Abstract:
:High doses of folate and its quinazoline analogue with antitumour activity, N10-propargyl-5,8-dideazafolic acid (CB 3717), caused severe renal damage in mice, leading in the case of folate to death. The mouse kidneys increased in weight, which was accompanied by time- and dose-dependent induction of ornithine decarboxylase (ODC) activity. In contrast, methotrexate (MTX) had negligible effect on mouse kidneys except when applied together with the non-steroidal antiinflammatory drug, indomethacin.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Manteuffel-Cymborowska M,Chmurzyńska W,Grzelakowska-Sztabert Bdoi
10.1016/0304-3835(91)90147-asubject
Has Abstractpub_date
1991-09-01 00:00:00pages
237-41issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(91)90147-Ajournal_volume
59pub_type
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