Abstract:
:Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression levels in follicular neoplasm (P = 0.00005) and thyroiditis group (P = 0.0037) were significantly higher than that of the control group, while papillary carcinoma group did not show statistical significance. Immunohistochemistry indicated that Prx I was in epithelial cells of thyroid follicles. These results suggest that Prx I is expected to be a candidate for novel tumor markers to discriminate tissue types of tumors.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Yanagawa T,Ishikawa T,Ishii T,Tabuchi K,Iwasa S,Bannai S,Omura K,Suzuki H,Yoshida Hdoi
10.1016/s0304-3835(99)00243-8keywords:
subject
Has Abstractpub_date
1999-10-18 00:00:00pages
127-32issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(99)00243-8journal_volume
145pub_type
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