_volume

325

pub_type

杂志文章

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